A5017680293- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Hemophilia Treatment and Research
- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Congenital Diaphragmatic Hernia Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Psoriasis: Treatment and Pathogenesis
- Platelet Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Erythropoietin and Anemia Treatment
- Extracellular vesicles in disease
- Vitamin D Research Studies
- Endometriosis Research and Treatment
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Disorders and Syndromes
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Contact Dermatitis and Allergies
- Lipid metabolism and disorders
- Immune cells in cancer
University of Pittsburgh
2019-2024
Versiti Blood Center of Wisconsin
2023-2024
Medical College of Wisconsin
2024
Université de Strasbourg
2023
Inserm
2023
University of Kentucky
2023
University of Rochester
2023
Queen's University
2023
Medical University of Białystok
2014-2020
Helios Vogtland Klinikum Plauen
2020
During chronic kidney disease progression, kidney-specific risk factors for cardiovascular come into play. The present study investigated the impact of indoxyl sulfate, dietary tryptophan-derived uremic toxin, accumulated in blood patients with on hemostatic parameters, markers inflammation, oxidative stress and monocyte to macrophage transition. Fifty-one CKD not undergoing hemodialysis were enrolled study. Coagulation factors, fibrinolytic adhesion molecules, endothelial dysfunction...
Abstract Chronic kidney disease (CKD) is deemed to be a worldwide health concern connected with neurological manifestations. The etiology of central nervous system (CNS) disorders in CKD still not fully understood, however particular attention currently being paid the impact accumulated toxins. Indoxyl sulfate (IS) one most potent uremic purpose present study was assess IS concentrations cerebellum, brainstem, cortex, hypothalamus, and striatum hippocampus rats chronically exposed IS. To...
Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention uremic toxins, especially indoxyl sulfate (IS), which currently considered as non-classical CKD-specific factor for CVDs. The present study aimed examine the effect exposure IS on hemostatic system and arterial in model without greater interferences milieu consisting additional toxins....
Chronic kidney disease (CKD) patients are at high risk for thrombotic events. Indoxyl sulfate (IS) is one of the most potent uremic toxins that accumulates during CKD. Even though IS associated with an increased cardiovascular disease, its impact on events still remains not fully understood. The purpose study was to evaluate direct effect process. We examined acute exposure thrombus development induced by electric current in Wistar rats, intravital formation after laser-induced injury mice...
Abstract Respiratory infection by Pseudomonas aeruginosa , common in hospitalized immunocompromised and immunocompetent ventilated patients, can be life-threatening because of antibiotic resistance. This raises the question whether host’s immune system educated to combat this bacterium. Here we show that prior exposure a single low dose lipopolysaccharide (LPS) protects mice from lethal P. . LPS trained innate promoting expansion neutrophil interstitial macrophage populations distinguishable...
Coffee may exert a preventive effect on arterial thrombosis. Trigonelline is one of the most abundant compounds in coffee that undergoes pyrolysis upon roasting beans. The aim present study was to identify pyridinium formed trigonelline and investigate three them, i.e., 1-methylpyridine 1,3- 1,4-dimethylpyridine, experimentally induced thrombosis rats. 1,4-dimethylpyridine but not inhibited thrombus formation. 1,3-Dimethylpyridine platelet aggregation reduced fibrin formation platelet-rich...
Hypertension is a serious condition that can lead to many health problems. The mechanisms underlying this process are still not fully understood. kynurenine pathway may be involved in the occurrence and progression of hypertension. purpose study was examine activity peripheral rats with renovascular hypertension Goldblatt 2K1C model. induced experimental groups by constricting renal artery left kidney rats. Determination tryptophan (Trp) metabolites assessed high-performance liquid...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) exerts an important role in inflammatory processes, lipids homeostasis, and cardiometabolic disorders that are closely associated with psoriasis. The aim of the study was to analyze clinical diagnostic value serum PCSK9 concentrations their connections disease severity, inflammation, metabolic syndrome, impact systemic therapies psoriatic patients. enrolled thirty-five patients active plaque-type psoriasis eighteen healthy volunteers...
Whole lung tissue transcriptomic profiling studies in chronic obstructive pulmonary disease (COPD) have led to the identification of several genes associated with severity airflow limitation and/or presence emphysema, however, cell types driving these gene expression signatures remain unidentified.To determine specific changes severe COPD, we conducted single-cell RNA sequencing (scRNA seq) on n = 29,961 cells from peripheral parenchymal nonsmoking subjects without underlying (n 3) and...
Psoriasis is a chronic, inflammatory skin disease affecting 2–4% of the general population. Accompanying subjective symptoms (pruritus or pain) may cause decreased life quality including sleep disorders (SD). Sixty psoriatic patients fulfilled following questionnaires: Pittsburgh Sleep Quality Index (PSQI), STOP BANG for obstructive apnea syndrome (OSAS) assessment, and Restless Legs Syndrome (RLS) Severity Scale. Patients’ laboratory clinical data were also investigated. All obtained...
Psoriasis is a chronic, autoimmune, inflammatory skin disease affecting 2-4% of the general population, which nowadays even perceived as systemic illness. The nature this dermatosis may negatively influence patients' condition, life expectancy, and quality life, highlights severity problem need to perform further investigation. We aimed assess stress severity, physical activity patients with psoriasis in relation demographic clinical data comparison control group without dermatoses.A set...
Cigarette smoking is associated with a higher risk of ICU admissions among patients flu. However, the etiological mechanism by which cigarette smoke (CS) exacerbates flu remains poorly understood. Here, we show that mild dose influenza A virus promotes severe lung injury in mice preexposed to CS but not room air for 4 weeks. Real-time intravital (in vivo) imaging revealed development acute respiratory dysfunction CS- and flu-exposed was accumulation platelet-rich neutrophil-platelet...
Sickle cell disease (SCD)-associated chronic hemolysis promotes oxidative stress, inflammation, and thrombosis leading to organ damage, including liver damage. Hemoglobin scavenger receptor CD163 plays a protective role in SCD by scavenging both hemoglobin-haptoglobin complexes cell-free hemoglobin. A limited number of studies the past have shown positive correlation expression with poor outcomes patients SCD. However, regulation SCD-related hepatobiliary injury not been fully elucidated...
Chronic kidney disease (CKD) is an estimated risk factor for increased mortality and morbidity due to fibrinolytic system disturbances. Progressive loss of renal function leads retention uremic toxins. Anthranilic acid (AA) a tryptophan-derived toxin with multidirectional properties that can affect the hemostatic system. The goal this study was examine association between AA parameters fibrinolysis at different stages CKD. Patients CKD were divided into two groups: mild-to-moderate (n = 20)...
How transient hyperglycemia contributes to cerebro-vascular disease has been a challenge study under controlled physiological conditions. We use amplified, ultrashort laser-pulses physically disrupt brain-venule endothelium at targeted locations. This vessel disruption is performed in conjunction with from single injection of metabolically active D-glucose into healthy mice. The observed real-time responses laser-induced include rapid serum extravasation, platelet aggregation, and neutrophil...