A5002206022- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Food Security and Health in Diverse Populations
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Sex work and related issues
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- Hepatitis C virus research
- Stress Responses and Cortisol
- Rheumatoid Arthritis Research and Therapies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chemical Reactions and Mechanisms
- Poxvirus research and outbreaks
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS oral health manifestations
- LGBTQ Health, Identity, and Policy
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
University of Mississippi Medical Center
2007-2025
University of Alabama at Birmingham
2024
Jackson Memorial Hospital
2021-2024
University of Glasgow
2021-2024
Wrexham Maelor Hospital
2024
NHS Greater Glasgow and Clyde
2019-2021
Millsaps College
2006
State Street (United States)
2006
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 2,204 (12%) failed to develop anti-spike antibodies, an additional 600 (27%) generating low levels (<380 AU ml −1 ). Vaccine failure rates highest ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis...
Abstract We report 12 patients with persistent viremia on oral antiretroviral therapy who were initiated injectable cabotegravir/rilpivirine (iCAB/RPV) without lead-in. All achieved viral suppression any virologic rebound. iCAB/RPV may be considered as an option for unable to maintain therapy.
BackgroundThe humoral and T-cell responses to booster COVID-19 vaccine types in multidisease immunocompromised individuals who do not generate adequate antibody two doses, is fully understood. The OCTAVE DUO trial aimed determine the value of third vaccinations a wide range patients with primary secondary immunodeficiencies.MethodsOCTAVE-DUO was prospective, open-label, multicentre, randomised, controlled, phase 3 investigating are following dose BNT162b2 or mRNA-1273, NVX-CoV2373 for those...
Characterizing the genetically diverse HIV sequences that persist in reservoir despite antiretroviral therapy (ART) is critical to cure efforts. Our observations confirm proviruses persisting blood on ART, which are largely defective, broadly reflect extent of within-host evolution pre-ART. Moreover, on-ART clonal expansion not appreciably accompanied by loss distinct proviral lineages. In fact, genetic composition remained stable all but one participant, whom, after 12 years dating around...
Pre-exposure prophylaxis (PrEP) is highly efficacious for preventing HIV but has not yet been brought to scale among at-risk persons. In several clinical trials in urban areas, technology-based interventions have shown a positive impact on PrEP adherence. rural and small-town areas the United States, which often do geographically proximal access providers, additional support may be needed. This particularly true younger persons who are more likely face multiple barriers accessing services....
Abstract Background Long-acting antiretroviral regimens have the potential to achieve virologic suppression in people unable maintain adherence daily oral therapy (ART). injectable cabotegravir/rilpivirine (LAI CAB/RPV) is currently only complete long-acting regimen and recommended by IAS-USA for select patients with viremia. However, resistance-associated mutations (RAMs) among treatment-experienced HIV are common, precluding use of LAI CAB/RPV. CAB/RPV plus subcutaneous lenacapavir (LEN)...
Little is known about serological responses to MVA-BN (JYNNEOS) against mpox in elderly individuals with or without HIV. In this study, induced sustained IgG levels regardless of HIV status even up one year. Birth before 1973 correlated higher IgG. unvaccinated had lower than vaccinated.
The prevalence of diabetes mellitus and its associated complications, particularly diabetic foot pathologies, poses significant healthcare challenges economic burdens globally. This review synthesises current evidence on the surgical management foot, focusing interplay between neuropathy, ischemia, infection that commonly culminates in ulcers, infections, and, severe cases, amputations. escalating incidence underscores urgency for effective strategies, as complications are a leading cause...
Suboptimal HIV pre-exposure prophylaxis (PrEP) care outcomes among Black/African American men who have sex with (MSM) limits its population-level effects on incidence. We conducted a pilot study of brief patient navigation intervention aimed at improving PrEP initiation and persistence MSM in the Southern United States. Community health center Jackson, MS. recruited 60 aged 18-34 years were newly prescribed PrEP. Participants randomized to receive clinic's current standard or an condition...
