A5026217835- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Oral microbiology and periodontitis research
- Diverticular Disease and Complications
- Sarcoma Diagnosis and Treatment
- Ureteral procedures and complications
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- RNA regulation and disease
- Bladder and Urothelial Cancer Treatments
- Streptococcal Infections and Treatments
- Anorectal Disease Treatments and Outcomes
- Cancer Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Bacterial Identification and Susceptibility Testing
- Nutrition and Health in Aging
- Tumors and Oncological Cases
- Neuroendocrine Tumor Research Advances
- dental development and anomalies
Okayama University
2013-2025
Okayama University Hospital
2024-2025
Kansai Medical University
2020-2025
University of Dental Medicine
2021
Trifluridine/tipiracil (FTD/TPI) is one of the options for late-line treatment colorectal cancer (CRC). However, specific patient populations that would particularly benefit from it remain unclear. This study attempted to identify predictive markers chemotherapy efficacy with trifluridine/tipiracil (FTD/TPI), focusing on RNA-editing enzyme adenosine deaminase acting RNA 1 (ADAR1) expression and neutrophil–lymphocyte ratio (NLR). To assess effectiveness FTD/TPI in CRC patients, we...
Abstract Background: Colorectal cancer (CRC) is one of the most prevalent cancers. In case CRC with distant metastasis, it initially treated by chemotherapy, and oxaliplatin often used in first-line regimen. However, chemoresistance becomes an issue remains unclear. We previously reported that RNA editing enzyme ADAR1 causes stemness (JCI Insight, 2018) induces poor prognosis liver metastasis (Scientific Reports, 2023). this study, we cleared role CRC. Methods: performed immunohistochemistry...
Postoperative local recurrence remains an important issue in rectal cancer, and the optimal treatment strategy, surgical approach, prognosis after are yet to be addressed. We reviewed 21 patients who underwent resection at our department for postoperative pelvic of cancer between January 2013 December 2022, performed a retrospective analysis outcomes terms preoperative approach. Of patients, four (19%) were treated with upfront surgery (Upfront group), 13 (62%) chemotherapy (Chemotherapy...
The aging population challenges surgical management of rectal cancer. This study evaluated the short-term safety robot-assisted surgery (RARS) in patients aged 75 years and older, examining perioperative complications outcomes this vulnerable population. A single-center retrospective cohort was conducted at Okayama University Hospital from September 2020 to December 2024, including 109 undergoing RARS. Patients were divided into older (≥75 years, n=19) non-older (<75 n=90) groups. Surgical...
This study aims to examine why we encounter a pathological circumferential resection margin (pCRM)-positive specimen whose preoperative MRI indicates negative mesorectal fascia involvement in middle low rectal cancer. Forty-four consecutive patients included this had c(yc)T1–3 primary adenocarcinoma without and underwent laparoscopic total excision (TME) with curative intent the Department of Gastrointestinal Surgery Kansai Medical University Hospital from January 2014 April 2018. We adopted...
Colorectal cancer (CRC) is considered the third most common type of worldwide. Tumor-associated macrophages (TAMs) have been shown to promote drug resistance. Adenosine-to-inosine RNA-editing, as regulated by adenosine deaminase acting on RNA (ADAR), a process that induces posttranscriptional modification critical oncogenes. The aim this study determine whether signals from cells would induce RNA-editing in macrophages. effects phenotypes were analyzed using clinical samples and vitro vivo...
Glucan-binding proteins (Gbps) of Streptococcus mutans, a major pathogen dental caries, mediate the binding glucans synthesized from sucrose by action glucosyltransferases (GTFs) encoded gtfB, gtfC, and gtfD. Several stress proteins, including DnaK GroEL dnaK groEL, are related to environmental tolerance. The contribution Gbp expression biofilm formation was analyzed focusing on levels genes encoding GTFs proteins. Biofilm-forming assays were performed using GbpA-, GbpB-, GbpC-deficient...
BRAF-mutant microsatellite-stable colorectal cancer (CRC), metastasized to distant sites, is associated with a poor prognosis. However, the BEACON CRC regimen, comprising BRAF inhibitor, MEK and anti-EGFR antibody, offered prolonged Nonetheless, resistance this regimen may occur, as observed in our reported case of CRC, where KRAS mutation was identified addition V600E mutation. Here, we present 74-year-old woman rectal (pT4bN1bM0 Stage IIIc) harboring After resection primary tumor during...
Tailgut cyst is a rare cystic disease of the anterior sacral surface and remains an embryonic tail gut. cysts have potential for malignancy, complete resection with adequate surgical margin necessary. Even if incomplete does not result in recurrence malignant disease, there risk local infection leading to refractory fistulas. The optimal treatment such recurrent lesions has been reported. We describe case which combination laparoscopic transsacral approaches was effective resecting fistula...
