A5021589902- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Geriatric Care and Nursing Homes
- Microscopic Colitis
- Chronic Disease Management Strategies
- Antifungal resistance and susceptibility
- Pharmacology and Obesity Treatment
- Obesity, Physical Activity, Diet
- Data Quality and Management
- Aquaculture Nutrition and Growth
- Primary Care and Health Outcomes
- Health disparities and outcomes
- Clostridium difficile and Clostridium perfringens research
- Parasite Biology and Host Interactions
- Obesity and Health Practices
- Patient Satisfaction in Healthcare
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urinary Tract Infections Management
Public Health Agency
2012-2024
Queen's University Belfast
2007-2024
Environmental Protection Agency
2015-2022
Queens University
2022
Public Health England
2015-2019
University of Ulster
2015
Royal Victoria Hospital
2015
Medical College of Wisconsin
2014
United Kingdom Clinical Research Collaboration
2013
University of Wisconsin–Milwaukee
2013
BackgroundCurrent UK vaccination policy is to offer future COVID-19 booster doses individuals at high risk of serious illness from COVID-19, but it still uncertain which groups the population could benefit most. In response an urgent request Joint Committee on Vaccination and Immunisation, we aimed identify factors for severe outcomes (ie, COVID-19-related hospitalisation or death) in who had completed their primary schedule received first vaccine.MethodsWe constructed prospective cohorts...
BackgroundGenomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages their association patient groups (defined by demographic factors). In 2013, European gonococcal population was characterised genomically for first time. We describe in 2018 identify emerging or vanishing associated AMR characteristics of patients, elucidate recent...
Abstract Objectives Novel antimicrobials for treatment of gonorrhoea are imperative. The first-in-class spiropyrimidinetrione zoliflodacin is promising and currently in an international Phase 3 randomized controlled clinical trial (RCT) uncomplicated gonorrhoea. We evaluated the vitro activity genetic conservation target (GyrB) other potential resistance determinants among 1209 consecutive Neisseria gonorrhoeae isolates obtained from 25 EU/European Economic Area (EEA) countries 2018 compared...
Abstract The emergence of the COVID-19 vaccination has been critical in changing course pandemic. To ensure protection remains high vulnerable groups booster vaccinations UK have targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from 2021 Census linked to electronic health records. fitted cause-specific Cox models examine association between conditions risk death all-other-cause for adults aged 50-100-years England vaccinated...
We investigated the association between a wide range of comorbidities and COVID-19 in-hospital mortality assessed influence multi morbidity on risk COVID-19-related death using large, regional cohort 6036 hospitalized patients. This retrospective study was conducted Patient Administration System Admissions Discharges data. The International Classification Diseases 10th edition (ICD-10) diagnosis codes were used to identify common outcome measure. Individuals with lymphoma (odds ratio [OR],...
To evaluate the impact of COVID-19 pandemic on patterns antimicrobial use and incidence pathogens in primary secondary healthcare settings Northern Ireland.Data were collected antibiotic Gram-positive Gram-negative from Ireland for period before (January 2015-March 2020) during (April 2020-December 2021) pandemic. Time series intervention analysis methods utilized.In hospital setting, mean total consumption was 1864.5 defined daily doses (DDDs) per 1000 occupied-bed days (OBD), showing no...
UK COVID-19 vaccination policy has evolved to offering booster doses individuals at increased risk of severe Illness from COVID-19. Building on our analyses vaccine effectiveness first, second and initial doses, we aimed identify outcomes (i.e., related hospitalisation or death) post the autumn 2022 dose.
Peer-led interventions to improve chronic disease self-management can health outcomes but are not widely used. Therefore, we tested a peer-led hypertension intervention delivered at regular meetings of community veterans' organizations. We randomized 58 organizational units ("posts") organizations in southeast Wisconsin vs. professionally education. Volunteer peer leaders posts monthly presentations regarding during post meetings. representatives seminar encouraged members attend 3 didactic...
Three cases of meningitis due to multidrug-resistant serotype 14 Streptococcus pneumoniae occurred at a day care center (DCC) over 5 days. Cultures nasopharyngeal samples were done the index DCC, 2 comparison DCCs, and pediatrics practice. Isolates serotyped subtyped by pulsed-field gel electrophoresis (PFGE) with SmaI. Pneumococcal carriage rates ranged from 44%-65% 3 DCCs 29% in Carriage S. was noted 13%-19% children DCCs. An outbreak strain identified PFGE DCC 1 other DCC; closely related...
The number of confirmed positive tests various sexually transmitted infections has grown recently in the United Kingdom. objective this study is to propose a deterministic compartmental model investigate gonorrhoea spread Northern Ireland between 2012 and 2022. differential equation based includes both symptomatic asymptomatic spread, spontaneous recovery treatment compartments. After fitting our monthly new tests, we found that basic reproduction approximately 1.0030. In addition, derive...
Volunteer peer leaders (PLs) benefit from their involvement in health interventions but we know little about how they compare with other non-PL volunteers or the intervention recipients themselves. We randomized 58 veterans' service organizations' posts (e.g. VFW) to peer- versus professionally led self-management support interventions. Our primary research questions were whether hypertensive PLs changed over course of project, more than who not such a role [i.e. post representatives (PRs)]...
Obesity is a global public health problem. There are range of treatments available with varying short and long term success rates. One option the use anti-obesity medication prescription which has increased dramatically in recent years. Despite this, little known about individual GP practice factors that influence medication. Multi-level logistic regression analysis was used to investigate associated Northern Ireland using population primary care prescribing database (~1.5 million people...
In Northern Ireland there are concerns about candidaemia, with rates higher than those reported in England and Wales. Our aim was to explore the epidemiology of candidaemia during a 10 year period clinical management upon suspicion cases one enhanced investigation Ireland.Candidaemia reports Public Health Agency were validated 2002-2011 used examine incidence antifungal sensitivity trends (during 2007-2011). A proforma collate information for all patients 2011.The majority (96%) isolates...
There is a lack of consensus about which non-human immunodeficiency virus (HIV) patient groups would benefit from prophylaxis. Here, we analysed an enhanced Pneumocystis jirovecii database to describe the epidemiology pneumonia (PCP) and P. colonizations in Northern Ireland (NI) with view identifying risk who may prophylaxis.We prospectively collected information on demographics, clinical severity features for all hospital inpatients NI aged ≥18 years confirmed any respiratory tract sample....
Since April 2021, COVID-19 vaccines have been recommended for pregnant women. Despite this, vaccine uptake in this group is low compared to the non-pregnant population of childbearing age. Our aim was understand barriers and facilitators among women Northern Ireland using COM-B framework, so make recommendations public health interventions. The proposes that human behaviour influenced by extent which a person has capability, opportunity, motivation enact behaviour. Understanding factors...
We report an outbreak of four confirmed cases invasive pneumococcal disease (IPD) in individuals occupationally exposed to welding fumes, at a Belfast shipyard (Northern Ireland). All were hospitalised. A high-risk sub-group 679 workers has been targeted for antibiotic prophylaxis and vaccination. Physicians public health institutions outside Northern Ireland should be alert presenting with pneumonia or IPD recent links the shipyard, facilitate early assessment treatment.