A5030408391- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Pneumothorax, Barotrauma, Emphysema
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trauma Management and Diagnosis
- Amoebic Infections and Treatments
- Medical Imaging and Pathology Studies
- Radiology practices and education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Hearing Loss and Rehabilitation
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Genetic and phenotypic traits in livestock
- Obstructive Sleep Apnea Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Lymphatic Disorders and Treatments
- Palliative Care and End-of-Life Issues
- Transplantation: Methods and Outcomes
Oxford University Hospitals NHS Trust
2015-2024
University of Oxford
2012-2023
Churchill Hospital
2011-2023
Government of the United Kingdom
2023
John Radcliffe Hospital
2014-2022
Oxford Centre for Diabetes, Endocrinology and Metabolism
2009-2019
Oxford BioMedica (United Kingdom)
2009-2016
Oxford Biomedical Research
2010-2016
National Institute for Health Research
2010-2015
University of Liverpool
2010
More than 30% of patients with pleural infection either die or require surgery. Drainage infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial.We conducted a blinded, 2-by-2 factorial trial which 210 were randomly assigned receive one four study treatments for 3 days: double placebo, tissue plasminogen activator (t-PA) and DNase, t-PA DNase placebo. The primary outcome was the change opacity,...
<h3>Context</h3>Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined.<h3>Objective</h3>To determine whether indwelling catheters (IPCs) are more than chest tube and talc slurry pleurodesis (talc) at relieving dyspnea.<h3>Design</h3>Unblinded randomized controlled trial (Second Therapeutic Intervention Malignant Effusion Trial [TIME2]) comparing...
INTRODUCTION The Modified Early Warning Score (MEWS) is a simple, physiological score that may allow improvement in the quality and safety of management provided to surgical ward patients. primary purpose prevent delay intervention or transfer critically ill PATIENTS AND METHODS A total 334 consecutive patients were prospectively studied. MEWS recorded on all end-point was ITU HDU. RESULTS Fifty-seven (17%) triggered call-out algorithm by scoring four more MEWS. Emergency likely trigger...
<h3>Importance</h3> For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes be less painful than larger tubes, but efficacy in has not been proven. <h3>Objective</h3> To assess the effect tube size and analgesia (NSAIDs vs opiates) on pain clinical related to patients with effusion. <h3>Design, Setting, Participants</h3> A 2×2 factorial phase 3 randomized trial among 320 requiring...
Background Pleural infection is common, and has a >30% major morbidity mortality—particularly when caused by Gram-negative, Staphylococcus aureus or mixed aerobic pathogens. Standard pleural fluid culture negative in ∼40% of cases. Culturing blood bottles may increase microbial yield, cheap easy to perform. Objectives To determine whether inoculating into increases the positivity over standard laboratory culture, assess optimum volume inoculum introduce. Methods 62 patients with were...
<h3>Background</h3> Community-acquired pneumonia (CAP) is a major cause of mortality and morbidity in many countries but few recent large-scale studies have examined trends its incidence. <h3>Methods</h3> Incidence CAP leading to hospitalisation one UK region (Oxfordshire) was calculated over calendar time using routinely collected diagnostic codes, modelled piecewise-linear Poisson regression. Further models considered other related diagnoses, typical administrative outcomes, blood...
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed assess whether successful awake COVID-19, respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) a high-dependency unit (HDU), associated improved outcomes. HDU care included by physiotherapists....
Rationale: Assessing the early use of video-assisted thoracoscopic surgery (VATS) or intrapleural enzyme therapy (IET) in pleural infection requires a phase III randomized controlled trial (RCT). Objectives: To establish feasibility randomization versus non-surgery as well key outcome measures which are important to identify relevant patient-centered outcomes RCT. Methods: MIST-3 was prospective multicenter All-comers with confirmed diagnosis were enrolled and those ongoing sepsis after up...
Rationale: Patients with malignant pleural effusion experience breathlessness, which is treated by drainage and pleurodesis. Incomplete results in residual dyspnea pleurodesis failure. Intrapleural fibrinolytics lyse septations within fluid, improving drainage.Objectives: To assess the effects of intrapleural urokinase on success patients nondraining effusion.Methods: We conducted a prospective, double-blind, randomized trial. were randomly allocated 1:1 ratio to (100,000 IU, three doses,...
Artificial intelligence (AI)-assisted image interpretation is a fast-developing area of clinical innovation. Most research to date has focused on the performance AI-assisted algorithms in comparison with that radiologists rather than evaluating algorithms' impact clinicians who often undertake initial routine practice. This study assessed diagnostic frontline acute care for detection pneumothoraces (PTX).