A5100354710- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Chemokine receptors and signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biomarkers in Disease Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cytokine Signaling Pathways and Interactions
- Advanced Biosensing Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Lipoproteins and Cardiovascular Health
- Nerve injury and regeneration
- Cancer-related Molecular Pathways
- Anesthesia and Neurotoxicity Research
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- T-cell and B-cell Immunology
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Single-cell and spatial transcriptomics
- Protein Tyrosine Phosphatases
Second Affiliated Hospital of Zhejiang University
2022-2024
Chinese PLA General Hospital
2022
Jilin University
2014-2021
First Hospital of Jilin University
2018-2021
Shanghai Jiao Tong University
2019
Immune Regulation (United Kingdom)
2017
University of Birmingham
2017
Zhongda Hospital Southeast University
2016
Virginia Commonwealth University
2014-2015
King's College London
2008
Abstract Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation lipid contents and chronic inflammation. Traditional strategies primarily focus on reduction to control AS progression, leaving residual inflammatory risks for major adverse cardiovascular events (MACEs). While anti-inflammatory therapies targeting innate immunity have reduced MACEs, many patients continue face significant risks. Another key component in progression...
Atherosclerosis is a progressive inflammatory disease and can develop in large arteries such as carotid femoral or medium-sized muscular of the heart. Previous predominantly experimental studies suggested an important role chemokines development atherosclerosis. The main aim this study was to examine potential effect CCR5-del32 mutation on systemic inflammation, intima-media thickness arteries, indices cardiovascular disease.In present study, we have examined association common functional...
Background: Chronic inflammation plays a critical role in the progression of atherosclerosis (AS). This study aimed to determine effects CXC chemokine ligand 16 (CXCL16)/CXC receptor 6 (CXCR6) pathway on cholesterol accumulation radial arteries end-stage renal disease (ESRD) patients with concomitant microinflammation and further investigate potential purinergic P2X ligand-gated ion channel 7 (P2X7R). Methods: Forty-three ESRD were divided into control group (n=17) inflamed (n=26) based...
Rationale: Pathogenesis of human coronary atherosclerosis is tightly associated with the imbalance inflammation and resolution in local immune microenvironment AS plaques.However, how peripheral system dynamically changes along disease progression humans remains unclear.As a result, minimally-invasive clinical biomarkers that can sensitively distinguish different stages are still lacking.Methods: We performed single-cell Cytometry by Time-Of-Flight (CyTOF) analyses to comprehensively profile...
PD0332991 (palbociclib/Ibrance®) is a cyclin-dependent kinase (CDK)4/6 inhibitor that has recently been approved for the treatment of estrogen receptor‑positive advanced breast cancer. The present study investigated antiproliferative effects on gastric cancer (GC) cells and underlying molecular mechanisms. activity was tested in several GC cell lines, including AGS, KATO‑Ⅲ, NCI‑N87 HS746T. Growth inhibitory PD0332991, alone or combination with fluorouracil (5‑FU), measured by MTT assay....
Postoperative cognitive dysfunction (POCD) is a prevalent neurocognitive disorder following surgery and anesthesia, particularly in elderly patients. Isoflurane widely used anesthetic agent, which associated with the development of POCD; however, precise mechanisms remain unclear. In present study, aged rats were exposed to 2% isoflurane establish POCD model. The expression PYRIN‑containing Apaf1‑like protein 1 (PYPAF1) was knocked down using lentivirus containing specific short hairpin RNA....
Atherosclerosis is the pathological basis of coronary artery disease (CAD) and causes high mortality. Thus, early detection thought to be crucial in reducing risk CAD. Uncovering mechanisms progression regression atherosclerosis will provide insights into discovering novel biomarkers identify subjects at for CAD improve prevention. We established a rabbit model. Then, we extracted mRNA abdominal aorta from control, model recovery groups perform gene chip analysis. Candidate were screened by...
Objective To investigate the potential role of CXC chemokine ligand 16 (CXCL16)/CXC receptor 6 (CXCR6) pathway in progression diabetic nephropathy (DN). Methods 8-week old male db/db mice were randomly divided into DN group and inflamed group. 10% casein was subcutaneously injected to induce mouse model with inflammation. In vitro, HK-2 cells treated high glucose (HG), IL-1β+ HG effect inflammatory stress on cells. Further knockdown CXCL16 mediated by RNA interference determine...
To investigate the antiatherosclerotic effects of flavonoids extracted from Apocynum venetum (AVF) leaves in atherosclerotic rats and underlying mechanisms, a total 72 male Wistar were randomly divided into six groups: control group, model simvastatin low-dose AVF medium-dose high-dose group. Atherosclerosis was induced with high-fat diet an intraperitoneal injection VD3 once daily for three contiguous days at dose 70 U/kg. At end 13th week, serum cholesterol (TC), triglyceride (TG),...
Recent studies have shown that Nlrp3 inflammasomes function as a major intracellular molecular machinery to switch on the inflammatory response upon sensing danger signals such elevated plasma levels of cholesterol during hypercholesterolemia (HC). The present study tested hypothesis endothelial inflammasome activation has uncanonical direct actions cells (ECs) producing dysfunction prior or inflammation, which contribute vascular injury at early stages atherogenesis. Endothelial was...
Nucleotide oligomerization domain (NOD)-like receptor protein with pyrin containing 3 (Nlrp3) inflammasome has been reported to be activated by atherogenic factors, thereby triggering endothelial injury and consequent atherosclerotic lesions in the arterial wall. However, mechanism activating regulating Nlrp3 inflammasomes remains poorly understood. The present study tested whether membrane raft (MR) signaling platforms associated acid sphingomyelinase (ASM) its product ceramide (Ce)...
Objective To investigate the effects of CXC chemokine ligand 16 (CXCL16)/CXC receptor 6 (CXCR6) pathway on cholesterol accumulation atherosclerosis in radial artery end-stage renal disease (ESRD) patients under inflammatory stress and further its potential mechanisms modulated by purinergic P2X ligand-gated ion channel 7 (P2X7R). Methods According to plasma C-reactive protein (CRP), forty ESRD were divided into control group (CRP<3.0 mg/L, n=15) inflammation (CRP≥3.0 n=25)....