Sven Kerneis
A5009834437- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Diabetes Management and Research
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- Pharmacovigilance and Adverse Drug Reactions
- Autoimmune Bullous Skin Diseases
- Drug-Induced Adverse Reactions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- vaccines and immunoinformatics approaches
- Diabetes Management and Education
Lewisham and Greenwich NHS Trust
2024
Oxford University Hospitals NHS Trust
2021-2022
University of Oxford
2020-2022
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody measurements can be used to estimate the proportion of a population exposed or infected and may informative about risk future infection. Previous estimates duration responses vary. Methods We present 6 months data from longitudinal seroprevalence study 3276 UK healthcare workers (HCWs). Serial SARS-CoV-2 anti-nucleocapsid anti-spike IgG were obtained. Interval censored survival...
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
The overdiagnosis of penicillin allergy and misclassification non-truly allergic reactions is a growing public health problem, associated with the overuse broad-spectrum restricted antimicrobials. We aimed to evaluate impact status on antimicrobial prescribing. A retrospective study inpatients documented receiving antimicrobials was conducted from 1st April July 2021. Antimicrobial prescribing clinical characteristics were compared between patients an active label those whose removed...