Abstract Background Integrase strand transfer inhibitors (INSTIs) and the menopausal transition have been associated with body composition changes in women human immunodeficiency virus (WWH), but their interaction is unknown. Methods From 2006 to 2019, 1131 virally-suppressed WWH (419 who switched INSTI [INSTI+]; 712 did not switch [INSTI–]) 887 without HIV (WWOH) from Women's Interagency Study were included. Mixed-effects models used evaluate change waist circumference (WC) mass index (BMI)...
Abstract Background HIV disproportionately affects men who have sex with (MSM) in the USA, and new infections continue to increase, particularly among African American (AA) Hispanic/Latino (H/L) MSM. Rates of testing are low AA H/L MSM, innovative approaches encourage may help address high incidence these men. self-testing (HST) be an important tool for increasing rates frequency testing. HST well-suited given that stigma mistrust medical care contribute rates. Despite its promise, however,...
Abstract Background Rapid antiretroviral therapy (ART), ideally initiated within twenty-four hours of diagnosis, may be crucial in efforts to increase virologic suppression and reduce HIV transmission. Recent studies, including demonstration projects large metropolitan areas such as Atlanta, Georgia; New Orleans, Louisiana; San Francisco, California; Washington D.C., have demonstrated that rapid ART initiation is a novel tool for expediting viral clinical settings. Here we present an...
To describe the demographics, clinical characteristics, and outcomes of hospitalized adults with coronavirus disease 2019 (COVID-19) in an academic medical center southern United States.Retrospective, observational cohort study all adult patients (18 years older) consecutively admitted laboratory-confirmed severe acute respiratory syndrome-coronavirus-2 infection between March 13 April 25, 2020 at University Mississippi Medical Center. All either survived to hospital discharge or died during...
Despite the prevalence of human immunodeficiency virus (HIV) in Mississippi, access to pre-exposure prophylaxis (PrEP) is mostly limited urban areas. Remote PrEP care via telemedicine, HIV self-testing, and prescription mail delivery can improve underserved communities. This mixed methods study assessed acceptability feasibility using remote care, compared alternatives. consisted (1) a cross-sectional survey (2) interviews. PrEP-eligible adults were recruited from community-based...
Pre-exposure prophylaxis (PrEP) uptake remains low in the southeastern United States (“the South”), likely owing to overlapping structural barriers, including lack of nearby PrEP providers. Federally qualified health centers (FQHCs) are potential sites through which expand availability South, and telemedicine is promising for these services. This study investigated considerations implementation at FQHCs use qualitative interviews with 19 FQHC staff 17 PrEP-eligible patients Mississippi....
Abstract Few instances of treatment-emergent resistance to bictegravir have been reported in the literature. We describe a case person recently diagnosed with human immunodeficiency virus who developed M184V and R263K mutations while on therapy.
The coronavirus disease 2019 (COVID-19) pandemic continues to put strain on health systems in the United States, leading significant shifts delivery of routine clinical services, including those offering HIV pre-exposure prophylaxis (PrEP). We aimed assess whether individuals discontinued PrEP use at higher rates during COVID-19 and extent which disruptions usual care were mitigated through telehealth. Using data from an ongoing prospective cohort men who have sex with (MSM) newly initiating...
Abstract Background Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, contemporary trends are not well described. Methods The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40–75 years, receiving ART, had low-to-moderate cardiovascular disease risk. ART was summarized within Global Burden Disease (GBD) super-regions, adjusted linear logistic regression analyses...
Abstract Background The M184V/I mutation is a common in treatment-experienced patients with HIV and confers high-level resistance to lamivudine emtricitabine. Our objective assess the effectiveness of bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) real-world setting achieving maintaining viral suppression documented mutations. Methods This case series comprised HIV-positive historical or newly-identified mutations who were placed on BIC/FTC/TAF as switch strategy therapy...
<h3>Background:</h3> Multiple mechanisms underly the major burden of rheumatoid arthritis (RA) pain. The high prevalence co-existing fibromyalgia (FM) supports contribution central nervous system associated nociplastic pain pathways. In RA, we previously employed functional MRI (fMRI) brain to objectively demonstrate (hyperconnectivity between Default Mode Network [DMN] and Insula). addition, among those with FM, observed a significant relationship peripheral inflammation hyperconnectivity,...