A5077863716- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cervical and Thoracic Myelopathy
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Urticaria and Related Conditions
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Vasculitis and related conditions
- Intestinal and Peritoneal Adhesions
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nonmelanoma Skin Cancer Studies
- Allergic Rhinitis and Sensitization
- Hernia repair and management
- Metastasis and carcinoma case studies
- Bone Tumor Diagnosis and Treatments
Okayama University
2022-2025
Okayama Shoka University
2025
Okayama University Hospital
2024
Fukuyama City Hospital
2020-2024
Himeji Red Cross Hospital
2018
Abstract Butyrate, a short-chain fatty acid (SCFA) produced by gut bacteria in the colon, serves as critical energy source for colonocytes. Gut microbiota and its primary metabolite, butyrate, have been reported to potentially modulate tumor sensitivity chemotherapy or immunotherapy, although underlying mechanisms remain unclear. Oncolytic virotherapy is promising antitumor treatment that selectively induces oncolytic cell death cells. Previously, we developed OBP-702, telomerase-specific...
Abstract Oncolytic viral (OV) therapy is a promising approach for treating metastatic cancer; however, systemic delivery remains significant challenge due to antiviral immune responses. We previously developed telomerase-specific OV, Telomelysin (OBP-301), which utilizes the hTERT promoter drive expression of E1A and E1B. OBP-301 demonstrated an abscopal effect when combined with anti-PD-1 antibodies in distant metastases vivo murine colorectal cancer (MC38) mouse models. A p53-armed...
Abstract Background: In recent years, the importance of perioperative treatment in cancer therapy has increased, and postoperative adjuvant therapies using immune checkpoint inhibitors (ICIs) have been applied clinically multiple types. However, efficacy ICIs as monotherapy is often limited. We developed a telomerase-specific oncolytic virus (OV), OBP-301, its p53 gene-armed derivative, OBP-702. OBP-301 currently undergoing clinical trials. Previous studies demonstrated enhanced antitumor...
Advanced neuroendocrine carcinoma (NEC) has an extremely poor prognosis, partly explained by the rarity and diagnostic difficulty, for which most appropriate treatment strategy not been established. In this report, we discuss a case of unresectable advanced esophagogastric junction NEC, was difficult to diagnose, that achieved relatively long-term survival with multidisciplinary centered on nivolumab. A man in his 60s initially diagnosed squamous cell (SCC). The lymph node metastasis...
Abstract Background A majority of gastrinomas causing Zollinger–Ellison syndrome are located in the duodenum or pancreas. Primary hepatic rare and difficult to diagnose. We report a case primary gastrinoma, which could be diagnosed preoperatively. Case presentation 29-year-old man with 55-mm tumor segments 5 6 (S 5/6) liver was admitted our hospital. After thorough investigations, he treated for suspected inflammatory pseudotumor advised undergo routine follow-up. Two years later, revisited...
Post-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) survival the patient undergoing gastrectomy. We have introduced perioperative post-discharge continuous nutritional counseling (CNC) to prevent BWL improve QOL after In present study, we evaluated effect CNC on using Syndrome Assessment Scale-45 (PGSAS-45). Eighty-three patients with gastric cancer (GC) who underwent curative gastrectomy between March 2018 July 2019 were retrospectively analyzed....
Abstract Background Laparoscopic anatomic liver resection is technically demanding, given the need to safely isolate Glissonean pedicles and expose hepatic veins (HVs) on parenchyma cut surface. Laennec’s capsule observed around root of HVs. However, its existence, particularly peripheral side HVs, remains controversial. Herein, we describe capsule-related histopathological findings HVs a safe laparoscopic left medial sectionectomy utilizing capsule. Methods The extrahepatic approach was...
症例は64歳の男性で,上部内視鏡検査で胃体上部小彎前壁に主座を持ち,食道胃接合部まで浸潤する3型腫瘍を認めた.腹部造影CTとPET-CTで胃噴門~体部小彎にかけて漿膜浸潤を疑う原発巣を認め,S5,S7に多発肝転移と,腹腔動脈根部から大動脈分岐部付近まで及ぶ傍大動脈リンパ節転移を認めた.生検検体による病理組織学的検査でHER2 scoreは3+であり,capecitabine+cisplatin+trastuzumab(初回~術前8 mg/kg)療法を開始した.8コース目以降はcisplatin抜きで計25コース終了後,肝転移巣とリンパ節転移巣の著明な縮小を確認し,脾摘と大網切除を伴う開腹胃全摘,D2を施行した.病理組織学的検査では,pT2,N0,ly1,v0,pStage IBであった.術後trastuzumab単独投与(6 mg/kg)を1か月毎に26コース継続し,初診時から7年半経過した現在,無再発生存中である.多発肝転移と傍大動脈リンパ節転移を伴う切除不能HER2陽性胃癌に対し集学的治療で長期生存した1例を経験したので報告する.
Navigation surgery using indocyanine green (ICG) fluorescence imaging has been used in thoracoabdominal surgery, and its usefulness reported many cases. In this study, laparoscopic lateral lymph node dissection was performed ICG a patient with left femoral spinous cell carcinoma inguinal external iliac metastases. Spinous is classified as rare cancer Japan, there scarcity of evidence for pelvic dissection, well lack studies that mention the area. We hypothesized visualization nodes flow...