Magnetic hyperthermia (MHT), which combines magnetic nanoparticles (MNPs) with an alternating field (AMF), holds promise as a cancer therapy. There have been many studies about hyperthermia, most of performed by direct injection MNPs into tumor tissues. However, there no reports treating peritoneal disseminated disease MHT to date. In the present study, we treated metastasis gastric using superparamagnetic iron oxide (Fe3O4) nanoparticle (SPION) coated carboxydextran MNP, in orthotopic mouse...
Streptococcus mutans produces 3 types of glucosyltransferases (GTFs), whose cooperative action is essential for cellular adhesion. The recombinase A (RecA) protein required homologous recombination. In our previous study, we isolated several strains with a smooth colony morphology and low GTF activity, characteristics speculated to be derived from the fusions. purpose present study was investigate mechanism those S. strain MT8148 grown in presence recombinant RecA (rRecA) protein, after...
Hyperthermia has been used for cancer therapy a long period of time, but shown limited clinical efficacy. Induction-heating hyperthermia using the combination magnetic nanoparticles (MNPs) and an alternating field (AMF), termed (MHT), previously efficacy in orthotopic mouse model disseminated gastric cancer. In present study, superparamagnetic iron oxide (SPIONs), type MNP, were conjugated with anti-HER2 antibody, trastuzumab anti-HER2-antibody-linked SPION (anti-HER2 SPIONs). Anti-HER2...
Mouth rinses are a useful supplementary tool for the prevention of oral infectious diseases. Although antimicrobial effects mouth have been investigated, there few studies focusing on comparison among various bacterial species. In present study, inhibitory effect commercial rinse, "ConCoolF," and each its major components, chlorhexidine gluconate, ethanol, green tea extract, multiple species bacteria were investigated. Inhibition growth was observed in all cariogenic streptococcal with...
Ureteral injury during pelvic surgery is a serious complication that requires special attention. The fluorescent ureteral catheter near-infrared ray sets are 6.0F catheters containing substances along their length can be recognized by laparoscopic indocyanine green camera. We present our experience using in 6 consecutive patients who underwent for recurrent tumors.The were inserted into the bilateral ureters all patients, with exception of patient 5 (left unilateral), urologists cystoscope...
Rectal gastrointestinal stromal tumors (GISTs) are often asymptomatic and may be detected as giant tumors. This require highly invasive surgery for radical resection. Here, we describe a 74-year-old man with locally advanced non-metastatic GIST in the right anterolateral wall of lower rectum. The tumor was (128 × 93 mm), invasion into adjacent organs (right seminal vesicle prostate gland) suspected. Although neoadjuvant chemotherapy (NAC) imatinib reduced size, it still giant, 80 mm...
Several image navigation techniques can recognize the route of urinary tract, but such have not been widely accepted because they require special equipment or specific adjustment an indocyanine green reagent.1–3 Fluorescent ureteral catheter NIRC (Near Infrared Ray Catheter) sets are 6.0F catheters that allow continuous flow from renal calyces to external collection bag. Such contain fluorescent substances along their length be recognized by laparoscopic cameras, which available several...
We report two resected cases of solitary fibrous tumors (SFT) that were accidentally found in the pelvic cavity. Case 1 was a 54-year-old male. A colonoscopy for examination intestinal polyps revealed an extramural tumor right anterior wall low rectum. preoperative MRI showed well-demarcated T1 and T2 mixed intensity (53 × 36 mm) located lateral to rectum behind seminal vesicle. Laparoscopic surgery successful extirpation. Immunohistochemical specimen STAT6 (+) CD34 cells, Ki67 positivity...
Abstract Aim This study aimed to evaluate the relationship between p62 expression status and tumour regression grade in advanced rectal cancer. Methods We enrolled 47 consecutive patients with cancer who underwent chemoradiation therapy (CRT) before surgery. biopsy specimens was immunohistochemically evaluated, score (staining intensity × positive cells, %) calculated (range 0–300). The CRT effect analysed. Results staining +2 +3 29 18 patients, respectively. median proportion of neoplastic...
Post-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) survival the patient undergoing gastrectomy. We have introduced perioperative post-discharge continuous nutritional counseling (CNC) to prevent BWL improve QOL after In present study, we evaluated effect CNC on using Syndrome Assessment Scale-45 (PGSAS-45). Eighty-three patients with gastric cancer (GC) who underwent curative gastrectomy between March 2018 July 2019 were retrospectively analyzed....