A5063442011- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Anorectal Disease Treatments and Outcomes
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
- Adenosine and Purinergic Signaling
- Enhanced Recovery After Surgery
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
Second Affiliated Hospital of Dalian Medical University
2015-2025
Dalian Medical University
2015-2025
Daping Hospital
2024
Army Medical University
2024
Objective: To compare the short- and long-term outcomes between robotic gastrectomy (RG) laparoscopic (LG) for gastric cancer. Summary Background Data: The clinical of RG over LG have not yet been effectively demonstrated. Methods: This retrospective cohort study included 3,599 patients with cancer who underwent radical at eight high-volume hospitals in China from August 2016 to June 2019. Propensity score matching (PSM) was performed received LG. primary endpoint 3-year disease-free...
Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it reported that conserved and oxidative pentose phosphate pathway-associated circular RNA, circNOLC1, plays crucial role liver metastasis. It found circNOLC1 silencing reduces pathway-related intermediate metabolites elevates NADP+ /NADPH ratio intracellular ROS levels, thereby attenuating cell proliferation, migration, interacting with AZGP1 to activate...
Robotic-assisted total mesorectal excision (RaTME) may be associated with reduced conversion to an open approach and a higher rate of complete (TME); however, studies on its advantages in intersphincteric resection (ISR) are inadequate.
Introduction Cancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, development novel delivery systems for sustained release essential to improve therapeutic outcomes. Methods This study aimed develop a poly(trimethylene carbonate) (PTMC) membrane capable 5-FU enhance antitumor...
Prostate-specific membrane antigen (PSMA) ligand PET induces management changes in patients with prostate cancer. We aim to better characterize the impact of <sup>68</sup>Ga-PSMA-11 (<sup>68</sup>Ga-PSMA PET) on recurrent cancer a large prospective cohort. <b>Methods:</b> report after <sup>68</sup>Ga-PSMA PET, secondary endpoint multicenter trial men biochemical recurrence Pre-PET (Q1), post-PET (Q2), and posttreatment (Q3) questionnaires were sent referring physicians recording site...
Abstract Despite recent progress in the identification of genetic and molecular alternations colorectal carcinoma, precise pathogenesis remains unclear. NALP1 (nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 1) is a member nucleotide-binding family proteins that are key organization inflammasome. It reported plays central role cell apoptosis, pyroptosis, inflammatory reactions autoimmune diseases. DAC (5-aza-2-deoxycytidine) an antitumor drug useful to...
Tumor metastasis is an essential cause of the poor prognosis colon cancer. DC-SIGNR a C-type lectin that frequently found on human liver sinusoidal endothelial cells. LSECtin, which homologue DC-SIGNR, has been demonstrated to participate in cancer metastasis. Due similarities expression pattern and structure two proteins, we speculated could also be involved this process. Colon cells were treated with protein or control IgG, after cell migration, invasion, morphology assayed. Xenograft...
Abstract DC-SIGN is previously focused on its physiologic and pathophysiologic roles in immune cells. Little known about whether expressed malignant epithelial cells how participates tumor progression. Here we showed that expression was increased metastatic colorectal cancer (CRC) cell lines patient tissues. The overall survival CRC patients with positive remarkably reduced. Gain of function facilitated the metastases both vitro vivo, this effect reversed by miR-185. Lyn interacted...
Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. However, DC-SIGNR as a family member participates gastric liver metastasis remains unknown. The serum level was evaluated patients by ELISA. Manipulation expression BGC823 SGC7901 cell lines mediated lentivirus. Investigation the biological effects were verified MTT, wounding transwell vitro experiments on animals to confirm IVIS. Insights mechanism employed microarray...
Background Colon cancer has always been diagnosed at a late stage, which is associated with poor prognosis. The currently used serum tumor markers CEA and CA19-9 display low sensitivity specificity may not have diagnostic value in early stage colon cancer. Thus, there an urgent need to identify novel biomarkers for use the detection of Methods In this study, expression DC-SIGN DC-SIGNR was detected by enzyme-linked immunosorbent assay (ELISA). tissues immunohistochemistry (IHC). Results...
Primary gastrointestinal non-Hodgkin lymphoma (PGI NHL) is one of the most common types extranodal lymphoma, accounting for ~30-50% all lymphomas. The aim present study was to investigate clinical characteristics, diagnosis, treatment and prognosis patients with PGI NHL. A total 46 NHL (mean age, 50 years) were enrolled in this study, a male:female ratio 1.3:1. site stomach (52.2%), followed by colon (34.8%) small intestine (8.7%). symptoms included abdominal pain or discomfort (91.3%), loss...
Previous studies have reported that long noncoding RNAs (lncRNAs) acted as new players during tumorigenesis. Metallothionein also plays an important role in tumor progression. It is mainly considered to be involved the process of cell proliferation, oxidative stress, and multidrug resistance. However, potential involvement metallothionein-related lncRNAs colon cancer remains poorly understood. In our study, we found MT1M affected expression lncRNA STEAP3-AS1. STEAP3-AS1 located physical...
The P2X₇R (P2X₇ receptor) is an ATP-gated cation channel expressed in normal cells that participates both cell proliferation and apoptosis. Here, we have confirmed expression on murine P388D1 lymphoid neoplasm cells. In addition, ATP-stimulated was found to trigger increased intracellular calcium flux. Furthermore, silencing with short hairpin RNA blocking antibody significantly reduced the metastasis of lymph nodes. These results indicate inhibition function attenuates metastatic ability...
The aim of the present study was to investigate levels serum tumor biomarker carcinoembryonic antigen (CEA) in patients with carcinoma colon and rectum different clinical stages. Colorectal cancer (CRC) is one most commonly diagnosed types worldwide previous studies have reported rapidly updated therapeutic regimes. While majority focus on CRC as a single entity, certain distinguish (CC) from rectal (RC), there hypothesis stating that CC RC are two naturally entities. CEA be an important...
Abstract Liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin) plays an important regulatory role in a variety of diseases, including tumors. However, the underlying mechanism LSECtin gastric cancer (GC) remains largely unknown. In our research, promoted adhesion invasion GC cells, was involved lymphatic metastasis cells. Mechanistically, adhesion, proliferation migration cells by downregulating STAT1 expression. The circular RNA circFBXL4, which is regulated LSECtin,...
The present study aimed to compare the clinical outcomes of laparoscopic‑assisted surgery versus open for colorectal cancer and investigate oncological safety potential advantages disadvantages cancer. medical records from a total 160 patients who underwent between January 2009 2013 at Second Hospital Dalian Medical University (Dalian, China) were retrospectively analyzed. showed significant due minimally invasive nature compared with those surgery, namely, less blood loss (P=0.002), shorter...
Laparoscopic total mesorectal excision (L-TME) is difficult to perform because of its technical shortcomings in cases anatomical condition. In such situations, robotic TME (R-TME) tends be the procedure choice. This study aimed compare R-TME and L-TME treatments for mid-low rectal cancer patients with conditions.This retrospective single-center examined data from 01/2019 02/2021 conditions. Perioperative data, short-term outcomes, 2-year oncologic outcomes were compared between groups.The...
Background Total mesorectal excision (TME), represents a key technique in radical surgery for rectal cancer. This study aimed to construct preoperative nomogram predicting the surgical difficulty of laparoscopic total (L-TME) and investigate whether there were potential benefits robotic TME (R-TME) patients with technically challenging Methods Consecutive midlow cancer receiving included. A predict L-TME was established validated. Patients screened by calculating prediction score nomogram....