A5100408222- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Macrophage Migration Inhibitory Factor
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immunotherapy and Immune Responses
- Crystal structures of chemical compounds
- Glutathione Transferases and Polymorphisms
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Porphyrin and Phthalocyanine Chemistry
- Advanced Drug Delivery Systems
- Electrolyte and hormonal disorders
- Microbial metabolism and enzyme function
- Structural Behavior of Reinforced Concrete
- Curcumin's Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Lung Cancer Research Studies
Chinese University of Hong Kong
2021-2024
Prince of Wales Hospital
2024
Nanjing Chest Hospital
2019-2024
Nanjing Medical University
2024
Nanjing Brain Hospital
2024
Soochow University
2022-2024
Second Affiliated Hospital of Soochow University
2022-2024
Inner Mongolia Agricultural University
2024
First Affiliated Hospital of Zhengzhou University
2023
Hebei Medical University
2023
Catalytic DNA molecules that target the transcription factor c- jun inhibit skin cancer growth in mice.
Background/Aims: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. However, molecular mechanisms regulating osteosarcoma tumorigenesis progression are still poorly understood. Circular RNAs (circRNAs) have been identified as microRNA sponges involved many important biological processes. This study aims to investigate global changes expression pattern of circRNAs provide a comprehensive understanding differentially expressed circRNAs. Methods:...
Abstract Background Circular RNAs (circRNAs) have recently been shown to play important roles in different tumors. However, their detailed and regulatory mechanisms pancreatic ductal adenocarcinoma (PDAC) are not well understood. This study aimed identify enriched circRNAs detect functions PDAC cells tissues. Methods circRNA-ASH2L (circ-ASH2L) was identified by circRNA microarray studies based on previous studies, further detected samples qRT-PCR. The of circ-ASH2L were transwell, EdU, cell...
Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. As a type CVDs, myocardial infarction (MI) induces ischemia hypoxia, which leads to excessive reactive oxygen species (ROS), resulting in multiple cell deaths and contributing subsequent development heart failure or premature death. Recent evidence indicates that ROS-induced lipid peroxidation promotes autophagy ferroptosis, loss healthy myocardium dysfunction cardiac tissue. Theoretically, function would be...
// Xiang Zhou 1 , Dimple Natino 2 Zili Qin 3 Dong Wang Zhen Tian 4 Xuan Cai Bo 5 and Xijing He Department of Orthopaedics, Second Affiliated Hospital Xi'an Jiaotong University, Xi'an, China Biomedical Sciences, Florida State University College Medicine, Tallahassee, FL, USA Otolaryngology, Otorhinolaryngology Hospital, The First Sun Yat-sen Guangzhou, Infectious Diseases, Pharmacology, School Basic Medical Science, Health Science Center, Correspondence to: He, email: xijing_h@vip.tom.com...
Aims Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development diverse diseases including osteonecrosis femoral head (ONFH). Here, we explored impact hsa_circ_0066523 derived from forkhead box P1 (FOXP1) (also called circFOXP1) on bone mesenchymal stem cells (BMSCs), which is important for ONFH development. Methods or protein expression BMSCs was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) western blot, respectively. Cell...
Circular RNAs (circRNAs) have been discovered to participate in the carcinogenesis of multiple cancers. However, role circRNAs esophageal squamous cell carcinoma (ESCC) progression is yet be properly understood. This research aimed investigate and understand mechanism used by regulate ESCC progression.Bioinformatics analysis was first performed screen dysregulated differentially expressed genes ESCC. The tissue samples adjacent normal utilized this study were obtained from 36 patients. All...
The dysfunctions of human umbilical vein endothelial cells (HUVECs) are important features atherosclerosis (AS). Circular RNAs (circRNAs) regulators a wide range diseases, including AS. present study aimed to investigate the role circUSP36 in ectopic phenotype HUVECs and provide evidence involvement pathogenesis AS cell models vitro were established using exposed oxidized low‑density lipoprotein (ox‑LDL). Cell viability, cycle progression apoptosis, migration invasion assessed by counting...
The circular RNA PRKCI (circ-PRKCI; ID: hsa_circ_0122683) is highly expressed in human papillary thyroid cancer (PTC) tumors according to GSE93522 dataset. However, its role PTC tumorigenesis remains be documented. Here, quantitative real-time PCR showed that expression of circ-PRKCI was abnormally upregulated patients' and cells, higher might predict lymph node metastasis recurrence. Functionally, cell behaviors were measured by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide...
