A5057922460- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrospun Nanofibers in Biomedical Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic Disease and Treatment Approaches
- Meningioma and schwannoma management
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiac and Coronary Surgery Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Spinal Dysraphism and Malformations
- Acute Ischemic Stroke Management
- Facial Nerve Paralysis Treatment and Research
- Circular RNAs in diseases
- Nerve injury and regeneration
- Galectins and Cancer Biology
- Climate Change and Health Impacts
- Congenital Heart Disease Studies
Huashan Hospital
2015-2024
Fudan University
2015-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2024
Shanghai Clinical Research Center
2020-2024
Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution features their histopathologic mechanism remains poorly understood. Methods- From February 2016 to 2018, total 19 men 28 women with 54 UIAs treated surgically were prospectively enrolled. The intraoperative observed gross pathology was compared enhancement on...
Restenosis caused by thrombopoiesis is one of the biggest hinders endovascular stent-graft used in small-diameter vessels. Rapid endothelialization lumen stent a promising approach to prevent thrombosis. In this study, we aimed at loading heparin, potent anticoagulants, and vascular endothelial growth factor (VEGF) into core poly(L-lactide-co-caprolactone) nanofiber via emulsion electrospinning. The was covered on applied treatment diseases such as aneurysm. morphologies electrospun...
Brain arteriovenous malformations (AVMs) are the most common cause of nontraumatic intracerebral hemorrhage in young adults. The genesis brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to pathogenesis AVMs.We used a large-scale miRNA analysis 16 samples including AVMs, hemangioblastoma, controls identify distinct signature. smooth muscle cells (AVMSMCs) were isolated identified by flow cytometry immunohistochemistry, candidate miRNAs then tested...
Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism unclear. In this study, we examine protein changes in cerebral and human brain vascular cells after cyclic mechanical stretch. We further explore relationship between cell reductions levels collagen types IV VI.Saccular aneurysms (n=10) were collected, temporal artery samples used as controls. Quantitative proteomics analyzed histopathological examined. Smooth...
An endovascular covered-stent has unique advantages in treating complex intracranial aneurysms; however, in-stent stenosis and late thrombosis have become the main factors affecting efficacy of treatment. Smooth-muscle-cell phenotypic modulation plays an important role thrombosis. Here, we determined using covered stents loaded with drugs to inhibit smooth-muscle-cell potentially lower incidence long-term complications.Nanofiber-covered were prepared coaxial electrospinning, core solution...
We report a novel graphene-oxide (GO) enhanced polymer hydrogel (GPH) as promising embolic agent capable of treating cerebrovascular diseases and malignant tumors, using the trans-catheter arterial embolization (TAE) technique. Simply composed GO generation five poly(amidoamine) dendrimers (PAMAM-5), our rheology experiments reveal that GPH exhibits satisfactory mechanical strength, which resist high pressures blood flow. Subcutaneous on Sprague-Dawley (SD) rats demonstrate qualified...
Cerebral aneurysm growth is characterized by vessel wall frailness, although the underlying cellular mechanisms are unclear. Here, we examined relationship between inflammatory smooth muscle cells (SMCs) and endothelial (ECs) in cerebral aneurysms, including SMC-induced changes ECs. Five saccular aneurysms were collected five temporal artery samples used as controls. Cells cytokines detected immunohistochemistry TUNEL (transferase dUTP nick end labeling) assays performed to evaluate...
This study explored a new rosuvastatin calcium- and heparin-loaded poly(l-lactide-co-caprolactone) (PLCL) scaffold for covered stents treating aneurysms. The mechanism of rosuvastatin-induced endothelialization via vascular endothelial growth factor (VEGF)-A elevation was further explored. Rosu50, Rosu75, Rosu100, phosphate-buffered saline (PBS) nanofibrous scaffolds were fabricated by coaxial electrospinning observed electron microscopy. Anticoagulation pro-endothelialization properties...
OBJECT Coil embolization is a safe, efficient, and minimally invasive technique for the treatment of intracranial aneurysms. However, coil associated with higher risk recurrence than clip ligation. In this study, authors explore new approach through promotion endothelial progenitor cells (EPCs) to optimize endothelialization aneurysm neck reduce recurrence. METHODS A coiled model was created in 48 adult male Sprague-Dawley rats via microsurgery. Half these animals were treated rosuvastatin...
While previous single-cell RNA sequencing (scRNA-seq) studies have attempted to dissect intracranial aneurysm (IA), the primary molecular mechanism for IA pathogenesis remains unknown. Here, we uncovered alterations of cellular compositions, especially transcriptome changes vascular endothelial cells (ECs), in human IA.
Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after has always plagued neurosurgeons because endothelial layer aneurysm neck loses its integrity being embolized by coil. Bone marrow–derived progenitor cells (BM-EPCs) could be incorporated into injured endothelium and differentiate mature during vascular repairing processes. The aim our study to explore effects BM-EPCs on remodeling in a rat model abdominal aortic aneurysm. BM-EPC...
Abstract This study explored a new approach to enhance aneurysm (AN) neck endothelialization via erythropoietin (EPO)-induced endothelial progenitor cell (EPC) stimulation. Results suggest that EPO enhanced the of coiled embolization AN by stimulating EPCs vascular growth factor modulation. Thus, promotion with provides an additional therapeutic option for preventing recurrence ANs. Endovascular coil is attractive therapy cerebral ANs, but main problem affecting long-term outcomes. In this...
Abstract Aims This study aimed to find critical proteins involved in the development of intracranial aneurysm by comparing proteomes rabbit model and human aneurysms. Methods Five samples 5 superficial temporal artery samples, 4 control were collected for protein mass spectrometry. Four 6 used immunochemistry. Results Proteomic analysis revealed 180 significantly differentially expressed aneurysms 716 Among them, 57 both species, which 24 increased 33 decreased compared groups. Proteins...
Background Surgical treatment of posterior inferior cerebellar artery (PICA) aneurysms is challenging because many are nonsaccular and atherosclerotic. We report our tailored approach to PICA aneurysms, which based on angioarchitecture supplemented by high-resolution vessel wall MRI (HR-VW MRI) findings. Methods From March 2010 September 2020, 27 patients with 29 underwent surgical in institution. Since October 2016, HR-VW has been used for aneurysmal assessment. Clinical characteristics,...
Cerebral aneurysm (CA) is one of the most common cerebrovascular diseases. The study was conducted to investigate effect resveratrol (RES) on CA formation and its possible mechanisms.Murine model constructed by induced hypertension fed without (model group) or with RES (RES group). A Sham group used as a control. inflammatory response were examined morphologically histochemically. expression nuclear factor-κB (NF-κB), matrix metalloproteinase (MMP)-2, MMP-9 analyzed using qRT-PCR Western...