A5083993753- Birth, Development, and Health
- Fatty Acid Research and Health
- Pregnancy and preeclampsia studies
- Per- and polyfluoroalkyl substances research
- Reproductive System and Pregnancy
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Diet, Metabolism, and Disease
- Mercury impact and mitigation studies
- Pregnancy and Medication Impact
- Infant Nutrition and Health
- Eicosanoids and Hypertension Pharmacology
- Vitamin D Research Studies
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
University of Ulster
2018-2025
Food for Health Ireland
2018
Abstract Background Studies investigating associations between prenatal polyunsaturated fatty acid status (PUFAs), in particular the anti‐inflammatory n‐3 PUFAs, and development of childhood asthma have yielded conflicting results. Objective To determine maternal fish intake (a rich source PUFAs), or cord PUFAs with prevalence a high fish‐eating population. Methods We examined these PUFA concentrations Seychelles Child Development Study Nutrition Cohort 2, large observational study Maternal...
Abstract Purpose Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic (ALA) in a pathway involving the desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA their richest source fish preferred. This study investigated effect consumption on PUFA concentrations women childbearing age while stratifying by FADS genotype. The influence lipid profile, markers inflammation...
Problem Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined association between maternal MeHg, polyunsaturated fatty acids ( PUFA ), and markers (Th1:Th2; TNF ‐α, IL ‐1β, IFN ‐γ, ‐2, ‐4, ‐5, ‐10, MCP ‐1, TARC , sF lt‐1, VEGF‐D CRP ‐6) at 28 weeks’ gestation. Linear regression associations MeHg without adjustment for . Results all models, as...
Exposure to the environmental toxicant mercury (Hg) has been associated with immune dysregulation, including autoimmune disease, but few human studies have examined methylmercury (MeHg) exposure from fish consumption.We associations between MeHg and biological markers of autoimmunity inflammation while adjusting for long chain polyunsaturated fatty acids (LCPUFA).At age 19 years, hair total Hg (Y19Hg), LCPUFA status, a panel 13 antinuclear antibodies (ANA), serum immunoglobulins (Ig) IgG,...
Dietary intake can influence immune function indirectly by affecting the gut microbiota composition and metabolism (1) . Fish consumption has been shown to positively regulate in humans (2,3) ;albeit those studies fish was consumed high amounts (500-750g/week) not investigated. This study investigated effect of consuming UK dietary recommendation for (4) (2 portions [140-280g/week], one which is oily) on alpha diversity. Further, we examined if changes (pre- post-intervention) were...
Abstract Optimal maternal long-chain PUFA (LCPUFA) status is essential for the developing fetus. The fatty acid desaturase (FADS) genes are involved in endogenous synthesis of LCPUFA. minor allele various FADS SNP have been associated with increased concentrations precursors linoleic (LA) and α-linolenic (ALA), lower arachidonic (AA) DHA. There limited research on influence genotype cord status. current study investigated child genetic variation blood a high fish-eating cohort. Cord samples...
Abstract The association of MeHg exposure through fish consumption on human autoimmunity remains unclear. Fish also contain n-3 long chain polyunsaturated fatty acids (LCPUFA) that are known to regulate inflammation and mitigate autoimmune disease symptoms. We studied the low-level methylmercury (MeHg) in SCDS. examined this at age 19 years SCDS Main Cohort (n = 497). measured 3 time points [prenatal, weighted average (6 months years) concurrent (19 LCPUFA status a panel 13 markers years....