Background: The lysyl oxidate-like (LOXL) family was reported to be involved in the process of cancer development. However, prognostic value LOXL lung is unknown. We aimed study expression pattern and members squamous cell carcinoma (LUSC). Methods: Wilcoxon test logistic regression analysis were used level LOXLs its correlation with clinical characteristics. Kaplan-Meier method Cox performed estimate LOXsL survival LUSC patients. Receiver operator characteristic (ROC) curves plotted, areas...
Circular RNAs (circRNAs) are abundantly expressed in cancer. Their resistance to exonucleases enables them have potentially stable interactions with different types of biomolecules. Alternative splicing can create circRNA isoforms that sequences and unequal interaction potentials. The study function thus requires knowledge complete sequences. Here we describe psirc, a method identify full-length quantify their expression levels from RNA sequencing data. We confirm the effectiveness...
Abstract Background Circular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression diverse kinds human cancers. In this study, we explored role hsa_circ_0000231 its downstream pathway in CRC. Methods The expression profile circRNAs 5 pairs CRC tissues adjacent normal were analyzed by Microarray. Quantitative real-time PCR situ hybridization Base Scope Assay used to determine level prognostic values . Then, functional experiments vitro vivo performed investigate...
Abstract Liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin) plays an important regulatory role in a variety of diseases, including tumors. However, the underlying mechanism LSECtin gastric cancer (GC) remains largely unknown. In our research, promoted adhesion invasion GC cells, was involved lymphatic metastasis cells. Mechanistically, adhesion, proliferation migration cells by downregulating STAT1 expression. The circular RNA circFBXL4, which is regulated LSECtin,...
Papillary thyroid cancer (PTC) is the most common endocrine malignant tumour. The purpose of this study was to explore potential molecular mechanism circRNA regulating immune-related mRNA through sponge miRNA in occurrence and immune regulation PTC.All data were downloaded from public databases, such as GEO, Immport TCGA. Differentially expressed (DE) mRNAs (DEmRNAs), DEmiRNAs DEcircRNAs identified using metaMA limma packages. Subsequently, DEmRNAs screened, circRNA-miRNA-mRNA (ceRNA)...
Abstract Background Growing evidence suggests that circular RNAs (circRNAs) are involved in the development of osteoarthritis (OA). The present study aimed to explore CircADAMTS6/miR‐431‐5p axis with respect regulating interleukin‐1β (IL‐1β) induced chondrocyte apoptosis. Methods We first evaluated differentially expressed circRNAs between normal chondrocytes and interleukin (IL)‐1β‐stimulated chondrocytes. Then, bioinformatic analysis was performed identify role function circADAMTS6. Small...
Objectives: Studies have demonstrated that genetic variants in the miRNA-coding genes might be associated with cancer susceptibility and survival. Here, we aimed to investigate influence of MIR3142HG single-nucleotide polymorphisms on individual’s patients’ prognosis glioma. Materials Methods: Six were genotyped by Agena MassARRAY iPLEX Gold assay among 529 glioma patients 502 healthy controls. Association risk for was analyzed logistic regression analysis Cox proportional hazards model,...
Endometrial carcinoma (EC) development is associated with dysregulated circular RNA profiles. The purpose of the current research to study role and mechanism hsa_circ_0001610 (circ_0001610) in EC progression.circ_0001610, microRNA (miR)-646, signal transducer activator transcription 3 (STAT3) expression levels were measured EC. Functional analyses performed using Cell Counting Kit-8, colony formation, transwell, wound healing, flow cytometry, glycolysis, xenograft analyses. Binding...
Abstract Packaging hydrophobic drugs into polysaccharide carriers can improve their aqueous solubility, biocompatibility, tumor‐specific accumulation, and therapeutic effect. In this work, phenylboronic acid (PBA) was anchored onto the chain of biocompatible hyaluronic (HA) by an amide condensation reaction, which could be used to fabricate stimuli‐responsive targeted drug delivery systems. A series pH‐responsive conjugated nanoparticles composed a core hydrophilic shell were prepared...
Abstract Glioma is the most common primary malignant intracranial tumor in humans, and glioblastoma (GBM) has been associated with a more aggressive histology poorer prognosis. There growing evidence that circular RNAs (circRNAs) are involved progression of various malignancies; however, role molecular mechanism circRNAs glioma remain elusive. In present study, we screened for differentially expressed gliomas by using bioinformatics method. Significant upregulation tissues was verified...