A5003151460- Congenital limb and hand anomalies
- Distributed and Parallel Computing Systems
- Genetic and Kidney Cyst Diseases
- Glycogen Storage Diseases and Myoclonus
- Renal and Vascular Pathologies
- Genetic Syndromes and Imprinting
- Connective tissue disorders research
- Genetic Neurodegenerative Diseases
- Spinal Fractures and Fixation Techniques
- Neurological disorders and treatments
- Wnt/β-catenin signaling in development and cancer
- Biomedical Research and Pathophysiology
- Pediatric Hepatobiliary Diseases and Treatments
- Ion channel regulation and function
- Renal and related cancers
- Retinal Development and Disorders
- Neurological and metabolic disorders
- Hematological disorders and diagnostics
- Cardiac electrophysiology and arrhythmias
- RNA regulation and disease
- Dermatological and Skeletal Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Parallel Computing and Optimization Techniques
- Cloud Computing and Resource Management
Jinnah Postgraduate Medical Center
2017-2021
Bahria University
2020
AdventHealth Orlando
2018-2019
Liaquat National Hospital
2019
University of Central Florida
2018
Florida College
2018
Aga Khan University Hospital
2018
Feinstein Institute for Medical Research
2015
Alba Graduate Business School, The American College of Greece
2014
SUNY Downstate Health Sciences University
2014
Recent evidence indicates that vascular progenitor cells may be the source of smooth muscle (SMCs) accumulate in atherosclerotic lesions, but origin these is unknown. To explore possibility existing adults, a variety tissues from ApoE-deficient mice were extensively examined. Immunohistochemical staining revealed adventitia aortic roots harbored large numbers having stem cell markers, e.g., Sca-1+ (21%), c-kit+ (9%), CD34+ (15%), and Flk1+ (4%), not SSEA-1+ embryonic cells. Explanted...
Background— Accumulating evidence established a positive association of anti–heat shock protein 60 (HSP60) autoantibodies and the presence atherosclerosis in humans. However, whether these play causal role development is unknown. Methods Results— In present study, anti-HSP60 from blood patients with coronary heart disease were isolated by affinity chromatography injected into tail vein apolipoprotein E–deficient mice. Atherosclerotic lesions aortas significantly increased 8 weeks after...
Autosomal recessive Robinow syndrome (RRS) is a severe skeletal dysplasia with short stature, generalized limb shortening, segmental defects of the spine, brachydactyly, and dysmorphic facial appearance. The gene encoding receptor orphan tyrosine kinase 2 (ROR2) located on chromosome 9q22 homozygous loss-of-function mutations in this are responsible for RRS. Moreover, knocking out mouse Ror2 causes mesomelic dwarfism state, almost identical features to syndrome. protein product cell membrane...
Recent evidence indicates that vascular progenitor cells may be the source of smooth muscle (SMCs) accumulate in atherosclerotic lesions, but origin these is unknown. To explore possibility existing adults, a variety tissues from ApoE-deficient mice were extensively examined. Immunohistochemical staining revealed adventitia aortic roots harbored large numbers having stem cell markers, e.g., Sca-1+ (21%), c-kit+ (9%), CD34+ (15%), and Flk1+ (4%), not SSEA-1+ embryonic cells. Explanted...
Atherosclerosis is a progressive inflammatory disease and can develop in large arteries such as carotid femoral or medium-sized muscular of the heart. Previous predominantly experimental studies suggested an important role chemokines development atherosclerosis. The main aim this study was to examine potential effect CCR5-del32 mutation on systemic inflammation, intima-media thickness arteries, indices cardiovascular disease.In present study, we have examined association common functional...
Recurrent respiratory papillomatosis (RRP) is a rare, chronic disease caused by human papillomaviruses (HPVs) types 6 and 11 that characterized the polarization of adaptive immune responses support persistent HPV infection. Respiratory papillomas express elevated mRNA levels IL-36γ, proinflammatory cytokine in comparison to autologous clinically normal laryngeal tissues; however there no evidence inflammation these lesions. Consistent with this, do not contain TH1-like CD4+ T-cells or...
