A5016451976- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Extracellular vesicles in disease
- Barrier Structure and Function Studies
- MicroRNA in disease regulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
Shanghai Jiao Tong University
2023-2025
Ruijin Hospital
2024
Abstract Extracellular vesicles (EVs) have shown great potential for treating various diseases. Translating EVs‐based therapy from bench to bedside remains challenging due inefficient delivery of EVs the injured area and lack techniques visualize entire targeting process. Here we developed a dopamine surface functionalization platform that facilitates easy simultaneous conjugation peptide multi‐mode imaging probes EVs. Utilizing this concurrently modified M2 microglia‐derived (M2‐EVs) with...
Abstract Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts microenvironment (TIME) remains unknown. In this study we explored 1) immunomodulatory role secretable human DR4/5 ligand, necrosis factor (TNF)-related apoptosis-inducing ligand (S-TRAIL); 2) potential allogeneic...