A5026999256- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Marriage and Sexual Relationships
- Neurological Complications and Syndromes
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Long-Term Effects of COVID-19
- Cancer Treatment and Pharmacology
The Ohio State University
2015-2024
Sylvester Comprehensive Cancer Center
2022
Oxford University Hospitals NHS Trust
2020-2022
Royal Marsden NHS Foundation Trust
2022
University Hospitals Coventry and Warwickshire NHS Trust
2018-2020
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
1999-2020
The Ohio State University Wexner Medical Center
2012-2020
University of Warwick
2018-2019
Coventry and Warwickshire Partnership NHS Trust
2019
Western Health and Social Care Trust
2018-2019
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed assess whether successful awake COVID-19, respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) a high-dependency unit (HDU), associated improved outcomes. HDU care included by physiotherapists....
We sought to reduce the risk of infectious complications and nonrelapse mortality (NRM) associated with use antithymocyte globulin (ATG) without compromising control acute graft-versus-host disease (aGVHD) in patients undergoing reduced-intensity conditioning (RIC) transplantation. As part an ongoing quality improvement effort, we lowered dose rabbit ATG from 7.5 mg/kg (R-ATG) (n = 39) 6.0 (r-ATG) 33) association fludarabine (Flu) busulfan (BU) RIC transplantation then monitored for adverse...
Autologous stem cell transplant (ASCT) is an effective treatment for multiple myeloma (MM). However, the timing of ASCT in era novel agents (lenalidomide, thalidomide, bortezomib) unknown. We retrospectively reviewed outcome patients with MM who received agent-based induction and first within 12 months diagnosis (early ASCT, n = 102) or at a later date (late 65). Median time to was 7.9 vs. 17.7 early late ASCT. The 3- 5-year overall survival (OS) from 90 63% 82 respectively (p 0.45)....
Summary Complex karyotype ( CK ) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia CLL patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for allogeneic stem cell transplant. Fifty‐one were analysed following transplant; 18‐month overall survival OS ), event‐free EFS and cumulative incidence of progression estimates 35%, 14% 63%, respectively, with n = 19) versus 83%, 68% 29% without 32) P ≤ 0·0001, 0·02)....
Infliximab, a chimeric monoclonal antibody (mAb) against tumor necrosis factor (TNF)-alpha, has shown activity steroid refractory acute graft-versus-host disease (aGVHD). We conducted prospective trial of infliximab for the prophylaxis aGVHD. Patients older than 20 years undergoing myeloablative allogeneic stem cell transplantation (SCT) hematologic malignancies were eligible. GVHD consisted given 1 day prior to conditioning and then on days 0, +7, +14, +28, +42, together with standard...
Digital communication between a patient and their clinician offers the potential for improved care, particularly young people with long term conditions who are at risk of service disengagement. However, its use raises number ethical questions which have not been explored in empirical studies. The objective this study was to examine, from perspective, implications digital clinical context living long-term conditions.
Patients with chemorefractory aggressive non-Hodgkin's lymphomas (NHL) generally have poor clinical outcomes available therapies. Allogeneic transplantation may be curative, but few studies are to guide transplant decision making in this setting. We examined allogeneic for 46 patients chemorefractory, NHL who had either stable disease (SD; n = 32) or progressive (PD; 14), respectively, following last salvage treatment. The median age was years (range: 22-63 years). Thirty-nine received...
Multiple myeloma (MM) represents 1.8% of all new cancer cases in the U.S. While not curable, advances treatment, including autologous stem cell transplant (ASCT) and maintenance therapy, have dramatically improved progression-free survival (PFS) overall (OS). We performed a retrospective analysis on newly diagnosed MM (NDMM) patients receiving ASCT from 1992−2016 at Ohio State University. A total 1001 consecutive NDMM were eligible. Patients split into five groups based historic changes...
PURPOSE We analyzed the safety and effectiveness of high-dose etoposide (2 g/m2) followed by granulocyte colony-stimulating factor (G-CSF) as a peripheral-blood progenitor cell (PBPC) mobilization regimen assessed extent tumor reduction in patients with breast cancer, non-Hodgkin's lymphoma (NHL), Hodgkin's disease (HD). PATIENTS AND METHODS One hundred sixty-nine consecutive who eventually underwent PBPC transplantation received treatment daily G-CSF (5 microg/kg). RESULTS This method was...
OBJECTIVES: The authors examined whether African Americans, compared with whites, received guideline-concordant care for bipolar I disorder. METHODS: A retrospective analysis was conducted of data patients who a diagnosis disorder in fiscal year 2001 and facilities the Department Veterans Affairs (VA) mid-Atlantic region. Indicators were based on prescription utilization inpatient outpatient services from VA databases. RESULTS: total 2,316 identified. Their mean age 52 years; 9.4 percent...
The appropriate dose of antithymocyte globulin (ATG) to be utilized in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplant (alloHSCT) is as yet unknown. We retrospectively compared patients who received 7.5 mg/kg (R-ATG, 39 patients) and 6 (r-ATG, 97 patients). cumulative incidences acute graft-versus-host disease (aGVHD) grade II-IV at 180 days were 46% 41% aGVHD III-IV 11% 18% r-ATG R-ATG, respectively (p > 0.30). respective estimated 24 months cGVHD 42% 44%...
Background Young people (aged 16–24 years) with long-term health conditions tend to disengage from services, resulting in poor outcomes. They are prolific users of digital communications. Innovative UK NHS clinicians use communication these young people. The plans patients more widely. Objectives To explore how health-care engagement can be improved using clinical (DCC); understand effects, impacts, costs and necessary safeguards; provide critical analysis its use, monitoring evaluation....
Abstract Background Systemic light chain (AL) amyloidosis is a clonal plasma‐cell neoplasm that carries poor prognosis. Although AL and Multiple Myeloma (MM) can co‐exist share various cytogenetic chromosomal abnormalities, little known about Fluorescent in situ hybridization (FISH) its prognostic relevance amyloidosis. Aim: The study aims to evaluate the most prevalent FISH abnormalities patients as independent factors, assess impact of cytogenetics on survival high‐risk cardiac patients....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOhioensins and Pallidisetins: Novel Cytotoxic Agents from the Moss Polytrichum pallidisetumGuo-Qiang Zheng, David K. Ho, Patrick J. Elder, Ralph E. Stephens, Charles Cottrell, John M. CassadyCite this: Nat. Prod. 1994, 57, 1, 32–41Publication Date (Print):January 1994Publication History Published online1 July 2004Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/np50103a005https://doi.org/10.1021/np50103a005research-articleACS...