A5090414029- Acupuncture Treatment Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hepatocellular Carcinoma Treatment and Prognosis
- Lipoproteins and Cardiovascular Health
- MicroRNA in disease regulation
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Trace Elements in Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Myofascial pain diagnosis and treatment
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Health disparities and outcomes
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Chromium effects and bioremediation
- Traditional Chinese Medicine Studies
- Mechanisms of cancer metastasis
- Cholesterol and Lipid Metabolism
Chinese People's Liberation Army
2022-2025
Chinese PLA General Hospital
2022-2025
State Key Laboratory of Kidney Diseases
2022-2025
Chengdu University of Traditional Chinese Medicine
2025
Yuan's General Hospital
2024
Hubei University of Medicine
2022-2024
Qilu Hospital of Shandong University
2023-2024
First People's Hospital of Chongqing
2020-2023
Affiliated Hospital of North Sichuan Medical College
2022-2023
Shandong Agricultural University
2019-2022
Abstract Background The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed comprehensively assess the association between indicators and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), bradyarrhythmia UK Biobank cohort. Methods After excluding ineligible participants, a total 478,524 eligible individuals (46.75% male, aged 40–69 years) were enrolled study...
Accumulating evidence has suggested the importance of gut microbiota in development type 2 diabetes mellitus (T2DM). In present study, 40 patients with T2DM were treated liraglutide for 4 months. Feces samples and clinical characteristics collected from these before after treatment. The diversity composition two groups determined by sequencing V4 region bacterial 16S rRNA genes. Meanwhile, blood glucose, insulin, hemoglobin A1c (HbA1c), lipid metabolism also measured pre-...
To investigate the relationship among 18 heavy metals, microsatellite instability (MSI) status, ERCC1, XRCC1 (rs25487), BRAF V600E and 5 tumor markers their role in development of colorectal cancer (CRC).A total 101 CRC patients 60 healthy controls were recruited present study. The levels metals measured by ICP-MS. MSI status genetic polymorphism determined PCR (FP205-02, Tiangen Biochemical Technology Co., Ltd., Beijing, China) Sanger sequencing. Spearman's rank correlation was used to...
We examined the sequence of nervous system abnormalities that resulted when rats were given excess amounts vitamin B<sub>6</sub> (pyridoxine). High doses pyridoxine (1,200 or 600 mg/kg/d) for 6 to 10 days caused a neuronopathy with necrosis dorsal root ganglion (DRG) sensory neurons, accompanied by centrifugal axonal atrophy and breakdown peripheral central axons. Large diameter neurons long processes large cytoplasmic volumes especially affected. Smaller (300 150 up 12 weeks had minor...
Background The neutrophil-percentage-to-albumin ratio (NPAR), as a low-cost and easily accessible inflammatory biomarker, has garnered considerable attention in various disease studies recent years. Specifically, existing research suggested significant correlation between NPAR diabetic retinopathy, indicating its potential relevance to complications. However, despite kidney (DKD) being complication that severely affects the quality of life patients, association prevalence DKD remains be...
Coronary artery disease (CAD) is a worldwide leading cause of death. Considering that 20%-40% patients with CAD have long asymptomatic period atherosclerosis, it has become urgent to explore the feasibility diagnosing at an early stage. This observational, case-control study, total 489 consecutive and 75 non-CAD controls were recruited. The levels low-density lipoprotein subfractions (LDLC1-7) in serum measured by Quantimetrix Lipoprint LDL system. 18 trace elements (vanadium, chromium,...
(1) Background: the epigenetic mechanisms underlying progression from acute kidney injury (AKI) to chronic disease (CKD) remain poorly understood; (2) Methods: investigate this process, we conducted genome-wide DNA methylation sequencing map changes during AKI-CKD transition in a mouse model. By integrating methylome and transcriptome analyses, identified genes signaling pathways regulated by throughout progression; (3) Results: our analysis four candidate genes—Atp1a3, Ncf1, Lpl,...
Abstract Background Cancer is a major public health issue worldwide. The cost of cancer care imposes substantial economic burden on society and patient, but it has not been thoroughly studied in China. This study aimed to describe direct elements all types by different beneficial characteristics. Methods research was retrospective observational based inpatient outpatient records with primary diagnosis from 31 hospitals 2016. Total per time were analyzed type, sources (prescription medicines,...
Menopause is associated with dyslipidemia and an increased risk of cardiovascular disease, the underlying mechanism attributed to insufficiency estrogen. In this study, we find that estrogen mediates atherosclerotic-protective action via receptor alpha/SREBP-1 signaling. Increased lipid accumulation low-density lipoprotein (LDL)-uptake in HepG2 cells THP-1 macrophages were induced by treatment mixed hyperlipidemic serum from postmenopausal women; 17β-estradiol [estrogen (E2)] (10 nM)...
