Alzheimer's disease (AD), which is caused by the accumulation of amyloid-beta, a major medical concern today. Controlling these aggregates critical to drug development, but delivering them effectively into bloodstream poses significant challenges. In this context, aromatherapy has been proposed as an innovative and promising approach for AD disease. The volatile compounds cinnamaldehyde, phenylethyl alcohol, α-asarone, β-caryophyllene have neuroprotective effects that can be effective in...

Among therapeutic approaches for amyloid-related diseases, attention has recently turned to the use of natural products as effective anti-aggregation compounds. Although a wealth in vitro and vivo evidence indicates some common inhibitory activity these compounds, they don't generally suggest same mechanism action. Here, we show that taxifolin, ubiquitous bioactive constituent foods herbs, inhibits formation HEWL amyloid fibrils their related toxicity by causing very large globular,...

Tyrosol (TYR) and parthenolide (PLT) have been used as synthetic antioxidant natural anticancer compounds. In the current study, we aimed to synthesize an encapsulated complex of both PLT TYR in a hybrid coating layer consisting lecithin chitosan molecules, proper biocompatible drug delivery system evaluate its antibacterial potentials on human liver HepG2 pancreatic Panc cancer cell lines. The chitosan-lecithin-coated PLT/TYR nanoparticles (clPT-NPs) were synthesized applying...

The 25-35 fragment of the amyloid β (Aβ) peptide is a naturally occurring proteolytic by-product that retains pathophysiology its larger parent molecule, whose deposition has been shown to involve mitochondrial dysfunction. Hence, disruption Aβ(25-35) aggregates could afford an effective remedial strategy for Alzheimer's disease (AD). In present study, effect number selected small-molecule natural products (polyphenols: resveratrol, quercetin, biochanin A, and indoles: indole-3-acetic acid,...

Investigation of non-covalent interaction hydrophobic surfaces with the protein G (PrG) is necessary due to their frequent utilization in immunosensors and ELISA. It has been confirmed that surfaces, including carbonous-nanostructures (CNS) could orient proteins for a better activation. Herein, PrG single-walled carbon nanotube (SWCNT) graphene (Gra) nanostructures was studied by employing experimental MD simulation techniques. adequately interact both SWCNT Gra therefore fine dispersion...

Objective: This investigation aimed to increase the bioavailability and anticancer effects of allicin (AC) by encapsulating it in solid lipid nanoparticles (SLN) decorated with chitosan (CS)-conjugated folic acid (FA). Material Methods: Nanoparticles (NPs) were synthesized high-pressure homogenization, then, Fourier-transform infrared (FTIR), Field-Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DLS), zeta potential methods used determine their physicochemical...

Alzheimer's disease (AD) is a neurological disorder in which the neuronal degeneration associated with inflammatory processes and oxidative stress. Since alpha-terpineol was shown to possess antioxidant anti-inflammatory effects, administration of this compound studied on rat model AD. To create model, Aβ1-42 injected into hippocampus male Wistar rats. Generated AD models were divided simple short-term immobilization stress added. Preventive therapeutic (post-AD induction) effects...

Scientists use biological procedures as ecofriendly and cost‐effective routes to synthesis nanoparticles nanomaterials. In this work, the attitude was aimed at production of by Haplophyllum obtusifolium watery extract. Several used describe fabricated are transmission electron microscopy, ultraviolet–visible (UV–vis) spectrometry, Fourier transform infrared spectroscopy, X‐ray diffraction. UV–vis technique indicated a sharp peak in area 416 nm microscopy pictures show that shape is spherical...

Fatty liver contains a range of clinical symptoms, including the accumulation fat in parenchyma and it varies from simple steatosis to non-alcoholic steatohepatitis cirrhosis. Using natural therapies has always been great concern for such health-related diseases. Herein, 6-gingerol, as compound, was applied treat fatty induced NMRI mice. The assessment included histological studies along with measurement biochemical parameters, insulin, glucose, adiponectin, leptin, HDL-C (high-density...

Background: Infections caused by pathogenic microorganisms have increased the need for hospital care and thus represented a public health problem significant financial burden. Classical treatments consisting of traditional antibiotics face several challenges today. Anti-microbial peptides (AMPs) are conserved characteristic innate immune response among different animal species to defend against microorganisms. Objectives: In this study, new peptide sequence (mCHTL131-140) was designed using...

Effects of Terpinolene and Physical Activity on Memory Learning in a Model Alzheimer's Disease among Rats

Abstract In this study, we designed nanoparticles (NPs) based on polylactic acid glycolic modified with chitosan and folic to optimize the anti‐cancer, anti‐inflammatory, antioxidant effects of arctiin (ARC), measured its cancer cells, including colon cancer. NPs were synthesized using W1/O/W2 double‐emulsion solvent evaporation method. Physicochemical characteristics (ARC‐PCF‐NPs), average particle size, dispersity index (PDI), zeta potential (ZP), field emission scanning electron...

In this paper, we have proposed, designed, implemented, and characterized a low-cost camera-based microarray scanner which is capable of imaging fluorescently-labeled DNA or Protein microarrays. The proposed system designed to simultaneously measure two different fluorescent dyes using parallel channels increase the overall scan speed. We shown that wide dynamic range makes it able detect fluorophore densities from 100-10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Abstract Alzheimer's disease (AD) is a multifactorial in which environmental factors play role. Among factors, air pollution vital issue modern life. Despite extensive considerations, it remains uncertain how mediates neurodegeneration AD. Beta‐amyloids and hyperphosphorylated tau proteins are the two main pathological markers that have been studied AD so far. Tau protein basically phosphoprotein whose functions controlled by phosphorylation. The function of to be located on surface...