Traumatic intracerebral contusion is a frequent factor culminating in death and disability, its progression relates to unfavorable outcome. We evaluated the radiological factors associated with hemorrhagic of contusions (HPC).Two hundred forty-six patients were enrolled this prospective cohort over period 1 year. Contusion volume was quantified using "ABC/2" technique, whereas considered as >30% increase initial volume. Univariate multivariate statistics used examine correlation between risk...
<i>Background:</i> Atrial fibrillation (AF) is a common arrhythmia encountered following cardiac surgery. Previously, we have shown that higher expression of heat shock protein (HSP) 70 was associated with decreased incidence postoperative AF (PoAF), suggestive an antiarrhythmic role. <i>Objective:</i> We hypothesised Met493Thr substitution one the important <i>hsp</i>70 genes may cause loss these protective effects. therefore set out to examine influence...
To determine the risk factors, presentation and outcome of meningomyelocele repair.We reviewed 150 cases operated for (MMC) at Jinnah Postgraduate Medical Centre Karachi between May 2015 2018. Data infants MMC repair was extracted including socioeconomic status, maternal folate intake during pregnancy, head circumference, location width defect, accompanying bladder limb anomalies treatments administered. Patients were followed up a mean period six months.A total children evaluated, out which...
To determine the impact of helmet wearing on traumatic brain injury.We analyzed 400 cases injury (TBI) in motorbike riders with and without helmet, from July 2017 to December 2020 presenting neurosurgery department at Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan. The medical records were for CT scan findings, length hospital stay, complications (mortality disability), Glasgow Coma Scale (GCS) outcome score (GOS) time discharge.A total patients head due accidents included all...
Long-QT syndrome is a monogenic disorder that produces cardiac arrhythmias and can lead to sudden death. At least 5 loci 4 known genes exist in which mutations have been shown be responsible for the disease. The potassium channel gene KCNQ1, previously named KVLQT1, on chromosome 11p15.5 one of these.We initially analyzed family using microsatellite markers found linkage KCNQ1. Mutation detection showed G C change last base exon 6 (1032 G-->C) does not alter coded alanine. Restriction digest...
Human Papillomaviruses (HPVs) 6 and 11 are part of a large family small DNA viruses, some which commensal. Although much the population can contain or clear infection with these there is subset individuals who develop persistent that cause significant morbidity on occasion mortality. Depending site infection, patients chronically infected viruses either recurrent, occasion, severe genital warts recurrent respiratory papillomas obstruct upper airway. The HPV-induced diseases described likely...
Diffuse axonal injury (DAI) is a common presentation in neurotrauma. Prognosis variable but can be dependent on the initial of patient. In our study, we evaluated outcome diffuse injury.This study was conducted at tertiary care center from September 2018 to December 2019 and included 133 adult patients with moderate or severe head (GCS ≤ 12) diagnosed have DAI basis MRI. At 3 months, result assessed using Extended Glasgow Outcome Scale (GOS-E).There were total 97 (72.9%) males 36 (27.1%)...
To assess outcomes in surgically managed patients with depressed skull fractures and associated moderate to severe head injury.The study was conducted the Department of Neurosurgery Jinnah Postgraduate Medical Centre, Karachi, from January 2016 December 2017. We analyzed 90 fracture 2015 2016. The selected for this belonged all age groups clinically palpable confirmed by CT brain bone window. Outcome assessed Glasgow outcome score.Total were included study. Sixty (66.7%) male 30 (33.3%)...
Grid computing infrastructures are inherently dynamic and unpredictable environments shared by many users. schedulers aim to make efficient use of grid resources while providing the best possible performance applications satisfying associated policy constraints. Additionally, in commercial settings, where resource brokering becomes an increasingly important part scheduling, it is necessary minimise cost application execution on behalf users, ensuring that meet their QoS Efficient allocation...