Cigarette smoke (CS)-caused ferroptosis was involved in the pathogenesis of COPD, but role lung epithelial injury and inflammation is not clear. Rats were treated with CS or CUR BEAS-2B cells exposed to extract (CSE), ferrostatin-1 (Fer-1), deferoxamine (DFO), detect reactive oxygen species (ROS) accumulation, lipid peroxidation, iron overload, ferroptosis-related protein, which characteristic changes ferroptosis. Compared control group, CSE-treated had more cell death, higher cytotoxicity,...

Purpose: Autophagy plays essential roles in the development of COPD. We aim to identify and validate potential autophagy-related genes COPD through bioinformatics analysis experiment validation. Methods: The mRNA expression profile dataset GSE38974 was obtained from GEO database. differentially expressed were screened by R software. Then, protein–protein interactions (PPI), correlation analysis, gene-ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway applied for genes....

Inflammation is a critical component of tumor progression, and it modifies the microenvironment by various mechanisms. Here, we explore effect inflammatory response on in colorectal cancer (CRC). A prognostic signature consisting inflammation-related genes (IRGs) was constructed verified based bioinformatics analysis. IRG risk model identified as an independent factor CRC, related to biological processes extracellular matrix, cell adhesion angiogenesis. The score predicted clinical benefit...

ICS are anti-inflammatory agents which have been suggested to benefit people with worsening symptoms of COPD, by improving lung function, reducing exacerbation disease, and enhancing overall quality life. This systematic review meta-analysis explored the association risk pneumonia in COPD patients that were undergoing treatment using alone or together LABAs LAMAs. PubMed, Cochrane Library EMBASE systematically searched through August 1, 2019; only double-blinded randomized controlled trials...

Abstract Pulmonary hypertension (PH) remains a life-limiting disease characterized by pulmonary vascular remodelling due to aberrant proliferation and migration of artery smooth muscle cells (PASMCs), thus leading raised arterial pressure right ventricular hypertrophy. Secreted glycoprotein follistatin-like 1 (FSTL1) has been reported ameliorate tissue in cardiovascular injuries. However, the role FSTL1 deranged arteries elusive. We found that there were higher serum levels patients with PH...

Abstract Background Salt stress is often associated with excessive production of reactive oxygen species (ROS). Oxidative caused by the accumulation ROS a major factor that negatively affects crop growth and yield. Root primary organ senses transmits salt signal to whole plant. How oxidative affect redox sensitive proteins in roots not known. Results In this study, proteome sugar beet M14 under was investigated. Using iTRAQ reporters, we determined significant changes abundance many (2305 at...

Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets apply immunotherapy effectively in LGG, the status function immune infiltration microenvironment must be explored.Four independent cohorts comprising 1,853 patients were enrolled for bioinformatics analysis. We used ConsensusClusterPlus to cluster into four different subtypes based on infiltration. The immune-infiltration signature...

Salt stress can cause cellular dehydration, which induces oxidative by increasing the production of reactive oxygen species (ROS) in plants. They may play signaling roles and structural damages to cells. To overcome negative impacts, plant ROS scavenging system plays a vital role maintaining redox homeostasis. The special sugar beet apomictic monosomic additional M14 line (BvM14) showed strong salt tolerance. Comparative proteomics revealed that six antioxidant enzymes (glycolate oxidase...

To determine the biological effectiveness of single, fractionated and continuous low dose rate irradiation on human colorectal cancer cell line CL187 in vitro explore cellular mechanisms. The cells were exposed to radiation 6 MV X-ray at a high 4Gy/min 125I seed 2.77 cGy/h. Three groups employed: single group (SDR), (FDR) by 2Gy/f (CLDR). Four doses 2, 4, 8Gy chosen without as control. responses distinct modes evaluated colony-forming assay, cycle progression well apoptosis analysis. In...

Abstract Background To characterize the effect of combined treatment anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine ( 125 I) seed radiation in human colorectal cancer. Methods We treated LS180 cells with I continuous low dose rate presence absence 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, molecular pathways following treatments were analyzed vitro. Results sensitizer enhancement ratio was...

