A5069470888- Radiation Therapy and Dosimetry
- Colorectal Cancer Screening and Detection
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Graphene and Nanomaterials Applications
- RNA and protein synthesis mechanisms
- Nanoparticles: synthesis and applications
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Machine Learning in Bioinformatics
- Gene expression and cancer classification
- T-cell and Retrovirus Studies
- COVID-19 diagnosis using AI
- Carcinogens and Genotoxicity Assessment
- Cancer-related Molecular Pathways
- Radiopharmaceutical Chemistry and Applications
- Food Quality and Safety Studies
Nanjing Tech University
2024
University of Chinese Academy of Sciences
2021
Institute of Computing Technology
2017
Chinese Academy of Sciences
2017
Peking University
2013-2014
Peking University Third Hospital
2013-2014
Abstract Gene set enrichment (GSE) analysis plays an essential role in extracting biological insight from genome-scale experiments. ORA (overrepresentation analysis), FCS (functional class scoring), and PT (pathway topology) approaches are three generations of GSE methods along the timeline development. Previous versions KOBAS provided services based on just method. Here we presented version 3.0 KOBAS, which is named KOBAS-i (short for intelligent version). It introduced a novel machine...
External beam radiation (EBRT) and (125)I seeds continuous low dose rate (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT CLDR on cancer cells. A549 human cell line was thus exposed different doses CLDR. more efficient inhibit growth than EBRT. induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory may be, at least in part, due Bax/Bcl2 ratio cyclin B1-mediated G2/M arrest.
Abstract Increasing evidence proves the essential regulatory roles of non-coding RNAs (ncRNAs) in biological processes. However, characterizing specific functions ncRNAs remains a challenging task, owing to intensive consumption experimental approaches. Here, we present an online platform ncFANs v2.0 that is significantly enhanced version our previous provide multiple computational methods for ncRNA functional annotation. Specifically, was updated embed three modules, including ncFANs-NET,...
Abstract The use of a combination several antibacterial agents for therapy holds great promise in reducing the dosage and side effects these agents, improving their efficiency, inducing potential synergistic therapeutic effects. Herein, this study provides an innovative treatment strategy by synergistically combining R12‐AgNPs with H 2 O therapy. were simply produced supernatant ionizing radiation‐tolerant bacterium Deinococcus wulumuqiensis R12 one‐step under room temperature. In comparison...
// Shuangtao Zhao 1, * , Shuangsang Fang 2, Yanhua Liu 3, 4, 5, Xixi Li 6 Shengyou Liao 2 Jinwen Chen Jingjia Lianhe Hui Wei Zhou 5 Wenzhi Shen Xiaoli Dong Rong Xiang Luhua Wang 1 Yi Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Peking Union Medical College and Chinese Academy Sciences, Beijing, China The Key Laboratory Intelligent Information Processing, Institute Computing Technology, 3 School Medicine, Nankai University, Tianjin, 4 Collaborative Innovation...
To determine the biological effectiveness of single, fractionated and continuous low dose rate irradiation on human colorectal cancer cell line CL187 in vitro explore cellular mechanisms. The cells were exposed to radiation 6 MV X-ray at a high 4Gy/min 125I seed 2.77 cGy/h. Three groups employed: single group (SDR), (FDR) by 2Gy/f (CLDR). Four doses 2, 4, 8Gy chosen without as control. responses distinct modes evaluated colony-forming assay, cycle progression well apoptosis analysis. In...
Abstract Background To characterize the effect of combined treatment anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine ( 125 I) seed radiation in human colorectal cancer. Methods We treated LS180 cells with I continuous low dose rate presence absence 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, molecular pathways following treatments were analyzed vitro. Results sensitizer enhancement ratio was...
The progress in Colorectal cancer (CRC) screening and management has resulted an unprecedented caseload for histopathological diagnosis. While artificial intelligence (AI) presents a potential solution, the predominant emphasis on slide-level aggregation performance without thorough verification of each location, impedes both explainability transparency. Effectively addressing these challenges is crucial to ensuring reliability efficacy AI histology applications.
Introduction: Early detection of esophageal squamous cancer is essential for favorable prognosis patients. However the ability to detect precancerous lesion and early substantially subject operator experience. We develop an artificial intelligence model(AIM) automated these lesions, trying reduce interobserver variability improve diagnosis cancer. Methods: used 1014 narrow band images(NBI) lesions cancers in 95 cases 1071 NBI images non-cancerous 198 from 2017, train model. 1478 malignant 59...
Objective To determine the biological effectiveness of 125I radioactive seeds with continuous low dose rate radiation on human esophageal cancer cell line KYSE150 in vitro and explore underlying cellular mechanisms.Methods The cells were divided into three groups:control group,single group (SDR) (125 I-CLDR).The exposed to X-ray at a high 1.052 Gy/min or 2.77 cGy/h.The responses two modes irradiation evaluated by colony-forming assay,cell apoptosis as well cycle analysis.Furthermore,the...
Objective To investigate the effect of cetuximab (C225) on radiosensitivity colorectal cancer cells CL187 and underlying mechanism.Methods Cell survival was detected by colony forming assay.The levels apoptosis cell cycle distribution were determined flow cytometer.The mitotic ratio measured Wright' s-Giemsa mixed coloring method.The protein Bax Bcl2 Western blot.Results The sensitizing enhancement C225 approximately 1.4.C225 treatment 125I seed radiation induced G1 arrest individually.C225...
The use of a combination several antibacterial agents for therapy holds great promise in reducing the dosage and side effects these agents, improving their efficiency, inducing potential synergistic therapeutic effects. Herein, R12-AgNPs were produced with supernatant an ionizing radiation-tolerant bacterium Deinococcus wulumuqiensis R12 by one-step under room temperature. biosynthesized AgNPs presented fascinating activity peroxidase-like properties, which endowed it capability to catalyse...