A5011431831- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- CNS Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Hemoglobinopathies and Related Disorders
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
Case Western Reserve University
2024-2025
South Nassau Communities Hospital
2025
Cleveland Clinic Lerner College of Medicine
2025
Cleveland Clinic
2015-2024
University of Edinburgh
2024
Case Comprehensive Cancer Center
2011-2020
Levine Cancer Institute
2019
Cancer Institute (WIA)
2010-2018
University Hospitals Seidman Cancer Center
2018
Rush University Medical Center
2018
Infection of soybean roots by nitrogen-fixing Bradyrhizobium japonicum leads to expression plant nodule-specific genes known as nodulins. Nodulin 26, a member the major intrinsic protein/aquaporin (AQP) channel family, is component symbiosome membrane (SM) that encloses rhizobium bacteroid. To investigate water and solute transport characteristics nodulin we purified protein from SMs reconstituted it into carboxyfluorescein-loaded liposomes for studies using stopped-flow spectrofluorimetry....
Upon infection of soybean roots, nitrogen-fixing bacteria become enclosed in a specific organelle known as the symbiosome. The symbiosome membrane (SM) is selectively permeable barrier that controls metabolite flux between plant cytosol and symbiotic bacterium inside. Nodulin 26 (NOD 26), member aquaporin (AQP) water channel family, major protein component SM. Expression NOD Xenopus oocytes gave mercury-sensitive increase osmotic permeability (Pf). To define biophysical properties channels...
Summary Elevated pretransplant serum ferritin levels have been associated with an increased incidence of morbidity and mortality after allogeneic haematopoietic stem cell transplantation (HCT). We studied 222 patients who underwent myeloablative HCT in whom pretransplantation were available. Pretransplantation > 1910 μg/l was lower overall survival ( P = 0·003), relapse‐free decreased chronic graft‐ versus ‐host disease (GVHD) 0·019) non‐relapse (NRM) 0·042). Similar results obtained when...
Mutational inactivation in cancer of key apoptotic pathway components, such as TP53/p53, undermines cytotoxic therapies that aim to increase apoptosis. Accordingly, TP53 mutations are reproducibly associated with poor treatment outcomes. Moreover, treatments destroy normal stem cells intact p53 systems, a problem especially for myeloid neoplasms, these reverse the low blood counts cause morbidity and death. Preclinical studies suggest noncytotoxic concentrations DNA methyltransferase 1...
Allogeneic T lymphocytes can induce regression of metastatic breast cancer through an immune-mediated graft-versus-tumor (GVT) effect in murine models. To determine if a clinical GVT exists against cancer, allogeneic were used as adoptive cellular therapy after reduced-intensity chemotherapy conditioning regimen and hematopoietic stem-cell transplantation (HSCT) from human leukocyte antigen-matched siblings.Sixteen patients with that had progressed treatment anthracyclines, taxanes, hormonal...
Morbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy. Interleukin-7 (IL-7), principal homeostatic cytokine for T cells, is required GVHD in murine models. In contrast inflammatory cytokines (eg, IL-2, tumor necrosis factor alpha), IL-7 has not been studied extensively clinical transplant setting relative its relationship with GVHD.We evaluated association serum levels 31 patients who were...
The NCCN Clinical Practice Guidelines in Oncology for Hodgkin Lymphoma (HL) provide recommendations the management of adult patients with HL. Panel meets at least annually to review comments from reviewers within Member Institutions, examine relevant data, and reevaluate update recommendations. These Insights summarize recent updates centered on treatment considerations relapsed/refractory classic
Because natural killer (NK) cells can be potent anti-tumor effectors after allogeneic stem cell transplantation, we investigated NK reconstitution and receptor expression in patients undergoing hematopoietic focusing on the activating receptors that trigger responses. We determined levels peri-transplant period were inversely proportional to dramatic rise fall plasma of homeostatic cytokine IL-15, which increased more than 50-fold from pretreatment day transplant during lymphoreductive...
<h2>Abstract</h2> High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is frequently performed in patients with hematologic malignancies. ASCT can result significant nausea, pain, and discomfort. Supportive care has improved, pharmacologic therapies are used, but limitations. Music been demonstrated to improve nausea pain undergoing chemotherapy, little data available regarding the effects of music therapy setting. In a prospective study, lymphoma or multiple...
Magnetic resonance imaging (MRI) during pregnancy is a growing diagnostic modality for variety of different indications including fetal anomalies and maternal masses. A literature search did not find any case reports diagnosing short cervix on MRI before 20 weeks gestation. 34-year-old female underwent magnetic further evaluation known ovarian cyst which demonstrated multiseptated cystic mass measuring 15.5 × 9.9 18.5 cm in the right adnexa at 19 An incidental finding "bulging membranes into...
Vitamin D (VD) deficiency can cause osteomalacia, bone pain, muscle weakness, fatigue, and increased risk of fracture, may precipitate or exacerbate osteopenia osteoporosis. Patients receiving treatment for acute myeloid leukemia (AML) lymphoblastic (ALL) have limited exposure to sunlight often experience gastrointestinal side effects that decrease their ability maintain an adequate VD level. We hypothesized patients with AML ALL would a low level after allogeneic hematopoietic cell...
Summary High dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the preferred treatment modality for patients with relapsed or refractory diffuse large B‐cell lymphoma (DLBCL). To assess long‐term outcomes of these patients, we retrospectively analysed data from 309 consecutive who underwent ASCT DLBCL between 1994 and 2006. We found that non‐relapse mortality (NRM) became major cause death beginning approximately 8 years after ASCT. The most common causes NRM...
International prognostic index (IPI) has remained the primary tool in diffuse large B cell lymphoma (DLBCL) for more than 20 years. Even though disease is common older population, impact of comorbidities, dose reductions, and treatment-related adverse events (TAEs) on outcome elderly DLBCL patients not been well established. We studied 413 consecutive aged ≥ 60 years who were treated at Cleveland Clinic. The median age diagnosis was 69 years, 58% had high IPI score, 85% low Charlson...
Elevated serum ferritin is associated with reduced survival following allogeneic transplantation and an increased risk of toxic infectious complications after autologous hematopoietic stem cell (ASCT). We studied 315 patients who underwent ASCT for Hodgkin (HL) or non-Hodgkin lymphoma (NHL) at our institution in whom pretransplantation was available to determine its association survival. On multivariate analysis, a ferritin>685 ng/mL significantly lower overall (OS; P=.002) relapse-free...