Lucy Cureton
A5069076021- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Long-Term Effects of COVID-19
- Pharmacological Receptor Mechanisms and Effects
- Cardiovascular Syncope and Autonomic Disorders
- Mobile Health and mHealth Applications
- Peripheral Neuropathies and Disorders
- Vaccine Coverage and Hesitancy
- Retinal and Optic Conditions
- Advanced Causal Inference Techniques
- Heparin-Induced Thrombocytopenia and Thrombosis
- Shoulder and Clavicle Injuries
- Adolescent and Pediatric Healthcare
- Myofascial pain diagnosis and treatment
- Multiple Sclerosis Research Studies
- Survey Methodology and Nonresponse
- Rheumatoid Arthritis Research and Therapies
- Antibiotic Use and Resistance
- Social Media in Health Education
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Sports injuries and prevention
- Healthcare Systems and Technology
University of Oxford
2017-2024
Nuffield Health
2022-2024
Nuffield Orthopaedic Centre
2017-2023
BackgroundImmunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses S1 receptor-binding domain (S1-RBD) SARS-CoV-2 spike protein compared with uninterrupted in patients immune-mediated inflammatory diseases.MethodsWe did an open-label, prospective, two-arm, parallel-group, multicentre, randomised, controlled, superiority trial...
BackgroundCorticosteroid injections and physiotherapy exercise programmes are commonly used to treat rotator cuff disorders but the treatments' effectiveness is uncertain. We aimed compare clinical cost-effectiveness of a progressive programme with single session best practice advice, or without corticosteroid injection, in adults disorder.MethodsIn this pragmatic, multicentre, superiority, randomised controlled trial (2 × 2 factorial), we recruited patients from 20 UK National Health...
Background: The safety, effectiveness and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, in patients the community who are multiply-vaccinated at increased risk morbidity mortality from COVID-19, has not been established. We aimed to determine whether molnupiravir added usual care reduced hospital admissions/deaths among people higher here report our preliminary analyses.Methods: Participants this UK multicentre, open-label, adaptive, multi-arm, platform,...
Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients community at increased risk morbidity mortality from COVID-19. Methods analysis PANORAMIC a UK-wide, open-label, prospective, adaptive, multiarm platform, randomised clinical trial that evaluates community. A master protocol governs addition new as they become available, introduction cessation existing interventions via interim...
The cost-effectiveness of molnupiravir, an oral antiviral for early treatment SARS-CoV-2, has not been established in vaccinated populations.
BackgroundMethotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate immediately after COVID-19 booster vaccination improved antibody response against S1 receptor binding domain (S1-RBD) SARS-CoV-2 spike protein live neutralisation compared with uninterrupted in patients diseases.MethodWe did multicentre, open-label, parallel-group, randomised, superiority trial secondary-care...
Background Rotator cuff-related shoulder pain is very common, but there uncertainty regarding which modes of exercise delivery are optimal and the long-term benefits corticosteroid injections. Objectives To assess clinical effectiveness cost-effectiveness progressive compared with best-practice physiotherapy advice, or without injection, in adults a rotator cuff disorder. Design This was pragmatic multicentre superiority randomised controlled trial (with 2 × factorial design). Setting Twenty...
Introduction Shoulder pain is very common, with around 70% of cases due to disorders the rotator cuff. Despite widespread provision physiotherapy, there uncertainty about which type exercise and delivery mechanisms are associated best outcomes. There also long-term benefits harms corticosteroid injection therapy, often used in addition physiotherapy. The Getting it Right: Addressing Pain trial will assess clinical cost-effectiveness individually tailored, progressive compared practice...
Objectives: Treating COVID-19 infection with antiviral drugs may reduce the longer-term impact of illness, but no randomised controlled trials have yet reported on effectiveness molnupiravir longer term outcomes. The main objective current research is to investigate effects for at 3- and 6-months post-randomisation.Design: Participants in this open-label trial were followed up 6-months. Bayesian analyses used estimate probability superiority (odds ratio <1 dichotomous outcomes).Setting:...
It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate 2-week interruption low-dose weekly methotrexate SARS-CoV-2 boosters enhances the immune response compared with continuing adults autoimmune inflammatory conditions. An open-label, pragmatic, prospective, parallel group, randomised controlled superiority trial internal feasibility assessment and nested...
Use of a person's name in text message has been shown to be effective instigating behaviour change. We evaluated the effectiveness personalised (including recipient's name) versus standardised for prompting response from trial participants complete and return postal follow-up questionnaires.
Abstract Background The antibacterial, anti-inflammatory and antiviral properties of azithromycin suggest therapeutic potential against COVID-19. Randomised data in mild-moderate disease are lacking. We assessed whether is effective reducing hospitalisation patients with Methods This open-label, randomised superiority clinical trial at 19 centres the United Kingdom enrolled adults, ≥18 years, presenting to hospitals clinically-diagnosed highly-probable or confirmed COVID-19 infection, <14...
Abstract Background The Getting it Right: Addressing Shoulder Pain (GRASP) trial assesses the clinical and cost-effectiveness of individually tailored, progressive exercise compared with best practice advice, or without corticosteroid injection, in adults a rotator cuff disorder. This article describes statistical analysis plan for GRASP randomised controlled trial. Methods/design is multicentre using 2 × factorial design. Adults aged ≥ 18 years new episode shoulder pain related to disorder,...
<h3>Background</h3> The antibacterial, anti-inflammatory and antiviral properties of azithromycin suggest therapeutic potential against COVID-19. Randomised data in mild-moderate disease are lacking. We assessed whether is effective reducing hospitalisation patients with <h3>Methods</h3> This open-label, randomised superiority clinical trial at 19 centres the United Kingdom enrolled adults, ≥18 years, presenting to hospitals clinically-diagnosed highly-probable or confirmed COVID-19...
Background: The antibacterial, anti-inflammatory and antiviral properties of azithromycin suggest therapeutic potential against COVID-19. Randomised data in mild-moderate disease are lacking. We assessed whether is effective reducing hospitalisation patients with Methods: This open-label, randomised superiority clinical trial at 19 centres the United Kingdom enrolled adults, ≥18 years, presenting to hospitals clinically-diagnosed highly-probable or confirmed COVID-19 infection, <14 days...
Abstract Background: Use of a person’s name in text message has been shown to be effective instigating behaviour change. We evaluated the effectiveness personalised (including recipient’s name), versus standardised for prompting response from trial participants complete and return postal follow-up questionnaires. Methods : Using randomised study within (SWAT) embedded host GRASP (Getting it Right: Addressing Shoulder Pain) trial, who provided mobile telephone number were (1:1) by central...