A5100775339- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Viral Infections and Vectors
- Pharmacological Effects of Natural Compounds
- Grit, Self-Efficacy, and Motivation
- Advanced Glycation End Products research
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Quinazolinone synthesis and applications
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Garlic and Onion Studies
- Advanced biosensing and bioanalysis techniques
- Polysaccharides Composition and Applications
- Second Language Learning and Teaching
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Cancer therapeutics and mechanisms
- Sulfur Compounds in Biology
Weifang Medical University
2012-2024
Harbin University of Commerce
2024
Ministry of Education of the People's Republic of China
2024
Bristol-Myers Squibb (United States)
2019-2021
Xiangya Hospital Central South University
2019
Central South University
2019
UNSW Sydney
2019
Southern Medical University
2016
Capital Medical University
2016
Henan Agricultural University
2016
RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, has been identified potential target for treatment various immunological disorders psoriasis, psoriatic arthritis, inflammatory bowel diseases. Structure computer-assisted drug design led to identification novel series tricyclic inverse agonists with significantly improved in vitro activity reporter (Gal4) human whole blood assays compared our...
Novel tricyclic analogues were designed, synthesized, and evaluated as RORγt inverse agonists. Several of these compounds potent in an IL-17 human whole blood assay exhibited excellent oral bioavailability mouse pharmacokinetic studies. This led to the identification compound 5, which displayed dose-dependent inhibition IL-17F production a IL-2/IL-23 stimulated pharmacodynamic model. In addition, 5 was studied acanthosis imiquimod-induced models skin inflammation, where it demonstrated...
Oxidative stress due to excessive reactive oxygen species (ROS) production in the skin microenvironment is one of main mechanisms psoriasis pathogenesis. A nano drug delivery system based on ROS-responsive release can enhance at target site. In this study, a ROS-sensitive material methoxypolyethylene glycol-thioether-thiol (mPEG-SS) was synthesized using mPEG as parent structure with sulfide structural modification. An mPEG-SS-calcipotriol (mPEG-SS-CPT, PSC) nano-micelle percutaneous...
As immune regulatory and effector cells, monocytes play an important role in the blood-extracorporeal circuit contact-related acute lung injury patients undergoing cardiopulmonary bypass (CPB). However, circulating are phenotypically functionally heterogeneous, so we characterised how immature affect induced by CPB.The identification dynamic changes monocyte subsets were monitored flow cytometry CPB a rat model of CPB. The differentiation migration explored vitro cultures adoptive transfer...
SAR efforts directed at identifying RORγt inverse agonists structurally different from our clinical compound 1 (BMS-986251) led to tricyclic-carbocyclic analogues represented by 3–7 and culminated in the identification of 3d (BMS-986313), with structural differences distinct 1. The X-ray co-crystal structure ligand binding domain revealed several key interactions, which are vitro vivo PK profiles described. In addition, we demonstrate robust efficacy two preclinical models psoriasis—the...
Immobilized metal ion affinity chromatography (IMAC) adsorbents generally have excellent for histidine-rich proteins. However, the leaching of ions from adsorbent usually affects its adsorption performance, which greatly reusable performance adsorbent, resulting in many limitations practical applications. Herein, a novel IMAC i.e., Cu(II)-loaded polydopamine-coated urchin-like titanate microspheres (Cu-PDA-UTMS), was prepared via coordination to make Cu uniformly decorate microspheres. The...
Tick-borne diseases are one of the most important classes disease in animal husbandry and cause severe economic losses. In this study, 660 adult female ticks were collected from sheep nine localities Henan Province, China. All identified as Haemaphysalis longicornis, confirmed with light microscopy PCR amplification. The pathogens these included bacteria genus Anaplasma (Anaplasma ovis, A. bovis, phagocytophilum) piroplasmal protozoans (Theileria luwenshuni, Babesia motasi). Our results show...
HIV-1 Tat is an important regulatory protein involved in AIDS pathogenesis. However, the immunoprofiles of anti-Tat responses remain unclear. We analysed antibody and neutralizing activities. Out 326 HIV-1-seropositive individuals, 12.9% were positive for antibodies. found six different immunological profiles responses: full-potential response, combined N-specific C-specific full-length Tat-specific response Tat-related response. These represent two types major complete alternative C-prone A...
Despite the extensive body of literature on correlation between family dynamics and academic achievement among students, there remains a notable gap in research investigating influence parental educational involvement student learning engagement. Based developmental-ecological model engagement relevant theoretical frameworks, this study used quantitative analysis method to construct chain mediation test relationship middle school as well potential mediating role gratitude hope. This employed...
Abstract This research aimed to investigate the pharmacological components for liver stagnation and spleen deficiency syndrome (LSSDS) of Evodia rutaecarpa (also called Yu HuangLian [YHL]) by exploring spectrum–effect relationship between fingerprints actions. The 17 batches YHL with different preparation conditions according Box–Behnken Design were generated analyzed identify common peaks HPLC FT‐IR. Vasoactive intestinal peptide ( vip ), substance P, 5‐HT levels in colon sample measured...
<b>BACKGROUND:</b> Type 2 innate lymphoid cells (ILC2s) were shown to be involved in Th2-type immune responses allergic disease animal models. ILC2s enrichment was nasal polyps chronic rhinosinusitis (CRS) patients and peripheral blood from asthma models; the role of ILC2s9 contribution Th2 response CRS remains investigated. <b>AIMS:</b> We hypothesized that there would enhanced expression with asthma, which may show correlation clinical features. <b>METHODS:</b> 6 ,5 Asthma 5 healthy...
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Abstract involving the selective, direct reductive debromination reaction of α‐hydroxy bromide (II) as key step
Pharmacology classes has been given with full English to medical international students since year 2005 in our school.According the different characteristics,we improved and explored teaching methods of pharmacology gradually.In this paper,in order improve level effectiveness pharmacology,we described some experience methods,and gave comparison results before after changing. Key words: International students; Pharmacology; Teaching method