Isabel Neale
A5012828302- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- COVID-19 epidemiological studies
- Food composition and properties
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Vaccine Coverage and Hesitancy
- Enzyme Production and Characterization
- Long-Term Effects of COVID-19
- Biofuel production and bioconversion
University of Oxford
2022-2024
Medawar Building for Pathogen Research
2022-2024
Mahidol Oxford Tropical Medicine Research Unit
2023-2024
Mahidol University
2023-2024
ETH Zurich
2020
École Polytechnique Fédérale de Lausanne
2020
Abstract Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many individuals possessing hybrid immunity, generated through a combination of vaccination and infection. Concerns have been raised that omicron breakthrough infections triple-vaccinated result poor induction omicron-specific prior infection is associated with dampening. Taking broad comprehensive approach, we characterize mucosal blood immunity to spike non-spike antigens following BA.1/BA.2 triple...
What determines the number of starch granules in plastids is an enigmatic aspect metabolism. Several structurally and functionally diverse proteins have been implicated granule initiation process Arabidopsis (Arabidopsis thaliana), with each protein exerting a varying degree influence. Here, we show that conserved synthase-like protein, STARCH SYNTHASE5 (SS5), regulates form chloroplasts. Among synthases, SS5 most closely related to SS4, major determinant morphology. However, unlike SS4...
Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs policy for booster doses and future designs. Existing studies demonstrate humoral protection, but the role T cells in is still unclear. In this study, we explore antibody cell immune responses associated with Delta variant a well-characterized cohort UK Healthcare Workers (HCWs). We evidence to support CD4+ CD8+ as well antibodies infection. addition,...
Abstract Objective: Obesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral cellular immune responses SARS-CoV-2 in adult COVID-19 survivors with overweight/obesity (Ov/Ob, BMI ≥ 23 kg/m2) DM Bangladesh. Methods: In this cross-sectional study, SARS-CoV-2-specific antibody T-cell were investigated 63 healthy 75 PCR-confirmed recovered...
ABSTRACT T cell correlates of protection against SARS-CoV-2 infection after vaccination (‘vaccine breakthrough’) are incompletely defined, especially the specific contributions CD4+ and CD8+ cells. We studied 279 volunteers in Protective Immunity from Cells Healthcare Workers (PITCH) UK study, including 32 cases (with positive testing two vaccine doses during Delta-dominant era) 247 controls (no test nor anti-nucleocapsid seroconversion this period). 28 days second vaccination, before all...
Abstract Both infection and vaccination, alone or in combination, generate antibody T cell responses against SARS-CoV-2. However, the maintenance of such – hence protection from disease requires careful characterisation. In a large prospective study UK healthcare workers (Protective immunity cells Healthcare (PITCH), within larger SARS-CoV-2 & reinfection evaluation (SIREN) study) we previously observed that prior impacted strongly on subsequent cellular humoral induced after long short...
Abstract Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in large numbers of individuals with hybrid immunity, generated through a combination vaccination and infection. Based primarily on circulating neutralizing antibody (NAb) data, concerns have been raised that omicron breakthrough infections triple-vaccinated result poor induction omicron-specific history prior particular is associated profound dampening. Taking broader comprehensive approach, we characterized...
Abstract Objective Obesity and type 2 diabetes (DM) are risk factors for severe COVID-19 outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral cellular immune responses SARS-CoV-2 in adult survivors with obesity DM Bangladesh. Methods In this cross-sectional study, SARS-CoV-2-specific antibody T cell were investigated 63 healthy 75 PCR-confirmed recovered individuals Bangladesh, during pre-vaccination first wave of pandemic 2020....