A5027545625- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Cancer Immunotherapy and Biomarkers
- Animal Genetics and Reproduction
- Gastric Cancer Management and Outcomes
- Plant Molecular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Chemotherapy-related skin toxicity
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Zebrafish Biomedical Research Applications
- Nausea and vomiting management
- Electrolyte and hormonal disorders
- Chemotherapy-induced organ toxicity mitigation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
Mie University Hospital
2015-2024
Kumamoto University
2022
St. Marianna University School of Medicine
2022
Mie University
2008-2022
National Cancer Center Hospital East
2006-2022
Nagoya City University
2019-2022
Aichi Cancer Center
2016-2022
University of Tokyo Hospital
2022
University hospital Medical Information Network
2022
Japanese Society of Medical Oncology
2022
Adjuvant trastuzumab monotherapy has not been compared with + chemotherapy. We investigated the relative value of for older patients breast cancer.This study was an open-label, randomized controlled a treatment selection design in which noninferiority criterion predefined. Patients aged 70-80 years surgically treated human epidermal growth factor receptor 2-positive invasive cancer received or The primary end point disease-free survival (DFS) assessment prespecified hazard ratio (HR),...
His to Asp phosphorelay signal transduction mechanisms involve three types of widespread signaling components: a sensor His-kinase, response regulator, and histidine-containing phosphotransfer (HPt) domain. In Arabidopsis, several His-kinases have recently been discovered (e.g., ETR1 CKI1) through extensive genetic studies. Furthermore, recent search for regulators in this higher plant revealed that it possesses group (ARR-series), each which exhibits the phospho-accepting receiver function....
The formation of Spemann organizer is one the most important steps in dorsoventral axis determination vertebrate development. However, whether forms autonomously or induced non-cell-autonomously controversial. In this report we have isolated a novel zebrafish homeobox gene, dharma, capable inducing ectopically. expression dharma was first detected several blastomeres at side margin soon after mid-blastula transition and continued dorsal yolk syncytial layer (YSL) under embryonic shield,...
Abstract Purpose We present the English version of The Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for systemic treatment breast cancer, 2018 edition. Methods JBCS formed a task force to update Guidelines, 2015 edition, according Minds Handbook Guideline Development 2014. First, we set multiple outcomes each clinical question (CQ). Next, quantitative or qualitative systematic review was conducted outcomes, and strength recommendation CQ taken into consideration during...
In Arabidopsis thaliana, a number of response regulators are presumably involved in His-Asp phosphorelay signal transduction to environmental stimuli, such as phytohormones. Previously, it was shown that expression certain set genes for cytokinin- and nitrate-responsive their mRNA accumulation, under growth conditions [Taniguchi et al. (1998) FEBS Lett. 429: 259, Brandstatter Kieber Plant Cell 10: 1009]. To answer the critical question whether or not other regulator genes, so far identified...
ABSTRACT Analyses using amphibian embryos proposed that induction and anteroposterior patterning of the central nervous system is initiated by signals are produced organizer organizer-derived axial mesoderm. However, we show here initial pattern zebrafish depends on differential competence epiblast not imposed signals. This information present throughout in ectodermal cells normally give rise both to neural non-neural derivatives. Because this information, tissues transplanted ventral side...
In Arabidopsis thaliana, it is currently believed that the members of a small family PSEUDO-RESPONSE REGULATOR (PRR) proteins, including TOC1 (TIMING OF CAB EXPRESSION 1), coordinately play roles close to circadian clock. Among these PRR members, PRR9 gene unique in not only does its transcription oscillate diurnally, but also rapidly induced by light manner dependent on phytochromes. These events at level must be crucial for clock-associated functions PRR9. Nonetheless, little known about...
The two-component systems (TCS), or histidine-to-aspartate phosphorelays, are evolutionarily conserved common signal transduction mechanisms that implicated in a wide variety of cellular responses to environmental stimuli both prokaryotes and eukaryotes including plants. Among higher plants, legumes Lotus japonicus have unique ability engage beneficial symbiosis with nitrogen-fixing bacteria. We previously presented genome-wide compiled list TCS-associated components Mesorhizobium loti,...
