A5025653081- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Per- and polyfluoroalkyl substances research
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Geology and Paleoclimatology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Lipids, and Metabolism
- GDF15 and Related Biomarkers
- Gestational Diabetes Research and Management
- Heat shock proteins research
- Bioinformatics and Genomic Networks
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- Heme Oxygenase-1 and Carbon Monoxide
- Seismic Waves and Analysis
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
Shanghai Jiao Tong University
2023-2025
Guangdong Medical College
2024-2025
Ministry of Ecology and Environment
2021-2024
Dongguan People’s Hospital
2024
Huazhong University of Science and Technology
2021-2024
Hainan University
2024
Tianjin University
2023-2024
First Hospital of Shijiazhuang
2019
Small extracellular vesicles (sEVs) derived from M2 microglia (M2-microglia-derived small [M2-sEVs]) contribute to central nervous system repair, although the underlying mechanism remains unknown. In this study, we aimed identify through which microRNA-124 (miR-124) carried in sEVs promotes neural stem cell (NSC) proliferation and neuronal differentiation ischemic mouse brain.M2-sEVs with or without miR-124 knockdown were injected intravenously for 7 consecutive days after transient middle...
Neuroendocrine prostate cancer (NEPC) typically implies severe lethality and limited treatment options.The precise identification of NEPC cells holds paramount significance for both research clinical applications, yet valid biomarker remains to be defined.Methods: Leveraging 11 published NE-related gene sets, single-cell RNA-sequencing (scRNA-seq) cohorts, 15 bulk transcriptomic 13 experimental models (PCa), we employed multiple advanced algorithms construct validate a robust risk prediction...
Abstract Stress in the endoplasmic reticulum (ER) may perturb proteostasis and activates unfolded protein response (UPR). UPR activation is frequently observed cancer cells believed to fuel progression. Here, we report that one of three sensors, ATF6α, was associated with prostate (PCa) development, while both genetic pharmacological inhibition ATF6α impaired survival castration‐resistance PCa (CRPC) cells. Transcriptomic analyses identified molecular pathways deregulated upon depletion,...
Highlights•MBP exposure promotes NSC differentiation into astrocytes and astrocyte reactivity•MBP impairs cognitive function by increasing astrocyte-induced synapse phagocytosis•MBP affects reactivity through IRE1α/XBP1s pathwaySummaryHumans are widely exposed to phthalates, a common chemical plasticizer. Previous cohort studies have revealed that maternal monobutyl phthalate (MBP), key metabolite of is associated with neurodevelopmental defects. However, the molecular mechanism remains...
Abstract Extracellular vesicles (EVs) have shown great potential for treating various diseases. Translating EVs‐based therapy from bench to bedside remains challenging due inefficient delivery of EVs the injured area and lack techniques visualize entire targeting process. Here we developed a dopamine surface functionalization platform that facilitates easy simultaneous conjugation peptide multi‐mode imaging probes EVs. Utilizing this concurrently modified M2 microglia‐derived (M2‐EVs) with...
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies with complex phenotypic, etiological, biological, clinical heterogeneities. Previous studies have proposed different clinically relevant subtypes HNSCC, but little known about its corresponding prognosis or suitable treatment strategy. Here, we identified 101 core genes from three prognostic pathways, including mTORC1 signaling, unfold protein response, UV response UP, in 124 pairs tumor matched normal...
Abstract Benzophenones are widely supplemented in personal care products, but little is known about its neurodevelopmental toxicity. The previous epidemiological study discovered a negative correlation between maternal exposure to benzophenone metabolite 4‐hydroxybenzophenone (4HBP) and child's neurodevelopment, yet the causal relationship detailed mechanism remain be defined. Here, it reported that prenatal, not postnatal, environmentally relevant level of 4HBP impairs hippocampus...
Recent investigations have revealed that oxidative stress can lead to neuronal damage and disrupt mitochondrial endoplasmic reticulum functions after intracerebral hemorrhage (ICH). However, there is limited evidence elucidating their role in maintaining homeostasis. Metabolomics analysis, RNA sequencing, CUT&Tag-seq were performed investigate the mechanism underlying interaction between PERK/ATF4 branch of (ERS) one-carbon (1C) metabolism during resistance stress. The association 1C ERS ICH...
Per- and polyfluoroalkyl substances (PFASs) are common environmental contaminants widely detected in humans. Previous studies have linked PFASs exposure to adverse birth outcomes. However, the association between maternal hemoglobin (Hb) hematocrit (HCT) remains unclear. We aimed explore relationship with Hb HCT during pregnancy. The present cohort study included 1044 pregnant women from Wuhan, China. Maternal were measured first, second third trimesters, 13 cord sera. Mixed linear models...
The 2021 Mw 7.4 Maduo (Madoi) earthquake that struck the northern Tibetan Plateau resulted in widespread coseismic deformation features, such as surface ruptures and soil liquefaction. By utilizing unmanned aerial vehicle (UAV) photogrammetry technology, we accurately recognize map 39,286 liquefaction sites within a 1.5 km wide zone along rupture. We then systematically analyze distribution characteristics possible influencing factors. density remains on higher level 250 m from rupture...
Abstract The reconstruction of paleo‐elevation serves a dual purpose to enhance our comprehension geodynamic processes affecting terrestrial landforms and contribute significantly the interpretation atmospheric circulation biodiversity. oxygen ( δ 18 O w ) deuterium D isotopes in precipitation are systematically depleted with increase altitude, which typical widely applicated paleo‐altimeters. utilization hydrogen isotope hydrous silicate minerals within shear zone system, volcanic glass,...
ABSTRACT Neural stem cells (NSCs) are essential for brain development due to their ability proliferate and differentiate into various neural cell types. Neonicotinoid insecticides (NNIs), which have replaced traditional pesticides, now widely used frequently detected in environmental biological samples. Prenatal exposure NNIs has been associated with an increased risk of neurodevelopmental disorders offspring, yet the causal relationship underpinning mechanism remain be clarified. As one...
BackgroundPer- and polyfluoroalkyl substances (PFASs) are common environmental contaminants widely detected in humans. Previous studies have linked PFASs exposure to adverse birth outcomes. However, the association between pregnancy blood viscosity indexes, including hemoglobin (Hb) hematocrit (HCT), remains unclear.ObjectivesWe aimed explore relationship with indexes during pregnancy.MethodsThe present cohort study included 1044 pregnant women from Wuhan. Maternal HCT Hb were measured...
Stress in the endoplasmic reticulum (ER) may perturb proteostasis and activates unfolded protein response (UPR). UPR activation is frequently observed cancer cells, believed to fuel progression. Here, we report that one of three sensors, ATF6α, was associated with prostate (PCa) development, while both genetic pharmacological inhibition ATF6α impaired survival castration-resistance PCa (CRPC) cells. Transcriptomic analyses identified molecular pathways deregulated upon depletion, also...
Maternal Benzophenone Exposure In article number 2102686 by Shunqing Xu, Yaohui Tang, Xia Sheng, and co-workers, it is reported that maternal exposure to benzophenone its major metabolite 4-hydroxybenzophenone during pregnancy causes endoplasmic reticulum proteotoxicity neuroinflammation, which lead cognitive dysfunction neurodevelopmental toxicity in offspring mice. This alerts the excessive use of personal care products may impair child's neurodevelopment.