Beata Młynarczyk-Bonikowska
A5014302662- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Autoimmune Bullous Skin Diseases
- Polish Law and Legal System
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Medicine and Dermatology Studies History
- Spectroscopy Techniques in Biomedical and Chemical Research
- Antimicrobial Resistance in Staphylococcus
- Genetic factors in colorectal cancer
- Biosensors and Analytical Detection
- Reproductive Health and Contraception
- Parvovirus B19 Infection Studies
- Genital Health and Disease
- Dermatological and Skeletal Disorders
- Microbial infections and disease research
- Microbial Natural Products and Biosynthesis
- Cutaneous lymphoproliferative disorders research
- Bacterial Identification and Susceptibility Testing
- Cervical Cancer and HPV Research
- Urticaria and Related Conditions
- Polish Legal and Social Issues
- Bartonella species infections research
- Bee Products Chemical Analysis
Medical University of Warsaw
2014-2024
Postgraduate School of Molecular Medicine
2019
Queensland University of Technology
2015
BackgroundGenomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages their association patient groups (defined by demographic factors). In 2013, European gonococcal population was characterised genomically for first time. We describe in 2018 identify emerging or vanishing associated AMR characteristics of patients, elucidate recent...
BackgroundRegular quality-assured whole-genome sequencing linked to antimicrobial resistance (AMR) and patient metadata is imperative elucidate the shifting gonorrhoea epidemiology, both nationally internationally. We aimed examine gonococcal population in European Economic Area (EEA) 2020, emerging disappearing lineages associated with AMR metadata, compare 2013 2018 data, explain changes epidemiology.MethodsIn this retrospective genomic surveillance study, we analysed consecutive isolates...
To elucidate the genome-based epidemiology and phylogenomics of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae strains collected in 2009-14 Europe clarify azithromycin resistance mechanisms.Seventy-five 4 to >256 N. isolates 17 European countries during were examined using antimicrobial susceptibility testing WGS.Thirty-six multi-antigen sequence typing STs five phylogenomic clades, including 4-22 from several per clade, identified. The target mutation A2059G (Escherichia coli...
Abstract Objectives Novel antimicrobials for treatment of gonorrhoea are imperative. The first-in-class spiropyrimidinetrione zoliflodacin is promising and currently in an international Phase 3 randomized controlled clinical trial (RCT) uncomplicated gonorrhoea. We evaluated the vitro activity genetic conservation target (GyrB) other potential resistance determinants among 1209 consecutive Neisseria gonorrhoeae isolates obtained from 25 EU/European Economic Area (EEA) countries 2018 compared...
The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the Union/European Economic Area (EU/EEA). We present Euro-GASP results from 2019 (26 countries), linked patient epidemiological data, and compared with data previous years.Agar dilution minimum inhibitory concentration (MIC) gradient strip methodologies were used determine antimicrobial (using...
Abstract Background Imiquimod, a potent immunomodulator, not having direct antiproliferative activity, was found to be effective in genital and cutaneous premalignancies malignancies. As tumor development depends on blood vessel supply, the inhibition of angiogenesis could responsible for antitumor activity. Objective To find murine model whether imiquimod has antiangiogenic activity this is mediated by locally induced cytokines. Methods The study performed two cell lines: Skv human...
In Poland, gonorrhoea has been a mandatorily reported infection since 1948, however, the incidences are likely underestimated. No antimicrobial resistance (AMR) data for Neisseria gonorrhoeae internationally in nearly four decades, and concerning genetic characteristics of N. totally lacking. The aims this study were to investigate AMR previously currently recommended treatment options, main determinant (penA) extended-spectrum cephalosporins (ESCs), genotypic distribution isolates Poland...
Abstract Background Accurate molecular assays for prediction of antimicrobial resistance (AMR)/susceptibility in Neisseria gonorrhoeae (Ng) can offer individualized treatment gonorrhoea and enhanced AMR surveillance. Objectives We evaluated the new ResistancePlus® GC assay 23S 2611 (beta) (SpeeDx), resistance/susceptibility to ciprofloxacin azithromycin, respectively. Methods Nine hundred sixty-seven whole-genome-sequenced Ng isolates from 20 European countries, 143 Ng-positive (37 with...
The skin is the part of human body most vulnerable to ultraviolet (UV) radiation. spectrum negative effects UV radiation on ranges from acute erythema carcinogenesis. Between these extreme conditions, there are other common lesions, e.g., photoageing. aim this study was assess for signs photoageing in a group 52 men occupationally exposed natural There were 2 types examinations: an examination condition (moisture, elasticity, sebum, porosity, smoothness, discolourations and wrinkles) with...
Confidence in any diagnostic and antimicrobial susceptibility testing data is provided by appropriate regular quality assurance (QA) procedures. In Europe, the European Gonococcal Antimicrobial Susceptibility Programme (Euro-GASP) has been monitoring Neisseria gonorrhoeae since 2004. Euro-GASP includes an external assessment (EQA) scheme as essential component for a quality-assured laboratory-based surveillance programme. Participation EQA enables problems with performed to be identified...
One of two main mechanisms resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence TetM protein responsible for actively blocking tetracycline target site 30S ribosomal subunit. This mechanism encoded by conjugative plasmids. The second chromosomal nature and due to mutations specific genes.To determine incidence type tetM determinants TRNG strains isolated from patients presenting gonorrhea infection Dermatology Venereology Clinic Warsaw...