A5076923853- COVID-19 Clinical Research Studies
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Single-cell and spatial transcriptomics
- Cardiomyopathy and Myosin Studies
- Atherosclerosis and Cardiovascular Diseases
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Ion channel regulation and function
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Particle physics theoretical and experimental studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Influenza Virus Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Quantum Chromodynamics and Particle Interactions
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Cellular transport and secretion
University of Pittsburgh
2023-2025
Henan Normal University
2024
Regenerative Medicine Institute
2022
University of Illinois Chicago
2014-2022
Illinois College
2017-2022
Jiujiang University
2022
Jinshan Hospital of Fudan University
2021
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
Second People’s Hospital of Huai’an
2021
Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression profiles. RNA-Sequencing of the brain, lung, and heart translatome identified specific pathways, transporters cell-surface markers expressed endothelium each organ, which can be visualized at http://www.rehmanlab.org/ribo. We found that express genes typically surrounding tissues such as synaptic vesicle brain cardiac contractile...
Vaccine hesitancy and emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern (VOCs) escaping vaccine-induced immune responses highlight the urgency for new COVID-19 therapeutics. Engineered angiotensin-converting enzyme (ACE2) proteins with augmented binding affinities SARS-CoV-2 spike (S) protein may prove to be especially efficacious against multiple variants. Using molecular dynamics simulations functional assays, we show that three amino acid...
Abstract Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid homeostasis and normalizing leukocyte transmigration. However, mechanisms regeneration remain poorly understood. Here we show that hematopoietic developmental transcription factor Sox17 promotes in endotoxemia model injury. Genetic lineage tracing studies demonstrate native endothelium itself serves as primary source cells repopulating vessel wall following We identify a key regulator...
Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs) within a bed; however, little is known about how distinct subpopulations in particular organ respond to an inflammatory stimulus. We performed single-cell RNA-Seq 35,973 lung ECs obtained during baseline as well postinjury time points after injury induced by LPS. Seurat clustering and gene expression pathway analysis identified 2 major microvascular endothelium, subpopulation enriched for immune...
The pandemic of coronavirus disease 2019 (COVID-19) has been the foremost modern global public health challenge. airway is primary target in severe acute respiratory distress syndrome 2 (SARS-CoV-2) infection, with substantial cell death and lung injury being signature hallmarks exposure. viral factors that contribute to remain incompletely understood. Thus, this study investigated role open reading frame 7b (Orf7b), an accessory protein virus, causing injury. In screening proteins, we...
Monoclonal antibodies targeting the SARS-CoV-2 spike (S) glycoprotein neutralize infection and are efficacious for treatment of mild-to-moderate COVID-19. However, variants have emerged that partially or fully escape monoclonal in clinical use. Notably, BA.2 sublineage B.1.1.529/omicron escapes nearly all currently authorized therapeutic Decoy receptors, which based on soluble forms host entry receptor ACE2, an alternative strategy broadly bind block S from related betacoronaviruses. The...
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The mechanisms underlying the dedifferentiation and lineage conversion of adult human fibroblasts into functional endothelial cells have not yet been fully defined. Furthermore, it is known whether fibroblast recapitulates generation multipotent progenitors during embryonic development, which give rise to hematopoietic cell lineages. Here we established role developmental transcription factor SOX17 in regulating bilineage by intermediate progenitors.CD34+ were generated after dermal...
Cigarette smoking is associated with a higher risk of ICU admissions among patients flu. However, the etiological mechanism by which cigarette smoke (CS) exacerbates flu remains poorly understood. Here, we show that mild dose influenza A virus promotes severe lung injury in mice preexposed to CS but not room air for 4 weeks. Real-time intravital (in vivo) imaging revealed development acute respiratory dysfunction CS- and flu-exposed was accumulation platelet-rich neutrophil-platelet...
Coronary microembolization (CME) is associated with progressive myocardial dysfunction despite restoration of coronary flow reserve (CFR). The potential pathophysiological role mast cells (MCs) remains unclear. Therefore, we induced CME in 18 miniswines and determined whether MC accumulation occurs their effects on local cytokine secretion [interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-alpha)]; cardiomyocyte apoptosis; collagen formation at day 1 (D1), 7 (D7), 30 (D30) after...
A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 MDMX. Some compounds showed potent moderate MDMX activities. Among them, compound A13 exhibited the most affinity MDMX, with a Ki 0.031 7.24 μM, respectively. was also agent against HCT116, MCF7, A549, IC50 values 6.17, 11.21, 12.49 Western blot analysis confirmed that upregulated expression MDM2, p53 by analysis. These results indicate is dual p53-MDM2 p53-MDMX inhibitor deserves...
Narrative nursing is an important clinical intervention model. It the practice of patient storytelling to share essence nursing. The current for biliary atresia (BA) mainly focuses on disease treatment and does not pay enough attention psychological state family members.To explore application value narrative in families children with BA.Sixty-four members BA our hospital from December 2017 October 2020 were retrospectively included divided into a study group (n = 32) control 32). was...
Summary IFNγ, a type II interferon secreted by immune cells, augments tissue responses to injury following pathogenic infections leading lethal acute lung (ALI). Alveolar macrophages (AM) abundantly express Toll-like receptor-4 and represent the primary cell of innate system in lungs. A fundamental question remains whether AM generation IFNg leads uncontrolled response perpetuated injury. LPS induced sustained increase levels unresolvable inflammatory mice lacking RGS2 but not null chimeric...
Kinematics restrict the ability of rare charm decays to explore charged Lepton Flavor Violation processes mediated by quark-level $c\to u \ell \tau$ transition. To fill gap, we propose exploring new physics (NP) through quasielastic scattering process $e^-p\to \tau^-\Lambda_c$ and polarization $\tau$ lepton. As analyzing modes for polarization, consider $\tau^-\to \pi^-\nu_{\tau}$, \rho^-\nu_{\tau}$, $\tau^- \to \ell^-\bar{\nu}_{\ell}\nu_{\tau}$, show that components can be extracted from...
Kinematics restricts the ability of rare charm decays to explore charged lepton-flavor-violation processes mediated by quark-level <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mi>c</a:mi><a:mo stretchy="false">→</a:mo><a:mi>u</a:mi><a:mo>ℓ</a:mo><a:mi>τ</a:mi></a:math> transition. To fill gap, we propose exploring new physics (NP) through quasielastic scattering process <d:math xmlns:d="http://www.w3.org/1998/Math/MathML"...
Vaccine hesitancy and continuing emergence of SARS-CoV-2 variants concern that may escape vaccine-induced immune responses highlight the urgent need for effective COVID-19 therapeutics. Monoclonal antibodies used in clinic have varying efficacies against distinct variants; thus, there is considerable interest engineered ACE2 peptides with augmented binding affinities Spike protein. These could therapeutic benefit multiple viral variants. Using molecular dynamics simulations, we show how...