A5074390442- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Photonic and Optical Devices
- Sports Performance and Training
- Semiconductor Lasers and Optical Devices
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extraction and Separation Processes
- Muscle activation and electromyography studies
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Spaceflight effects on biology
- Landslides and related hazards
- Analytical chemistry methods development
- Non-Invasive Vital Sign Monitoring
- Chemical Synthesis and Characterization
- Radioactive element chemistry and processing
- Photonic Crystals and Applications
- Optical Network Technologies
- Advanced Photonic Communication Systems
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Semiconductor Quantum Structures and Devices
- Sports injuries and prevention
Nagoya University
2016-2025
Public Works Research Institute
2012-2023
Hokkaido University
1967-2021
Daido University
2021
Waseda University
2007-2019
National Institute of Advanced Industrial Science and Technology
2019
University of Tsukuba
2019
Ono Pharmaceutical (Japan)
2000-2017
Ohio University
2015-2016
Nara Prefecture General Medical Center
2016
Tibetan natives have lived on the plateau (altitude ∼4,000 m) for at least 25,000 years, and as such they are adapted to life reproduction in a hypoxic environment. Recent studies identified two genetic loci, EGLN1 EPAS1, that undergone natural selection Tibetans, further demonstrated an association of EGLN1/ EPAS1 genotype with hemoglobin concentration. Both genes encode major components hypoxia-inducible factor (HIF) transcriptional pathway, which coordinates organism's response hypoxia....
The purpose of the present study was to elucidate influence intermittent hypobaric hypoxia at rest on endurance performance and cardiorespiratory hematological adaptations in trained athletes. Twelve male runners were assigned either a hypoxic group (n = 6) or control 6). subjects exposed simulated altitude 4500 m for 90 min, three times week 3 weeks. measurements 3000 running time, time exhaustion, parameters during maximal exercise test resting status performed before (Pre) after weeks...
InGaAsP/InP optical switches have been fabricated which use a carrier induced refractive index change. Switching has achieved with power isolation of 20.5 dB in 1-mm-long device multimode operation. This is promising new step toward making integrated circuits.
The purpose of this study was 1) to test the hypothesis that ventilation and arterial oxygen saturation (Sa O 2 ) during acute hypoxia may increase intermittent remain elevated for a week without hypoxic exposure 2) clarify whether changes in Sa exercise are correlated with change chemosensitivity. Six subjects were exposed simulated altitude 4,500 m 7 days (1 h/day). Oxygen uptake (V˙o ), expired minute (V˙e), measured maximal submaximal at 432 Torr before (Pre), after (Post), again sea...
The purpose of this study was to elucidate the influence inspiratory muscle fatigue on sympathetic nerve activity (MSNA) and blood pressure (BP) response during submaximal exercise. We hypothesized that would elicit increases in vasoconstrictor outflow BP dynamic leg subjects carried out four exercise tests: two were maximal (PI(max)) tests MSNA tests. In PI(max) tests, performed 10-min exercises at 40% peak oxygen uptake using a cycle ergometer semirecumbent position [spontaneous breathing...
Acute exercise has been demonstrated to improve cognitive function. In contrast, severe hypoxia can impair Hence, function during under may be determined by the balance between beneficial effects of and detrimental hypoxia. However, physiological factors that determine remain unclear. Here, we examined combined acute on identified The participants completed tasks at rest moderate either normoxic or hypoxic conditions. Peripheral oxygen saturation, cerebral oxygenation, middle artery velocity...
Previous studies have shown that acute exercise elevates sex steroid hormone concentrations in rodents and sprint increases circulating testosterone healthy young men. However, the effect of different intensities on responses at levels physical fitness is still unclear. In this study, we compared athletes non-athletes. Eight male endurance 11 non-athletes performed two 15 min sessions submaximal 40 70% peak oxygen uptake (V̇(O2peak)), respectively, exercised 90% V̇(O2peak) until exhaustion....
Eliminating risk factors for falls leads to reduction of the incidence frailty. The recommended training program used only body weight resistance and no equipment prepare quick movements in daily living community-dwelling older adults is unknown. Thus, we compared effects weight-bearing with (WEM) without explosive motions (WOEM). Sixty were randomly assigned WEM WOEM groups. group performed concentric phase during repetitions quickly it at traditional velocity. designated programs consisted...
In the system ZrO 2 –Al O 3 , a new method for preparing solid solutions from ZrCl 4 and AlCl using hydrazine monohydrate is investigated. c ‐ZrO containing up to ∼40 mol% Al crystallize at low temperatures amorphous materials. The formation mechanism discussed IR spectral data. values of lattice parameter α increase linearly 0.5072 0.5105 nm with increasing content. At higher temperatures, transformation proceeds as follows: ( SS ) → t ss +α‐Al m . –α‐Al composite ceramics are fabricated by...
The two-component systems (TCS), or histidine-to-aspartate phosphorelays, are evolutionarily conserved common signal transduction mechanisms that implicated in a wide variety of cellular responses to environmental stimuli both prokaryotes and eukaryotes including plants. Among higher plants, legumes Lotus japonicus have unique ability engage beneficial symbiosis with nitrogen-fixing bacteria. We previously presented genome-wide compiled list TCS-associated components Mesorhizobium loti,...
Purpose: It is reported that the rate of locomotor muscle fatigue development during intermittent isometric exercise in hypoxia accelerated compared with normoxia. In contrast, when sustained contractions are used, some studies do not show any effect on development. Increased intramuscular pressure causes substantial and ischemia, even Therefore, we hypothesized difference deoxygenation between normoxia would be small this may contribute to inconsistent findings. Methods: Subjects performed...
It was demonstrated that acute hypoxia increased muscle sympathetic nerve activity (MSNA) by using a microneurographic method at rest, but its effects on dynamic leg exercise are unclear. The purpose of this study to clarify changes in MSNA during hypoxia. To estimate peak oxygen uptake (Vo(2 peak)), two maximal tests were conducted cycle ergometer semirecumbent position normoxia [inspired fraction (Fi(O(2)) = 0.209] and 0.127). subjects performed four submaximal tests; trials hypoxia,...
New Findings What is the central question of this study? Premenopausal women have an attenuated inspiratory muscle metaboreflex‐induced increase in arterial blood pressure compared with men. It unclear whether sympathetic vasomotor outflow during dynamic exercise increased activation less young than main finding and its importance? The magnitude leg cycling resistance was smaller Less metaboreflex could be one mechanisms for muscle‐induced women. Abstract We changes nerve activity (MSNA)...
The present study was performed to clarify the effects of intermittent exposure an altitude 4,500 m with endurance training and detraining on ventilatory chemosensitivity. Seven subjects (sea-level group) trained at sea level 70% maximal oxygen uptake (VO2 max) for 30 min/day, 5 days/wk 2 wk, whereas other seven (altitude same relative intensity (70% VO2 in a hypobaric chamber. max, hypoxic response (HVR), hypercapnic response, as index central chemosensitivity (HCVR) peripheral (HCVRSB),...
To determine the adaptive changes in several molecules regulating muscle hypertrophy and atrophy after unloading, we examined whether unilateral lower limb suspension mRNA protein levels of SRF-linked (RhoA, RhoGDI, STARS SRF), myostatin-linked (myostatin, Smad2, Smad3 FLRG) Foxo-linked (P-Akt, Foxo1, Foxo3a Atrogin-1) mediators.A single each eight healthy men was suspended for 20 days. Biopsy specimens were obtained from vastus lateralis pre- post-suspension.The volume significantly...