A5017489626- Virus-based gene therapy research
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Gastrointestinal Tumor Research and Treatment
- HER2/EGFR in Cancer Research
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Metastasis and carcinoma case studies
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer Diagnosis and Treatment
- Immune cells in cancer
Okayama University
2011-2025
Brigham and Women's Hospital
2020-2025
Harvard University
2021-2025
Okayama University Hospital
2025
Okayama Shoka University
2025
Iwakuni Medical Center
2012-2024
Harvard Stem Cell Institute
2021
Ministry of Education, Culture, Sports, Science and Technology
2017
Ministry of Health Labour and Welfare
2017
Creative Research Enterprises (United States)
2016
The clinical benefit of monotherapy involving immune checkpoint inhibitors (ICIs) such as anti-programmed death-1 antibody (PD-1 Ab) is limited to small populations. We previously developed a telomerase-specific oncolytic adenovirus, Telomelysin (OBP-301), the safety which was confirmed in phase I study. Here, we examined potential OBP-502, an OBP-301 variant, agent for inducing immunogenic cell death (ICD) and synergistically enhancing efficacy OBP-502 with PD-1 Ab using CT26 murine colon...
Abstract While the importance of programmed death-ligand 1 (PD-L1), mutation burden caused by microsatellite instability (MSI), and CD8+ tumor infiltrating lymphocytes (TILs) has become evident, significance PD-L1 expression on prognosis still remains controversial. We evaluated usefulness combined markers MSI or TILs as a prognostic biomarker in gastric cancer. A total 283 patients with cancer were reviewed retrospectively. >5% cells was defined PD-L1-positive. PD-L1-positive rate 15.5%...
Abstract Background Pancreatic cancer is an aggressive, immunologically “cold” tumor. Oncolytic virotherapy a promising treatment to overcome this problem. We developed telomerase-specific oncolytic adenovirus armed with p53 gene (OBP-702). Methods investigated the efficacy of OBP-702 for pancreatic cancer, focusing on its long-term effects via long-lived memory CD8 + T cells including tissue-resident (TRMs) and effector (TEMs) differentiated from precursor (TEMps). Results First, in vitro,...
Oncolytic virotherapy has the disadvantage of being unsuitable for systemic delivery due to immune elimination. Liposomal encapsulation is well-recognized reduce elimination and enhance stability drugs in bloodstream. In present study, potential liposome-encapsulated plasmid DNA telomerase-specific oncolytic adenovirus (TelomeScan) expressing GFP (Lipo-pTS) as an adenoviral agent suitable was investigated. Lipo-pTS, which a diameter 40-50 nm, showed potent antitumor effects on HCT116 colon...
Extracellular vesicles (EVs) play important roles in various intercellular communication processes. The abscopal effect is an interesting phenomenon cancer treatment, which immune activation generally considered a main factor. We previously developed telomerase-specific oncolytic adenovirus, Telomelysin (OBP-301), and occasionally observed therapeutic effects on distal tumors after local treatment immunodeficient mice. In this study, we hypothesized that EVs may be involved the of OBP-301....
Trifluridine/tipiracil (FTD/TPI) is one of the options for late-line treatment colorectal cancer (CRC). However, specific patient populations that would particularly benefit from it remain unclear. This study attempted to identify predictive markers chemotherapy efficacy with trifluridine/tipiracil (FTD/TPI), focusing on RNA-editing enzyme adenosine deaminase acting RNA 1 (ADAR1) expression and neutrophil–lymphocyte ratio (NLR). To assess effectiveness FTD/TPI in CRC patients, we...
Abstract Background Immune-checkpoint inhibitors have shown clinical benefit in non-small cell lung cancer (NSCLC) derived brain metastasis (BM), however, their efficacy to leptomeningeal (LLBM) remains poor. Methods A paired matched RNA expression dataset of patients with NSCLCs and BMs was analyzed idenfiy BM specific suppressive tumor microenvironment (TME) features. Next, we created immune-competent LLBM mouse models that mimic LLBM. We evaluated the intrathecal (IT) delivery allogeneic...
Abstract Butyrate, a short-chain fatty acid (SCFA) produced by gut bacteria in the colon, serves as critical energy source for colonocytes. Gut microbiota and its primary metabolite, butyrate, have been reported to potentially modulate tumor sensitivity chemotherapy or immunotherapy, although underlying mechanisms remain unclear. Oncolytic virotherapy is promising antitumor treatment that selectively induces oncolytic cell death cells. Previously, we developed OBP-702, telomerase-specific...
