A5011416204- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Healthcare cost, quality, practices
- Obesity and Health Practices
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- COVID-19 and healthcare impacts
- Cancer Risks and Factors
- Dialysis and Renal Disease Management
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Body Composition Measurement Techniques
- Economic and Financial Impacts of Cancer
- Colorectal and Anal Carcinomas
- Eating Disorders and Behaviors
- Healthcare Policy and Management
- Emergency and Acute Care Studies
- Primary Care and Health Outcomes
University of Oxford
2016-2025
Oxford University Hospitals NHS Trust
2024
Abbott (United Kingdom)
2024
Oxford BioMedica (United Kingdom)
2020-2023
Primary Health Care
2011-2023
Nuffield Health
2014-2022
National Institute for Health Research
2010-2018
University of Aberdeen
2018
University of Johannesburg
2018
University of Bristol
2018
BackgroundCurrent UK vaccination policy is to offer future COVID-19 booster doses individuals at high risk of serious illness from COVID-19, but it still uncertain which groups the population could benefit most. In response an urgent request Joint Committee on Vaccination and Immunisation, we aimed identify factors for severe outcomes (ie, COVID-19-related hospitalisation or death) in who had completed their primary schedule received first vaccine.MethodsWe constructed prospective cohorts...
Analysis of circulating tumour DNA could stratify cancer risk in symptomatic patients. We aimed to evaluate the performance a methylation-based multicancer early detection (MCED) diagnostic test patients referred from primary care.
The English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening. Those found to have potentially sight-threatening diabetic retinopathy (STDR) referred surveillance clinics or Hospital Services.To determine whether personalised screening intervals cost-effective.Risk factors were identified Gloucestershire, UK using survival modelling. A probabilistic decision hidden (unobserved) Markov model with a...
Abstract Background Loss of skeletal muscle mass (SMM) increases the risk frailty and, together with excess fat (FM), is a factor for cardio‐metabolic disease. However, use body composition measurements in nutritional surveillance and routine clinical practice limited by lack reference data. Our aim was to produce age‐specific sex‐specific values SMM FM White ethnic adult population UK. Secondary objectives were examine tracking over time using subsample repeated measures assess validity...
Background Limited data are available regarding whether computer-aided diagnosis (CAD) improves assessment of malignancy risk in indeterminate pulmonary nodules (IPNs). Purpose To evaluate the effect an artificial intelligence-based CAD tool on clinician IPN diagnostic performance and agreement for both categories management recommendations. Materials Methods This was a retrospective multireader multicase study performed June July 2020 chest CT studies IPNs. Readers used only imaging...
Faecal immunochemical testing (FIT) is recommended by the National Institute for Health and Care Excellence (NICE) to triage symptomatic primary care patients further investigation of colorectal cancer.To ascertain diagnostic performance FIT in adult patients.Faecal samples from routine practice Oxfordshire, UK were analysed using HM-JACKarc method between March 2017 2020. Clinical details recorded. Patients followed up 36 months linked hospital records evidence benign serious (colorectal...
The SARS-CoV-2 pandemic has passed its first peak in Europe.To describe the mortality England and association with status other demographic risk factors.Cross-sectional analyses of people known Oxford RCGP Research Surveillance Centre (RSC) sentinel network.Pseudonymised, coded clinical data were uploaded from volunteer general practice members this nationally representative network (n = 4 413 734). All-cause was compared national rates for 2019, using a relative survival model, reporting...
Hypertension has been identified as a risk factor for coronavirus disease 2019 (COVID-19) and associated adverse outcomes. This study examined the association between preinfection blood pressure (BP) control COVID-19 outcomes using data from 460 general practices in England. Eligible patients were adults with hypertension who tested or diagnosed COVID-19. BP was defined by most recent reading within 24 months of index date (January 1, 2020). controlled (<130/80 mm Hg), raised (130/80-139/89...
Introduction Primary cam morphology is a mostly benign bony prominence that develops at the femoral head-neck junction of hip, but it highly prevalent in many athlete populations. In small proportion athletes for whom not benign, resulting hip osteoarthritis can be debilitating. Clinicians, athletes, patients and researchers do yet agree on important primary elements. We aimed to ascertain improve level agreement definitions, terminology, taxonomy imaging outcome measures. Methods To collect...
Failure to take medication reduces the effectiveness of treatment leading increased morbidity and mortality. We evaluated efficacy a consultation-based intervention support objectively-assessed adherence oral glucose lowering (OGLM) compared usual care among people with type 2 diabetes. This was parallel group randomised trial in adult patients diabetes HbA1c≥7.5% (58 mmol/mol), prescribed at least one OGLM. Participants were allocated clinic nurse delivered, innovative strengthen patient...
Background Multiple myeloma is a haematological cancer characterised by numerous non-specific symptoms leading to diagnostic delay in large proportion of patients. Aim To identify which blood tests are useful suggesting or excluding diagnosis myeloma. Design and setting A matched case–control study set UK primary care using routinely collected data from the Clinical Practice Research Datalink. Method Symptom prevalence were analysed up 5 years before 2703 cases 12 157 controls. Likelihood...
Introduction Cancer survival in England lags behind most European countries, due partly to lower rates of early stage diagnosis. We report the protocol for evaluation a multidisciplinary diagnostic centre-based pathway investigation ‘low-risk but not no-risk’ cancer symptoms called Suspected CANcer (SCAN) pathway. SCAN is new standard care being implemented Oxfordshire; one number pathways during second wave Accelerate, Coordinate, Evaluate (ACE) programme, an initiative which aims improve...
We aimed to understand the time period of cancer diagnosis and types detected in primary care patients with unexpected weight loss (UWL) inform guidelines.This retrospective matched cohort study used registry linked electronic health records from UK's Clinical Practice Research Datalink between 2000 2014. Univariable multivariable time-to-event analyses examined association UWL, all cancers combined, site stage.In all, 63,973 had UWL recorded, whom 1375 (2.2%) were diagnosed within 2 years...
Artificial intelligence (AI)-assisted image interpretation is a fast-developing area of clinical innovation. Most research to date has focused on the performance AI-assisted algorithms in comparison with that radiologists rather than evaluating algorithms' impact clinicians who often undertake initial routine practice. This study assessed diagnostic frontline acute care for detection pneumothoraces (PTX).
To describe the level of overdetection people would find acceptable in screening for breast, prostate, and bowel cancer whether acceptability is influenced by magnitude benefit from specific harms overdetection.Online survey. Women were presented with scenarios on breast cancer, men prostate cancer. For each particular we epidemiological information described treatment its consequences. Secondly, two different benefit: one indicating a 10% reduction mortality second 50% reduction.Online...
The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that reduces mortality. In this retrospective cohort study from 1999 2013, we assessed during first year after diagnosis all-cause cancer-specific Of 2882 lung, 757 upper aero-digestive tract (UAT) 1733 bladder patients 27%, 29% 21% of UAT quit smoking. lung quit, mortality significantly lower (HR: 0.82 (0.74–0.92), while 0.89 (0.76–1.04) death due index 0.90 (0.77–1.05)...
Cam morphology, a distinct bony morphology of the hip, is prevalent in many athletes, and risk factor for hip-related pain osteoarthritis. Secondary cam due to existing or previous hip disease (eg, Legg-Calve-Perthes disease), well-described. not clearly associated with challenging concept clinicians, scientists patients. We propose this which likely develops during skeletal maturation as physiological response load, should be referred primary morphology. The aim study was introduce clarify...