A5071820932- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Lanthanide and Transition Metal Complexes
- Cleft Lip and Palate Research
- Cerebrospinal fluid and hydrocephalus
- Craniofacial Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune Neurological Disorders and Treatments
- Tuberous Sclerosis Complex Research
- MRI in cancer diagnosis
- Long-Term Effects of COVID-19
- Head and Neck Surgical Oncology
- Peripheral Neuropathies and Disorders
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Electron Spin Resonance Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Diseases and Tuberculosis
- Sarcoidosis and Beryllium Toxicity Research
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Radiomics and Machine Learning in Medical Imaging
University of Oxford
2014-2024
Oxford University Hospitals NHS Trust
2015-2024
John Radcliffe Hospital
2010-2024
Oxford Health NHS Foundation Trust
2008-2023
National Health Service
2021
King's College London
2020
Imaging Center
2018
King's College Hospital
2017
Oxford BioMedica (United Kingdom)
2016
Wellcome Centre for Integrative Neuroimaging
2016
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
The original concept of the ischaemic penumbra suggested imaging regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation technique, has been used derive intracellular pH in preclinical stroke models proposed as metabolic marker penumbra. In this proof principle clinical study, we explored potential pH-weighted technique at tissue-level. Detailed...
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
Abstract Autoantibodies against the extracellular domain of N-methyl-d-aspartate receptor (NMDAR) NR1 subunit cause a severe and common form encephalitis. To better understand their generation, we aimed to characterize identify human germinal centres actively participating in NMDAR-specific autoimmunization by sampling patient blood, CSF, ovarian teratoma tissue and, directly from putative site CNS lymphatic drainage, cervical lymph nodes. From serum, both NR1-IgA NR1-IgM were detected more...
Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies. Frequent serum immunoglobulin Ms (IgMs) shifts in IgG subclasses were observed alongside preferential synthesis IgGs aquaporin-4–reactive B cells within nodes. Both intranodal antibodies robustly eliminated rituximab administration. This study systematically explores...
Rapid and accurate diagnosis of autoimmune encephalitis encourages prompt initiation immunotherapy toward improved patient outcomes. However, clinical features alone may not sufficiently narrow the differential diagnosis, awaiting autoantibody results can delay immunotherapy.
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation phenomenon that has potential for penumbra identification following stroke. The majority of literature thus far focused generating pH-weighted contrast using magnetization ratio asymmetry analysis instead quantitative mapping. In this study, widely used and model-based were both assessed APT data collected from healthy subjects (n = 2) hyperacute stroke patients 6, median time after onset 2...
BackgroundTranscranial ultrasound stimulation (TUS) holds promise as a novel technology for non-invasive neuromodulation, with greater spatial precision than other available methods and the ability to target deep brain structures. However, its safety efficacy behavioural electrophysiological modulation remains controversial it is not yet clear whether can be used manipulate neural mechanisms supporting higher cognitive function in humans. Moreover, concerns have been raised about potential...
Abstract Lymph node (LN) fine needle aspiration (LN FNA) represents a powerful technique for minimally invasive sampling of human LNs in vivo and has been used effectively to directly study aspects the germinal center response. However, systematic deep phenotyping cellular populations cell‐free proteins recovered by LN FNA not performed. Thus, we studied cervical FNAs as proof‐of‐concept single‐cell RNA‐sequencing proteomic analysis benchmark this compartment, define purity material,...
Amide proton transfer (APT) imaging may help identify the ischaemic penumbra in stroke patients, classical definition of which is a region tissue around core that hypoperfused and metabolically stressed. Given potential APT to complement existing techniques provide clinically-relevant information, there need develop analysis deliver robust repeatable metric. The challenge accurate quantification an metric has been heterogeneous in-vivo environment human tissue, exhibits several confounding...
Aim To investigate the interdependence between risk factors associated with long‐term intellectual development in individuals tuberous sclerosis complex ( TSC ). Method The Tuberous Sclerosis 2000 Study is a prospective longitudinal study of . In phase 1 study, baseline measures ability, epilepsy, cortical tuber load, and mutation were obtained for 125 children (63 females, 62 males; median age=39mo). 2, at an average 8 years later, abilities estimated 88 participants 35 unaffected siblings....
Limbic encephalitis associated with antibodies to components of the voltage-gated potassium channel complex (VGKCC-Ab-LE) often leads hippocampal atrophy and persistent memory impairment. Its long-term impact on regions beyond hippocampus, relationship between brain damage cognitive outcome, are poorly understood. We investigated nature structural functional abnormalities following VGKCC-Ab-LE its role in residual impairment.A cross-sectional group study was conducted. Twenty-four patients...
Vessel-selective dynamic angiograms provide a wealth of useful information about the anatomical and functional status arteries, including collateral flow blood supply to lesions. Conventional x-ray techniques are invasive carry some risks patient, so non-invasive alternatives desirable. Previously, non-contrast MRI based on arterial spin labeling (ASL) have been demonstrated using both spoiled gradient echo (SPGR) balanced steady-state free precession (bSSFP) readout modules, but no direct...
Perfusion-weighted imaging is used to select patients with acute ischemic stroke for intervention, but knowledge of cerebral perfusion can also inform the understanding injury. Arterial spin labeling allows repeated measurement absolute blood flow (CBF) without need exogenous contrast. The aim this study was explore relationship between dynamic CBF and tissue outcome in month after onset.Patients nonlacunar underwent ≤5 magnetic resonance scans at presentation, 2 hours, 1 day, week, month....
SARS-CoV-2 infection has been shown to damage multiple organs, including the brain. Multiorgan MRI can provide further insight on repercussions of COVID-19 organ health but requires a balance between richness and quality data acquisition total scan duration. We adapted UK Biobank brain protocol produce high-quality images while being suitable as part post-COVID-19 multiorgan exam. The analysis pipeline, also from Biobank, includes new imaging-derived phenotypes (IDPs) designed assess...
Abstract Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather than measuring directly. In this study we utilize a non-invasive, non-contrast magnetic resonance imaging (MRI)-based method to directly quantify stroke patients. Vessel-encoded multi-postlabeling delay arterial spin labeling (ASL) was used separately the blood flow...
The squamosal suture is one of the lateral minor skull sutures, separating parietal and squamous temporal bones. While phenotypic appearances sequelae synostosis major cranial vault sutures are well documented, little reported concerning (SQS). aim this study was to determine frequency synostosis, document significance entity.A retrospective review diagnostic imaging for all new pediatric patients (aged ≤16 years) referred Oxford Craniofacial Unit between January 2008 February 2013 completed...