The pseudo-response regulators (PRRs) are the circadian clock component proteins in model dicot Arabidopsis thaliana. They contain a receiver-like domain (RLD) similar to receiver domains of RRs His–Asp phosphorelay system, but RLDs lack phosphoacceptor aspartic acid residue invariably conserved domains. To study evolution PRR genes plants, here we characterize their homologue genes, PpPRR1, PpPRR2, PpPRR3 and PpPRR4, from moss Physcomitrella patens. In phylogenetic analysis, PpPRRs cluster...
This trial is conducted to investigate the benefit of trastuzumab monotherapy compared with a combination therapy and chemotherapy in women over 70 years human epidermal growth factor receptor type-2-positive primary breast cancer. Inclusion criteria are following: histologically diagnosed as invasive cancer received curative operation for cancer; Stage I, IIA, IIB or IIIA/M0; baseline left ventricular ejection fraction ≥55%. Patients randomized receive either (8 mg/kg loading dose, 6 every...
Cholesteryl pullulan (CHP) is a novel antigen delivery system. CHP and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) complexes (CHP-NY-ESO-1) present multiple epitope peptides to the MHC class I II pathways. Adjuvants are essential for cancer vaccines. MIS416 non-toxic microparticle that activates immunity via nucleotide-binding oligomerization domain 2 (NOD2) TLR9 However, no reports have explored as vaccine adjuvant. We conducted first-in-human clinical trial of CHP-NY-ESO-1...
Cytokine release syndrome (CRS) is a potentially life-threatening systemic disease that has been observed after treatment with antibodies and adoptive T cell therapies. In this case, we nivolumab-induced CRS in patient gastric cancer.A 43-year-old male advanced cancer was treated nivolumab as third-line chemotherapy. He had no history of allergies. Eight days the first administration nivolumab, fever, tachycardia, appetite loss increases liver biliary enzymes were observed. Computed...
We report findings on quality of life (QoL) in the RESPECT trial, which compared adjuvant trastuzumab monotherapy with plus chemotherapy older patients human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC).Patients age 70-80 years 2-positive surgically treated were randomly assigned to receive (T) or (T + C). QoL was assessed using Functional Assessment Cancer Therapy-General (FACT-G), Philadelphia Geriatric Center Morale Scale, Hospital Anxiety and Depression Patient...
510 Background: The relative value of trastuzumab (H) monotherapy as an adjuvant treatment compared to the standard combination with chemotherapy (CT) is not clear for elderly breast cancer (BC) patients (pts). Methods: We randomly assigned pts over 70 years (yrs) old HER2-positive invasive BC who received curative surgery into either H (H group) or plus CT (H+CT selected from pre-specified regimens (PTX/DTX/TC/AC/EC/FEC/CMF/TCb [CBDCA]). primary endpoint was disease-free survival (DFS), and...
Gangliosides (acidic glycosphingolipids) have crucial regulatory roles in normal physiological processes, as well pathological conditions, including tumor onset and progression. GD2 is highly expressed triple-negative breast cancer (TNBC), particularly stem cells. However, little known on the clinical impact of expression prognosis TNBC. Consequently, we aimed to investigate association between TNBC TNBC.We assessed 76 patients with primary who had undergone surgery at our Institute 2012...
Many patients with malignant diseases are frequently complicated some type of thrombosis, such as venous thromboembolism (VTE) or disseminated intravascular coagulation (DIC).This retrospective study was designed to examine the frequency thrombosis in 478 comparison that observed 121 without and evaluate efficacy fibrin-related markers (FRMs), soluble fibrin, fibrinogen fibrin degradation products D-dimer, diagnosing thrombosis.The including 62 cases VTE, 63 DIC nine cerebrovascular...
Abstract Background The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to standard has not been evaluated. Methods Patients were randomly assigned the control arm or response-guided (Ki-67 arm). Primary biopsies obtained before treatment, and three once-weekly doses paclitaxel trastuzumab assess interim index. In arm, continued for total 12 doses, regardless subsequent treatment was early responder is...