Abstract Background: Chemotherapy resistance is a major contributor of the poor prognosis pancreatic cancer, yet its underlying mechanisms remain poorly understood. Neutrophil Extracellular Traps (NETs), form neutrophil-specific cell death, have been reported to be associated with in various cancers because they act suppress tumor immunity and promote metastasis. Recently, chemotherapy-stimulated NETs, termed “ChemoNETosis”, were contribute chemotherapy breast cancer (Mousset A, Cancer cell....
Abstract Oncolytic viral (OV) therapy is a promising approach for treating metastatic cancer; however, systemic delivery remains significant challenge due to antiviral immune responses. We previously developed telomerase-specific OV, Telomelysin (OBP-301), which utilizes the hTERT promoter drive expression of E1A and E1B. OBP-301 demonstrated an abscopal effect when combined with anti-PD-1 antibodies in distant metastases vivo murine colorectal cancer (MC38) mouse models. A p53-armed...
Abstract Background: Regarding the sidedness of colorectal cancer, right-sided cancer (RCRC) and left-sided (LCRC) originate from midgut hindgut, respectively. It is known that in stages III IV, RCRC has a poorer prognosis compared to LCRC. Furthermore, liver metastasis (CRLM) also varies depending on primary tumor's sidedness. Although differences such as MSI-H status, BRAF mutations, histological types have been noted between right- cancers, clinical observations recognized treatment...
Abstract Background: In recent years, the importance of perioperative treatment in cancer therapy has increased, and postoperative adjuvant therapies using immune checkpoint inhibitors (ICIs) have been applied clinically multiple types. However, efficacy ICIs as monotherapy is often limited. We developed a telomerase-specific oncolytic virus (OV), OBP-301, its p53 gene-armed derivative, OBP-702. OBP-301 currently undergoing clinical trials. Previous studies demonstrated enhanced antitumor...
Background: Robotic gastrectomy (RG) has emerged as a promising approach for gastric cancer (GC) treatment, offering advantages such enhanced dexterity, improved visualization, and increased precision. However, its widespread adoption remains limited due to technical complexity, high costs, applications, insufficient evidence. Methods: We conducted single-center, prospective study evaluate the safety feasibility of RG, including robotic total (RTG), proximal (RPG), distal (RDG) with D1+ or...
Postoperative local recurrence remains an important issue in rectal cancer, and the optimal treatment strategy, surgical approach, prognosis after are yet to be addressed. We reviewed 21 patients who underwent resection at our department for postoperative pelvic of cancer between January 2013 December 2022, performed a retrospective analysis outcomes terms preoperative approach. Of patients, four (19%) were treated with upfront surgery (Upfront group), 13 (62%) chemotherapy (Chemotherapy...
The aging population challenges surgical management of rectal cancer. This study evaluated the short-term safety robot-assisted surgery (RARS) in patients aged 75 years and older, examining perioperative complications outcomes this vulnerable population. A single-center retrospective cohort was conducted at Okayama University Hospital from September 2020 to December 2024, including 109 undergoing RARS. Patients were divided into older (≥75 years, n=19) non-older (<75 n=90) groups. Surgical...
ABSTRACT Background Anterior cutaneous nerve entrapment syndrome (ACNES) is often overlooked as a cause of chronic abdominal pain. Trigger point injections (TPIs) serve both diagnostic and therapeutic tool. Although neurectomy frequently chosen for patients with severe ACNES, its surgical outcomes remain unclear. Aim This study aims to evaluate the short‐ long‐term propose novel algorithm. Methods A cohort postoperative presenting ACNES between 2016 2023 was retrospectively evaluated....
Abstract Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts microenvironment (TIME) remains unknown. In this study we explored 1) immunomodulatory role secretable human DR4/5 ligand, necrosis factor (TNF)-related apoptosis-inducing ligand (S-TRAIL); 2) potential allogeneic...
Oncolytic virus therapy has shown activity against primary melanomas; however, its efficacy in brain metastases remains challenging, mainly because of the delivery and immunosuppressive nature tumors brain. To address this challenge, we first established PTEN-deficient melanoma metastasis mouse models characterized them to be more compared with melanoma, mimicking clinical settings. Next, developed an allogeneic twin stem cell (TSC) system composed two tumor-targeting (SC) populations. One...