Sugar beet is one of the most important sugar crops in world. It contributes greatly to global production, but salt stress negatively affects crop yield. WD40 proteins play roles plant growth and response abiotic stresses through their involvement a variety biological processes, such as signal transduction, histone modification, ubiquitination, RNA processing. The protein family has been well-studied Arabidopsis thaliana, rice other plants, systematic analysis not reported. In this study,...

Introduction: Trifluridine/tipiracil (TAS-102) and fruquintinib are novel antitumor agents for patients with refractory metastatic colorectal cancer (mCRC). We conducted a retrospective study to explore the clinical efficacy drug toxicities of combination therapy TAS-102 in real-life practice. Methods: Between March 2021 February 2023, at two different centers mCRC who failed or more lines prior received were recruited. Results: In total, 32 included analysis. The objective response rate...

Background Early neurological deterioration (END) is a frequent complication in patients with perforating artery territory infarction (PAI), leading to poorer outcomes. Therefore, we aimed apply machine learning (ML) algorithms predict the occurrence of END PAI and investigate related risk factors. Methods This retrospective study analyzed cohort patients, excluding those severe stenosis parent artery. We included demographic characteristics, clinical features, laboratory data, imaging...

Post-translational modifications (PTMs) are important molecular processes that regulate organismal responses to different stresses. Ubiquitination modification is not only involved in human health but also plays crucial roles plant growth, development, and environmental In this study, we investigated the ubiquitination proteome changes salt-tolerant sugar beet monomeric additional line M14 under salt stress treatments. Based on expression of key genes system ubiquitination-modified proteins...

Objective. Psychological status plays a vital role in the recovery young ischemic stroke patients. However, few reports on psychological symptoms Chinese patients have been published. In present study, we aimed to outline of and its risk factors at three months after their stroke. Methods. 364 with 384 age‐matched healthy controls were consecutively recruited from our study hospitals mainland China between June 2018 November 2020. Social demographic clinical data collected all enrolled...

To observe the effect of bevacizumab in combination with β-elemene on subcutaneous xenografts established from HCT-116 human colon cancer cells, explore underlying mechanisms involved, and provide more options for treatment advanced colorectal cancer.Mice were randomly divided into four groups: control, β-elemene, treatment. Tumor volume was measured tumor inhibition rate coefficient drug interaction (CDI) calculated. The pathological morphological features tissues observed. Protein...

Salt stress is a major abiotic that limits plant growth, development and productivity. Studying the molecular mechanisms of salt tolerance may help to enhance crop Sugar beet monosomic addition line M14 exhibits stress. In this work, changes in BvM14 proteome redox induced by were analyzed using multiplex iodoTMTRAQ double labeling quantitative proteomics approach. A total 80 proteins differentially expressed under Interestingly, 48 redoxed peptides identified for 42 potential...

Brain atrophy represents a final common pathway for pathological processes in patients with cerebral small vessel disease (CSVD) and is now recognized as strong independent predictor of clinical status progression. The mechanism underlying brain CSVD not yet fully comprehended. This study aims to investigate the association morphologic features intracranial distal arteries (A2, M2, P2 more distal) different structures [gray matter volume (GMV), white (WMV), cerebrospinal fluid (CSFV)]....

BACKGROUNDCrizotinib-induce hepatotoxicity is rare and non-specific, severe can develop into fatal liver failure.Herein, we report a case of crizotinib-induced failure in 37-year-old Asian patient. CASE SUMMARYThe patient complained dyspnea upper abdominal pain for week August 2017.He was diagnosed with anaplastic lymphoma kinase-rearranged lung adenocarcinoma combined multiple distant metastases.Crizotinib initiated as first-line treatment at dosage 250 mg twice daily.No adverse effects...

Objective: To investigate the impact of immediate cessation antiviral therapy on postpartum liver function and factors influencing abnormality in mothers with chronic hepatitis B virus infection. Methods: A retrospective cohort study was conducted. One hundred eighty-eight pregnant women HBV DNA level > 2×106 IU/ml were enrolled from June 2014 to 2018. Demographic information clinical data load during gravidity, intrapartum period collected. According treatment recommendations pregnancy,...