A5029529904- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Erythropoietin and Anemia Treatment
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Apelin-related biomedical research
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Neuroprotection
- Nanoparticle-Based Drug Delivery
- Vascular Anomalies and Treatments
- Neurological Disorders and Treatments
- Inertial Sensor and Navigation
- Atherosclerosis and Cardiovascular Diseases
- Aerospace Engineering and Control Systems
- Biomedical and Engineering Education
- Spacecraft Design and Technology
- Nerve injury and regeneration
- Vagus Nerve Stimulation Research
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Effects and Toxicity Studies
Shanghai Jiao Tong University
2020-2025
Ruijin Hospital
2024
Shanghai Sixth People's Hospital
2022-2024
China Academy of Space Technology
2024
Fudan University
2023
Zhongshan Hospital
2023
ATLAS Neuroengineering (Belgium)
2022
Abstract Background Microglia-mediated neuroinflammatory response following traumatic brain injury (TBI) is considered as a vital secondary factor, which drives trauma-induced neurodegeneration and lack of efficient treatment. ACT001, sesquiterpene lactone derivative, reportedly involved in alleviation inflammatory response. However, little known regarding its function regulating innate immune central nervous system (CNS) after TBI. This study aimed to investigate the role underlying...
Our previous studies suggest that human fat extract (FE) contains a variety of angiogenic factors and may provide an alternative treatment option for stroke. However, the therapeutic effect is largely limited due to its short half-life, inaccurate targeting.Herein, we leverage targeting abilities platelets (PLTs) lesion area stroke Arg-Gly-Asp (RGD) peptides blood vessels develop biomimetic nanocarrier capable delivering FE precisely treat The nanocarriers are comprised FE-encapsulated PLGA...
Stroke patients with diabetes have worse neurological outcomes than non-diabetic stroke patients, and treatments beneficial for are not necessarily effective diabetic patients. While stem cell-derived extracellular vesicles (EVs) show potential treating stroke, the results remain unsatisfactory due to lack of approaches retaining controlling EVs released into brain. Herein, a glucose/reactive oxygen species dual-responsive hydrogel showing excellent injectability, biocompatibility,...
Vascular cognitive impairment (VCI) is the second-leading cause of dementia worldwide, which caused by cerebrovascular diseases or relevant risk factors. However, there are no appropriate animal models, can be used to study changes neuropathology in human VCI. To better understand development VCI, we modified three mouse models chronical vascular diseases, and further compared advantage disadvantage these models. We hope establish a more suitable model mimicking VCI beings.Adult male C57/BL6...
The crosstalk between reactive astrocytes and infiltrated immune cells plays a critical role in maintaining blood-brain barrier (BBB) integrity. However, how interact with the effect of their interaction on BBB integrity after hemorrhagic stroke are still unclear. By performing RNA sequencing that were activated by interleukin-1α (IL-1α), tumor necrosis factor α (TNFα), complement component 1q (C1q) treatment, we found CCL5 was among top upregulated genes. Immunostaining western blot results...
Astrocytes undergo disease-specific transcriptomic changes upon brain injury. However, phenotypic of astrocytes and their functions remain unclear after hemorrhagic stroke. Here we reported stroke induced a group inflammatory reactive with high expression Gfap Vimentin, as well inflammation-related genes lipocalin-2 (Lcn2), Complement component 3 (C3), Serpina3n. In addition, demonstrated that depletion microglia but not macrophages inhibited the in astrocytes. RNA sequencing showed...
Epilepsy, a neurological disorder marked by recurrent, unprovoked seizures, is often linked to dysregulated iron metabolism, resulting in overload and subsequent cellular dysfunction or death within epileptogenic regions. We proposed specific, noninvasive technique using paramagnetic susceptibility imaging via magnetic resonance quantify vivo brain levels, aiming enhance our understanding of epilepsy pathology improve diagnostic accuracy. Our histopathological studies demonstrated that...
Numerous hemorrhagic disorders, particularly those presenting deep hemorrhage, pose diagnostic challenges, often leading to delayed treatment and severe outcomes. Near-infrared (NIR)-II fluorescence imaging offers advantages such as tissue penetration, real-time visualization, a high signal-to-background ratio, making it highly suitable for diagnosing diseases. In this study, an NIR-II fluorescent probe LJ-2P carrying carboxylic phosphoric acid groups is successfully applied demonstrates...
Abstract Background: The effective therapeutics for vascular dementia are still lacking. Here, we designed a novel derived peptide of erythropoietin-DEPO and evaluated its safety, erythropoiesis effect neuroprotective effects in mice dementia. Methods: DEPO was injected to C57BL6 (n=5) 4-8 weeks, venous blood collected at 1, 2, 4 weeks after treatment evaluating the safety DEPO. Neuroprotective were studied both cultured neurons (n=10/group). After 4-week administration, neurobehavioral...