A5102923567- Inflammatory Myopathies and Dermatomyositis
- Ion channel regulation and function
- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- Neonatal Health and Biochemistry
- Muscle metabolism and nutrition
- Ion Transport and Channel Regulation
- Cytomegalovirus and herpesvirus research
- Fatty Acid Research and Health
- Vitamin D Research Studies
- Erythrocyte Function and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Kawasaki Disease and Coronary Complications
- Celiac Disease Research and Management
- Technology Use by Older Adults
- Reproductive System and Pregnancy
- Dye analysis and toxicity
- Lipid Membrane Structure and Behavior
- Tea Polyphenols and Effects
- Poxvirus research and outbreaks
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Birth, Development, and Health
University of Rochester Medical Center
2007-2024
Public Health Agency
2023-2024
Queen's University Belfast
2019-2022
Northern Health and Social Care Trust
2022
University of Ulster
2015-2020
Food for Health Ireland
2015-2018
University of Rochester
2007-2008
Syracuse University
2004
Allegheny College
1997-1998
Instituto Nacional de Psiquiatría
1995
Between 7 and 25 May, 86 monkeypox cases were confirmed in the United Kingdom (UK). Only one case is known to have travelled a virus (MPXV) endemic country. Seventy-nine with information male 66 reported being gay, bisexual, or other men who sex men. This first sustained MPXV transmission UK, human-to-human through close contacts, including sexual networks. Improving ascertainment onward-transmission preventive measures are ongoing.
Abstract Childhood dermatomyositis is a distinct subset of with highly variable outcome. We reviewed our experience 29 patients observed over period 22 years and attempted to correlate tissue manifestations Distinctive vascular lesions included non‐necrotizing lymphocytic vasculitis unique spectrum endovascular injury producing temporary or permanent occlusion small arteries capillaries. Vessels noninflammatory endovasculopathy were often reactive fluorescein‐conjugated antisera IgM, C3d,...
Abstract The nailfold capillary pattern was observed in a population of patients with childhood dermatomyositis. Distinctive loop abnormalities were found 11 19 dermatomyositis and none 2 control populations ( P < 0.001). By retrospective analysis the patients, we that presence correlates more severe forms disease (ulcerative chronic types), as opposed to limited type disease. These changes occurred independently activity or cutaneous abnormalities.
Abstract The immunochemical specificity of the immunofluorescent Crithidia luciliae method for detection antibodies to double‐stranded DNA (dsDNA) was confirmed by demonstrating abolition staining DNase digestion and absorption with dsDNA. This less sensitive than a Millipore filter detecting DNA. It positive only in subjects systemic lupus erythematosus or drug‐induced antinuclear factors. technique appears suitable study characteristics
To evaluate the impact of COVID-19 pandemic on patterns antimicrobial use and incidence pathogens in primary secondary healthcare settings Northern Ireland.Data were collected antibiotic Gram-positive Gram-negative from Ireland for period before (January 2015-March 2020) during (April 2020-December 2021) pandemic. Time series intervention analysis methods utilized.In hospital setting, mean total consumption was 1864.5 defined daily doses (DDDs) per 1000 occupied-bed days (OBD), showing no...
Typing for HLA‐A and ‐B antigens was performed on 87 children with definite juvenile dermatomyositis (JDMS). A significantly increased frequency of HLA‐B8 (estimated relative risk = 2.8, P c < 0.01) observed among White patients, but not Blacks or Latin Americans JDMS. No abnormality HLA haplotype segregation 38 healthy siblings the JDMS probands.
Summary The anti‐diabetic actions of a boarfish protein hydrolysate ( BPH ) were investigated in cultured cells and mice. A Capros aper muscle was generated using the enzymes Alcalase 2.4 L Flavourzyme 500 L. Furthermore, subjected to simulated gastrointestinal digestion SGID ). samples (0.01–2.5 mg mL −1 tested vitro for DPP ‐ IV inhibition insulin GLP ‐1 secretory activity from BRIN BD 11 GLUT ag cells, respectively. samples, caused dose‐dependent increase (4.2 5.3‐fold, P < 0.001)...
Colorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet an important modifiable risk factor. Processed meat consumption, including meats with preservative salts such as sodium nitrite, have been implicated CRC pathogenesis. This study investigated how pathology metabolic status of adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mice was perturbed following 8 weeks pork consumption. Dietary inclusions (15%) either nitrite-free pork, sausage, or...
Abstract Ninety children with definite juvenile dermatomyositis (JDMS), who had been HLA typed, were tested for the presence of tissue or organ‐specific antibodies. Sixty active disease at time study. The mean duration was 4 years, and 30 soft calcifications. following autoantibodies sought: thyroid, gastric parietal cells, smooth muscle, striated microsomes, mitochondria, DNA, extractable nuclear antigen, Sm, PM‐1, antinuclear antibody (ANA), rheumatoid factor. Only ANA PM‐1 more frequent...
A hallmark of human cytomegalovirus (HCMV) infection is the characteristic enlargement host cells (i.e., cytomegaly). Because iron (Fe) required for cell growth and Fe chelators inhibit viral replication, we investigated effects HCMV on homeostasis in MRC-5 fibroblasts. Using metallosensitive fluorophore calcein chelator salicylaldehyde isonicotinoyl hydrazone (SIH), labile pool (LIP) mock-infected was determined to be 1.04 ± 0.05 μM. Twenty-four hours postinfection (hpi), size LIP had...
The effects of human cytomegalovirus (HCMV) infection on Cl − /[Formula: see text]exchanger activity in lung fibroblasts (MRC-5 cells) were studied using fluorescent, ion-sensitive dyes. intracellular pH (pH i ) mock- and HCMV-infected cells bathed a solution containing 5% CO 2 -25 mM[Formula: text] nearly the same. However, replacement external with gluconate caused an H DIDS-inhibitable (100 μM) increase but not mock-infected cells. Continuous exposure to hyperosmotic media text]caused...
Abstract Sera from 34 patients with juvenile rheumatoid arthritis (JRA), 31 systemic lupus erthematosus (SLE), and 22 normal controls were studied for microcytotoxicity before after clearing in the ultracentrifuge. Normal T cells as well Tγ non‐Tγ subpopulations used. Before ultracentrifugation all test sera showed apparent cell specificity assay where rabbit complement was added. JRA SLE produced much higher proportions of killing than controls. Ultracentrifugal resulted marked diminution...
Problem Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined association between maternal MeHg, polyunsaturated fatty acids ( PUFA ), and markers (Th1:Th2; TNF ‐α, IL ‐1β, IFN ‐γ, ‐2, ‐4, ‐5, ‐10, MCP ‐1, TARC , sF lt‐1, VEGF‐D CRP ‐6) at 28 weeks’ gestation. Linear regression associations MeHg without adjustment for . Results all models, as...