A5100367899- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Transcranial Magnetic Stimulation Studies
- Advanced Fiber Laser Technologies
- Plant Molecular Biology Research
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Plant biochemistry and biosynthesis
- Neurogenetic and Muscular Disorders Research
- Laser-Matter Interactions and Applications
- Helicobacter pylori-related gastroenterology studies
- Catalysts for Methane Reforming
- RNA Research and Splicing
- Plant-Microbe Interactions and Immunity
- Thermochemical Biomass Conversion Processes
- Solid State Laser Technologies
- Plant tissue culture and regeneration
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
China Agricultural University
2024-2025
Zhengzhou University
2022-2025
Zhengzhou Children's Hospital
2022-2025
Shanghai Mental Health Center
2016-2025
Shanghai Jiao Tong University
2016-2025
Xinjiang Agricultural University
2024-2025
Fudan University
2022-2024
Jiangsu University
2022-2024
University College London
2020-2024
National Hospital for Neurology and Neurosurgery
2020-2024
Abstract Immune checkpoint blockade therapies targeting the PD-L1/PD-1 axis have demonstrated clear clinical benefits. Improved understanding of underlying regulatory mechanisms might contribute new insights into immunotherapy. Here, we identify transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) as a modulator PD-L1 post-translational modifications in tumor cells. Mechanistically, TMUB1 competes with HECT, UBA WWE (HUWE1), E3 ubiquitin ligase, to interact inhibit its...
Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis, and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first proangiogenic molecule discovered, it facilitates angiogenesis by activating FGF receptor 1 (FGFR1) signaling in endothelial cells. However, precise roles of FGFR FGF/FGFR axis remain unclear, especially because contradictory phenotypes vivo gene deficiency models. Our previous study results suggested a potential role...
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD. The most common genetic cause of ALS/FTD is expansion the intronic hexanucleotide repeat (GGGGCC) n in C9orf72 . Here, we investigate formation nucleic acid secondary structures these repeats, their role generating condensates characteristic We observe significant aggregation sequence , which associate to...
BACKGROUND: Angiogenesis, which plays a critical role in embryonic development and tissue repair, is controlled by set of angiogenic signaling pathways. As TF (transcription factor) belonging to the basic helix-loop-helix family, HEY (hairy/enhancer split related with YRPW motif)-1 (YRPW motif, abbreviation 4 highly conserved amino acids motif) has been identified as key player developmental angiogenesis. However, precise mechanisms underlying HEY1’s actions angiogenesis remain largely...
Background/Aims: Despite strong association between obesity and the pathogenesis of type 2 diabetes (T2D), only a subset obese individuals eventually develops T2D. We sought to determine immunological factors behind this heterogeneity. Methods: Peripheral blood non-diabetic subjects diabetic were collected B cell responses in these analyzed. Results: found that cells from had similar subtype composition secreted levels low-grade pro-inflammatory cytokines subjects, characteristic background...
Posttranslational modifications (PTMs) are the lingua franca of cellular communication. Most PTMs enzyme-orchestrated. However, reemergence electrophilic drugs has ushered mining unconventional/non-enzyme-catalyzed electrophile-signaling pathways. Despite latest impetus toward harnessing kinetically and functionally privileged cysteines for drug design, identifying these sensors remains challenging. Herein, we designed "G-REX"—a technique that allows controlled release reactive electrophiles...
Abstract Background With the improvement of bacterial detection, theory sterile female upper reproductive tract has been frequently challenged in recent years. However, thus far, no researchers have used ovaries as study targets. Methods Six women who were diagnosed with ovarian cancer included group, and ten a noncancerous condition (including three patients uterine myoma seven adenomyosis) control group. Immunohistochemistry staining using an antibacterial lipopolysaccharide (LPS) antibody...
Hypoxia is a major cause and promoter of pulmonary hypertension (PH), representative vascular remodeling disease with poor prognosis high mortality. However, the mechanism underlying how arterial system responds to hypoxic stress during PH remains unclear. Endothelial mitochondria are considered signaling organelles on oxygen tension. Results from previous clinical research our studies suggested potential role posttranslational SUMOylation (small ubiquitin-like modifier modification) in...
Amyotrophic lateral sclerosis (ALS) is characterized by nucleocytoplasmic mislocalization of the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more widespread mRNA and mislocalization. Here, we employed fractionation, RNA sequencing, mass spectrometry to investigate localization in induced pluripotent stem cell-derived motor neurons (iPSMNs) from ALS patients with TARDBP VCP mutations. mutant iPSMNs exhibited extensive redistribution, RBP mislocalization, splicing...
Abstract Corneal neovascularization (CNV) is a common clinical finding seen in range of eye diseases. Current therapeutic approaches to treat corneal angiogenesis, which vascular endothelial growth factor (VEGF) A plays central role, can cause variety adverse side effects. The technology Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 edit VEGFA gene suppress its expression. CRISPR offers novel opportunity CNV. This study shows that depletion with CRISPR/Cas9 system...
Abstract Background Powdery mildew, caused by Eeysiphe heraclei , seriously threatens Heracleum moellendorffii Hance. Plant secondary metabolites are essential to many activities and necessary for defense against biotic stress. In order clarify the functions of these in response pathogen, our work concentrated on variations accumulation H. during E. infection. Results Following infection, a significant upregulation coumarin metabolites—particularly simple coumarins associated genes was...
Abstract Although C2H2 zinc finger transcription factors are important in plant growth, development, and stress resistance, their specific roles fruit ripening have been less explored. Here, we demonstrate that the factor 5 (SlZAT5) regulates tomato (Solanum lycopersicum L.). Overexpression of SlZAT5 delayed ripening, while its knockout accelerated it, confirming role as a negative regulator. functions transcriptional repressor by directly inhibiting ripening-related genes, including SlACS4,...
Non-coding RNAs (ncRNAs) serve as crucial regulatory elements in the process of adipogenesis animals; however, specific roles and interrelationships ncRNAs bovine fat deposition remain poorly understood. This study aims to investigate differentially expressed longissimus dorsi muscle Xinjiang Brown cattle (XB) Angus $$\times$$ Wagyu (AW), elucidate mechanisms underlying lipidogenesis that may involve ncRNAs. Four four were selected, ensuring they are subjected identical feeding conditions,...