Oliver van Hecke
A5057054298- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Patient Satisfaction in Healthcare
- Emergency and Acute Care Studies
- Pain Mechanisms and Treatments
- Healthcare Systems and Technology
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Pediatric Pain Management Techniques
- Respiratory viral infections research
- Musculoskeletal pain and rehabilitation
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- Antibiotics Pharmacokinetics and Efficacy
- Restraint-Related Deaths
- Pain Management and Opioid Use
- Mental Health and Patient Involvement
- Health, psychology, and well-being
- Cystic Fibrosis Research Advances
Ghent University
2024-2025
University of Oxford
2014-2024
Nuffield Health
2019-2024
National Institute for Health Research
2021
Royal College of General Practitioners
2021
Imperial College London
2021
The University of Queensland
2021
UK Research and Innovation
2021
University of Dundee
2013-2017
Ninewells Hospital
2014
<h2>Summary</h2><h3>Background</h3> Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. We aimed assess the effectiveness of azithromycin suspected COVID-19 among people in who had increased risk complications. <h3>Methods</h3> In this UK-based, primary care, open-label, multi-arm, adaptive platform trial interventions against at adverse clinical course (PRINCIPLE),...
Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days SARS-CoV-2 symptoms randomised to receive (n = 253) or Usual Care 324) were recruited study viral dynamics on whole genome sequence from 1437 genomes. Molnupiravir accelerates load decline, but virus is detectable by Day most cases. At 14 (9 post-treatment), associated with significantly higher persistence lower...
Chronic pain is common and complex has a large impact on individuals society. Good epidemiological data provide key information the use of resources (both in general practice specialist clinics), insight into factors that lead to or favour chronicity design interventions aimed at reducing preventing effects chronic pain. This review aims highlight important associated with pain, including those which are amenable lifestyle intervention.
To better understand the efficacy of various implementation strategies, improved methods for describing and classifying nature these strategies are urgently required. The aim this study was to develop pilot feasibility a taxonomy classify content strategies.A draft developed based on Cochrane Effective Practice Organisation Care (EPOC) data collection checklist. had four domains (professional, financial, organisational regulatory) covering 49 distinct strategies. We piloted by using it...
Background Depression and chronic pain are the two most important causes of disability (Global Burden Disease Study 2013). They occur together more frequently than expected both conditions have been shown to be co-morbid with cardiovascular disease. Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain co-morbidity these three conditions, we hypothesised that long-term, highly prevalent co-occur may due familial risk, and/or genetic factors. Methods findings...
Background: The safety, effectiveness and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, in patients the community who are multiply-vaccinated at increased risk morbidity mortality from COVID-19, has not been established. We aimed to determine whether molnupiravir added usual care reduced hospital admissions/deaths among people higher here report our preliminary analyses.Methods: Participants this UK multicentre, open-label, adaptive, multi-arm, platform,...
Hypertension has been identified as a risk factor for coronavirus disease 2019 (COVID-19) and associated adverse outcomes. This study examined the association between preinfection blood pressure (BP) control COVID-19 outcomes using data from 460 general practices in England. Eligible patients were adults with hypertension who tested or diagnosed COVID-19. BP was defined by most recent reading within 24 months of index date (January 1, 2020). controlled (<130/80 mm Hg), raised (130/80-139/89...
Background Colchicine has been proposed as a COVID-19 treatment. Aim To determine whether colchicine reduces time to recovery and COVID-19-related admissions hospital and/or deaths among people in the community. Design setting Prospective, multicentre, open-label, multi-arm, randomised, controlled, adaptive platform trial (PRINCIPLE). Method Adults aged ≥65 years or ≥18 with comorbidities shortness of breath, unwell for ≤14 days suspected community, were randomised usual care, care plus (500...
Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients community at increased risk morbidity mortality from COVID-19. Methods analysis PANORAMIC a UK-wide, open-label, prospective, adaptive, multiarm platform, randomised clinical trial that evaluates community. A master protocol governs addition new as they become available, introduction cessation existing interventions via interim...
The cost-effectiveness of molnupiravir, an oral antiviral for early treatment SARS-CoV-2, has not been established in vaccinated populations.
There remains public misconception about antibiotic use and resistance. Preschool children are at particular risk of receiving unnecessary antibiotics because they commonly present in primary care many childhood infections self-limiting. The aim our study was to explore parents' perceptions understanding resistance the context their young child with an acute respiratory tract infection (RTI) strategies parents would find acceptable minimize for families. Semi-structured interviews were...
Post herpetic neuralgia (PHN) is the most common complication of herpes zoster, also known as shingles. Amitriptyline has been postulated to prevent PHN. The objective determine whether prophylactic low-dose amitriptyline prevents PHN in patients newly diagnosed with This a multicentre, individually randomized, pragmatic, placebo-controlled superiority trial health economic analysis and nested qualitative study. Patients new-onset shingles are screened by treating clinicians participating...
Abstract BACKGROUND Inhaled budesonide has shown efficacy for treating COVID-19 in the community but not yet been tested effectiveness trials. METHODS We performed a multicenter, open-label, multi-arm, adaptive platform randomized controlled trial involving people aged ≥65 years, or ≥50 years with comorbidities, and unwell ≤14 days suspected (PRINCIPLE). Participants were to usual care, care plus inhaled (800µg twice daily 14 days), other interventions. The co-primary endpoints are time...