A5054850896- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Climate Change and Health Impacts
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Effects and risks of endocrine disrupting chemicals
- Air Quality Monitoring and Forecasting
- Energy and Environment Impacts
- Fatty Acid Research and Health
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Toxic Organic Pollutants Impact
- Bayesian Methods and Mixture Models
- Advanced Causal Inference Techniques
- Per- and polyfluoroalkyl substances research
- Vehicle emissions and performance
- Prenatal Substance Exposure Effects
- Global Health Care Issues
- Noise Effects and Management
- Epigenetics and DNA Methylation
- Child Nutrition and Water Access
- Economic and Environmental Valuation
- Environmental Justice and Health Disparities
University of Rochester Medical Center
2016-2025
University of Rochester
2015-2024
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Boston University
2018
Ministry of Health
2012-2015
University of Ulster
2012-2015
Food for Health Ireland
2015
University of Alaska System
2012
Cornell University
2012
There is concern over potential neurobehavioral effects of prenatal phthalate exposures, but available data are inconsistent.
BACKGROUND: DNA adducts formed as a consequence of exposure to tobacco smoke may be involved in carcinogenesis, and their presence indicate high risk lung cancer. To determine whether can used "dosimeter" for cancer risk, we measured the adduct levels nontumorous tissue blood mononuclear cells from patients with cancer, collected data on history smoking. METHODS: We 32 P-postlabeling assay measure aromatic hydrophobic 143 54 these patients. From smoking histories, identified variables...
Organochlorines are environmentally persistent contaminants that readily cross the placenta, posing a potential risk to developing fetus. Evidence for neurodevelopmental effects at low levels of these compounds is growing, though few studies have focused on behavioral outcomes. The authors investigated association between prenatal polychlorinated biphenyl (PCB) and p,p′-dichlorodiphenyl dichloroethylene (p,p′-DDE) behaviors associated with attention deficit hyperactivity disorder (ADHD),...
Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few examined relationship between human exposure to BPA male reproductive function.We investigated relationships environmental parameters, including semen quality hormones, prospectively recruited fertile men.Participants (n = 375) were partners pregnant women who participated Study for Future Families four U.S. cities, all men provided blood, semen, urine samples. was measured urine. Serum samples...
To allow for non-linear exposure-response relationships, we applied flexible non-parametric smoothing techniques to models of time lung cancer mortality in two occupational cohorts with skewed exposure distributions. We focused on three different Cox models: penalized splines, restricted cubic and fractional polynomials. compared standard software implementations these methods based their visual representation criterion model selection. propose a measure the difference between pair curves...
To investigate the association of prenatal mercury exposure and fish intake with attention-deficit/hyperactivity disorder (ADHD)-related behavior.For a population-based prospective birth cohort recruited in New Bedford, Massachusetts (1993-1998), we analyzed data for children examined at age 8 years peripartum maternal hair measures (n = 421) or report consumption during pregnancy 515). Inattentive impulsive/hyperactive behaviors were assessed using teacher rating scale neuropsychological...
Previous studies have reported decreased birth weight associated with increased air pollutant concentrations during pregnancy. However, it is not clear when pregnancy increases in pollution are the largest differences weight.Using natural experiment of declines 2008 Beijing Olympics, we evaluated whether having specific months (i.e., 1st…8th) Olympics period was larger weights, compared pregnancies same dates 2007 or 2009.Using n = 83,672 term births to mothers residing four urban districts...
Rationale: Fine particulate matter air pollution of 2.5 μm or less in diameter (PM2.5) has been associated with an increased risk respiratory disease, but assessments specific infections adults are lacking.Objectives: To estimate the rate infection healthcare encounters acute increases PM2.5 concentrations.Methods: Using case–crossover methods, we studied 498,118 adult New York State residents a primary diagnosis influenza, bacterial pneumonia, culture-negative pneumonia upon hospitalization...
The response of respiratory infections to source-specific particulate matter (PM) is an area active research. Using PM2.5 concentrations at six urban sites in New York State, a case-crossover design, and conditional logistic regression, we examined the association between PM rate hospitalizations emergency department (ED) visits for influenza or culture-negative pneumonia from 2005 2016. There were most N = 14 764 hospitalizations, 57 522 ED visits, 274 226 113 997 included our analyses. We...
Previous studies reported triggering of acute cardiovascular events by short-term increasedPM2.5 concentrations. From 2007 to 2013, national and New York state air quality policies economic influences resulted in reduced concentrations PM2.5 other pollutants across the state. We estimated rate hospital admissions associated with increased previous 1-7 days, evaluated whether they differed before (2005-2007), during (2008-2013), after these concentration changes (2014-2016).Using Statewide...
Previous work reported increased rates of acute cardiovascular hospitalizations associated with PM2.5 concentrations in the previous few days across urban centers New York State from 2005 to 2016. These relative were higher after air quality policies and economic changes resulted decreased PM composition (e.g. secondary organic carbon), compared before during these changes. Changes sources may explain this difference.To estimate rate increases source specific concentrations.Using apportioned...
Prior studies reported that exposure to increased concentrations of fine particulate matter (PM2.5) were associated with rates hospitalization and emergency department (ED) visits for asthma chronic obstructive pulmonary disease (COPD). In this study, examined from 2005 2016 using a case-crossover design ascertain if there have been changes in the per unit mass given substantial reductions PM2.5 concentration its composition. reduced through combination policies designed improve air quality...
Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) variations are linked to age-related diseases associated with environmental exposure nutritional status. Limited data, however, exist on the associations mercury exposure, particularly early in life.
We previously reported associations between organochlorines and behaviors related to attention deficit hyperactivity disorder among boys girls at 8 years of age using a teacher's rating scale for birth cohort in New Bedford, Massachusetts (USA).Our goal was corroborate these findings neuropsychological measures inattentive impulsive behaviors.We investigated the association cord serum polychlorinated biphenyls (PCBs) p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE) impulse control...
In clinical settings it is usually recommended that at least 2 semen samples are obtained, because this decreases the error rate in classifying men as fertile, subfertile, or infertile (Berman et al, 1996; World Health Organization, 1999; Sharlip 2002). fact, some authors have 3 be collected of large within-man variability parameters (Keel, 2006). our prospective study quality partners pregnant women (the Study for Future Families, SFF), we requested from each participant order to reduce...
Human endothelial and lung epithelial cells were exposed to nanosized Pt shapes following acellular analyses of their oxidant potential. Despite clear evidence particle uptake by cells, the nanoparticles not found induce cytotoxicity or oxidative stress in either cell type. Results from vivo respiratory tract exposures suggest that particles are retained tissue minimal-mild inflammation results exposure particles.
Abstract The generalized linear mixed‐effects model (GLMM) is a popular paradigm to extend models for cross‐sectional data longitudinal setting. When applied modeling binary responses, different software packages and even procedures within package may give quite results. In this report, we describe the statistical approaches that underlie these discuss their strengths weaknesses when fit correlated responses. We then illustrate considerations by applying implemented in some simulated real...