A5040868085- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Traditional Chinese Medicine Analysis
- Monetary Policy and Economic Impact
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Market Dynamics and Volatility
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- HIV Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Kruppel-like factors research
- Plant-based Medicinal Research
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Chemotherapy-induced cardiotoxicity and mitigation
- Energy, Environment, Economic Growth
- Alkaloids: synthesis and pharmacology
- Circular RNAs in diseases
- Plant-derived Lignans Synthesis and Bioactivity
Renmin University of China
2019-2024
China Pharmaceutical University
2017-2024
Shenzhen Bioeasy Biotechnology (China)
2021-2024
Mellanox Technologies (Israel)
2021
Uniwersytet SWPS
2021
The University of Tokyo
2021
Stomatology Hospital
2020
The University of Texas MD Anderson Cancer Center
2019
Army Medical University
2012-2017
New York Genome Center
2017
Background Doxorubicin (DOX) is one of the most potent antitumor agents available; however, its clinical use limited because risk severe cardiotoxicity. Though numerous studies have ascribed DOX cardiomyopathy to specific cellular pathways, precise mechanism remains obscure. Sini decoction (SND) a well-known formula Traditional Chinese Medicine (TCM) and considered as efficient against DOX-induced cardiomyopathy. However, action mechanisms are not well known due complex components....
Abstract The exposure of healthy subjects to high altitude represents a model explore the pathophysiology diseases related tissue hypoxia. We explored plasma metabolomics approach detect alterations induced by altitude. Plasma samples were collected from 60 both on plain and at (5300 m). Metabolite profiling was performed gas chromatography-mass spectrometry (GC-MS) ultra-performance liquid chromatography-quadrupole time-of-flight mass (UPLC-QTOFMS) in conjunction with univariate...
Rhynchophylline antagonizes Parkinson’s disease through alleviating neuroinflammation and regulating metabolic disorders.
HIV-1 Tat protein is released by infected cells and can affect bystander uninfected T induce numerous biological responses which contribute to its pathogenesis. To elucidate the complex pathogenic mechanism, we conducted a comprehensive investigation on protein-related extracellular intracellular metabolic changes in Jurkat T-cells using combined gas chromatography–mass spectrometry (GC-MS), reversed-phase liquid (RPLC-MS) hydrophilic interaction (HILIC-MS)-based metabonomics approach....
Acute liver failure (ALF) is a serious clinical disorder with high fatality rates. Mahuang decoction (MHD), well-known traditional Chinese medicine, has multiple pharmacological effects, such as anti-inflammation, anti-allergy, anti-asthma, and anti-hyperglycemia. In this study, we investigated the protective effect of MHD against ALF. lipopolysaccharide D-galactosamine (LPS/D-GalN)-induced ALF mouse model, elevated activities serum alanine aspartate transaminases well pathological damage...
A “system to system” strategy of correlating drug-related and drug-induced UHPLC-Q-TOFMS serum metabolomic profiles was developed screen effective constituents.
As a typical model of hypoxia‑induced excessive erythrocytosis, high altitude polycythemia (HAPC) results in microcirculation disturbance, aggravates tissue hypoxia and severe clinical outcome, without any effective intervention methods except for returning to an oxygen‑rich environment. The present study aimed explore potential therapeutic targets which may participate the recovery HAPC by studying mechanisms reducing hemoglobin (HB) concentration during re‑oxygenation. A total 14 13...
Background: Hypoxia appears in a number of extreme environments, including high altitudes, the deep sea, and during aviation, occurs cancer, cardiovascular disease, respiratory failures neurological disorders. Though it is well recognized that hypoxic preconditioning (HPC) exerts endogenous neuroprotective effect against severe hypoxia, mediators underlying molecular mechanism for protective are still not fully understood. This study established hippocampus metabolomics approach to explore...
Hypoxia induces cardiomyocytes injury, which further triggers the occurrence and development of cardiovascular diseases. There is a paucity specific treatment options available with proven efficacy. Chinese patented pharmaceutical product Salidroside (Sal) has potent efficacy on treating hypoxic injury. However, molecular mechanism remains obscure. In present study, UPLC-QTOFMS-based metabolomic method combined cell viability apoptosis assays were established to explore therapeutic...
Hypoxic preconditioning (HPC) is well‑known to exert a protective effect against hypoxic injury; however, the underlying molecular mechanism remains unclear. The present study utilized serum metabolomics approach detect alterations associated with HPC. In study, an animal model of HPC was established by exposing adult BALB/c mice acute repetitive hypoxia four times. samples were collected orbital blood sampling. Metabolite profiling performed using ultra‑performance liquid...
Interleukin (IL)‑1β is a key promotor in the pathogenesis of temporomandibular joint osteoarthritis. Differentiation stem cells to cartilage crucial repair mechanism articular damage, and IL‑1β has been reported impede differentiation by upregulating secretion IL‑6, an important inflammatory factor. Long non‑coding RNAs (lncRNAs) regulate number physiological pathological processes, but whether lncRNA AK094629 contributes mediated induction inflammation remains unclear. Therefore, aim...
e16003 Background: Hepatocellular Carcinoma (HCC) patients has a high postoperative recurrence within 2 years and low 5-year survival rate. However, molecular mechanisms for early are poorly understood. Immune checkpoint blockades (ICBs) show clinical benefits in HCC, with the immune microenvironment influencing ICBs therapeutic effects. Exploring relationship between intratumoral heterogeneity (ITH), tumor neoantigen burden (TNB), human leukocyte antigen loss of heterozygosity (HLA LOH) can...
Bacterial infection is a major threat to global public health, and can cause serious diseases such as bacterial skin foodborne diseases. It essential develop new method rapidly diagnose clinical multiple infections monitor food microbial contamination in production sites real-time. In this work, we developed 4-mercaptophenylboronic acid gold nanoparticles (4-MPBA-AuNPs)-functionalized hydrogel microneedle (MPBA-H-MN) for bacteria detection interstitial fluid. MPBA-H-MN could conveniently...
Abstract Background Protein A, protein G and L are three well-defined immunoglobulin (Ig)-binding proteins (IBPs), which show affinity for specific sites on Ig of mammalian hosts. Although the precise functions these molecules not fully understood, it is thought that they play an important role in pathogenicity bacteria. The single domains were all demonstrated to have function bind Ig. Whether combinations Ig-binding various IBPs could exhibit useful novel binding interesting. Results We...
HIV-1 Tat is an important regulatory protein involved in AIDS pathogenesis. However, the immunoprofiles of anti-Tat responses remain unclear. We analysed antibody and neutralizing activities. Out 326 HIV-1-seropositive individuals, 12.9% were positive for antibodies. found six different immunological profiles responses: full-potential response, combined N-specific C-specific full-length Tat-specific response Tat-related response. These represent two types major complete alternative C-prone A...
Approximately 1-2% of non-small cell lung cancer (NSCLC) patients harbor RET (rearranged during transfection) fusions. The oncogenic fusions could lead to constitutive kinase activation and oncogenesis.1746 Chinese NSCLC were analyzed in this study. Tumor tissues collected, formalin fixed, paraffin-embedded (FFPE) archived. Peripheral blood (PB) samples also collected from each patient as control. In addition, we selected 17 them for cfDNA NGS testing 14 tumor immunohistochemistry using...