Objective: This study aims to explore the correlates of frailty in hospitalized elderly hypertensive patients and its impact on clinical prognosis, construct a predictive model for occurrence this population. Methods: A cross-sectional prospective observational cohort was conducted, involving 312 diagnosed at institution from January June 2022. Frailty using Fried Phenotype (FP), while Charlson Comorbidities Index (CCI) assessed presence chronic conditions. Data analysis performed SPSS 22.0....
Tanshinone IIA is the active compound isolated from Salvia miltiorrhiza bunge, which a traditional Chinese medicine known as Danshen. The aim of present study was to assess effect on regulation lipid metabolism in livers hyperlipidemic rats and underlying molecular events. An vivo model hyperlipidemia established rats, with animals receiving daily dose IIA. serum profiles were analyzed using an automatic biochemical analyzer, histopathological alterations deposition liver tissue assessed...
Purpose: The aim of this study was to verify the potential risk factors ventilator-associated pneumonia (VAP) in elderly Chinese patients receiving mechanical ventilation (MV). secondary present logistical regression prediction models VAP occurrence MV. Methods: Patients (aged 80 years or above) MV for ≥48 h were enrolled from People's Liberation Army (PLA) General Hospital January 2011 December 2015. A chi-squared test and Mann-Whitney U-test used compare data between participants with...
The gut microbiota plays an important role in the regulation of immune system and metabolism host. aim present study was to characterize patients with type 2 diabetes mellitus (T2DM). A total 118 participants newly diagnosed T2DM 89 control subjects were recruited study; six clinical parameters collected quantity 10 different types bacteria assessed fecal samples using quantitative PCR. Taking into consideration variables bacteria, 3 predictive models established training set test set,...
There is a high incidence of both smoking and tuberculosis (TB) in China. This study examined the risk factors for severe pulmonary TB (PTB) positive tubercle bacilli sputum.We conducted retrospective case-control tertiary hospital from January 2017 to December 2018 (n = 917). The clinical biological characteristics patients were collected, univariable multivariable logistic regression analyses performed assess associated with terms severity transmission PTB.Positive sputum PTB much higher...
This study aims to explore gut microbiota dysbiosis in the histological stages of gastric cancer (GC). Feces samples and clinical characteristics were collected from patients with different GC, including 15 superficial gastritis (SG), 13 atrophic (AG), 8 mucosal atypical hyperplasia (GMAH), advanced GC cases. The diversity composition among four groups determined by sequencing V4 region bacterial 16S rRNA genes. Reduced microbial alpha altered dissimilarity community structure found groups....
Abstract Liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin) plays an important regulatory role in a variety of diseases, including tumors. However, the underlying mechanism LSECtin gastric cancer (GC) remains largely unknown. In our research, promoted adhesion invasion GC cells, was involved lymphatic metastasis cells. Mechanistically, adhesion, proliferation migration cells by downregulating STAT1 expression. The circular RNA circFBXL4, which is regulated LSECtin,...
This study aimed to observe the relationship among heavy metals concentration, microsatellite instability (MSI), and human epidermal growth factor receptor type 2 (HER2) gene amplification in gastric cancer (GC) patients.The concentrations of 18 plasma GC patients healthy controls were measured by inductive coupled emission spectrometry (ICP-MS). MSI detection was conducted detecting 5 repeat markers PCR analysis. HER2 detected fluorescence situ hybridization (FISH). The metal elements,...
Purpose: This study aimed to explore whether Galangin (Gal) could improve cerebral Ischemia- reperfusion (I/R) injury by regulating astrocytes, and clarify its potential molecular mechanism. Methods: An I/R model of rats was established using the Middle Cerebral Artery Occlusion/Reperfusion (MCAO/R) method, followed administration Gal (25, 50, 100 mg/kg) via gavage for 14 consecutive days. Besides, astrocytes were isolated from construct an Oxygen-Glucose Deprivation/Re-oxygenation (OGD/R)...
To observe the clinical effect of acupuncture at lower-he acupoints and front-mu combined with Tongxieyaofang (TXYF) for diarrhea-type irritable bowel syndrome (IBS-D) liver depression spleen deficiency, to explore its possible mechanism.A total 123 IBS-D patients deficiency were randomly divided into an acupuncture+TXYF group, a TXYF group medication 41 cases in each group. The treated oral administration TXYF, three times day. routine Shangjuxu (ST 37), Tianshu 25), Taichong (LR 3),...