A5019986276- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Mitochondrial Function and Pathology
- Acute Myocardial Infarction Research
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Cardiac Valve Diseases and Treatments
- Mesenchymal stem cell research
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Peripheral Artery Disease Management
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Tissue Engineering and Regenerative Medicine
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Gastric Cancer Management and Outcomes
Second Affiliated Hospital of Zhejiang University
2015-2025
Anhui Medical University
2022-2025
Zhejiang University
2012-2025
Tianjin Medical University Cancer Institute and Hospital
2024
Nanjing University
2024
Sir Run Run Shaw Hospital
2009-2021
Nanjing Agricultural University
2021
Guangdong Provincial People's Hospital
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
In patients with coronary artery disease who are being evaluated for percutaneous intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) decision making regarding revascularization and stent implantation. However, the differences in clinical outcomes when only one method is used both purposes unclear.We randomly assigned 1682 were PCI treatment of intermediate stenosis (40 to 70% occlusion visual estimation on angiography) a 1:1...
A recent randomised trial demonstrated fractional flow reserve (FFR) guidance for percutaneous coronary intervention (PCI) was non-inferior to intravascular ultrasound (IVUS) regarding clinical outcomes, with a lower frequency of PCI. We sought evaluate the prognosis FFR versus IVUS PCI intermediate artery stenosis and low lesion complexity in diabetic non-diabetic patients. This study is prespecified post hoc analysis from FLAVOUR trial. The primary outcome major adverse cardiac events...
Human pluripotent stem cell-derived cardiovascular progenitor cells (hPSC-CVPCs) should be thoroughly investigated in large animal studies before testing clinical trials.The main of this study is to clarify whether hPSC-CVPCs can engraft for long time the heart primates after myocardial infarction (MI) and compare effectiveness safety immunosuppression with cyclosporine alone or multiple-drug regimen (MDR) containing cyclosporine, methylprednisolone, basiliximab cynomolgus monkeys that had...
Heart failure (HF) is among the leading causes of morbidity and mortality, its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) a master regulator that governs DNA damage response RNAPII (RNA polymerase II) pausing pathway, but role in HF pathogenesis incompletely understood. We assessed expression human nonhuman primate mouse models. To study function heart, we generated global cardiac-specific knockout mice. acutely abolished mature cardiomyocytes by...
Mitochondria are important cellular organelles and play essential roles in maintaining cell structure function. Emerging evidence indicates that addition to having proinflammatory proapoptotic effects, TNFα (tumor necrosis factor α) can, under certain circumstances, promote improvements mitochondrial integrity function, phenomena can be ascribed the existence of TNFR2 (TNFα receptor 2).The present study aimed investigate whether how activation mediates effects on mitochondria.Freshly...
Purpose To unravel the oncogenic role of CDCA4 in different cancers from perspective tumor immunity. Methods Raw data on expression samples and paracancerous were obtained TCGA GTEX databases. In addition, we investigated pathological stages survival analysis pan-cancer across Gene Expression Profiling Interactive Analysis (GEPIA) database. Cox Proportional Hazards Model shows that high levels are associated with several vital indicators oncology. On one hand, explored correlation between...
Objective— Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose this study was determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms MC stabilizer prevents pathological process. Approach Results— Nicotine administration increased size atherosclerotic lesions in apolipoprotein E–deficient ( Apoe −/− ) mice fed a...
The causative relationship between specific mitochondrial molecular structure and reactive oxygen species (ROS) generation has attracted much attention. NDUFA13 is a newly identified accessory subunit of mitochondria complex I with unique location that very close to the subunits low electrochemical potentials. It been reported down-regulated rendered tumor cells more resistant apoptosis. Thus, this molecule might provide an ideal opportunity for us investigate profile ROS its role in cell...
Mutagenesis screening is a powerful forward genetic approach that has been successfully applied in lower-model organisms to discover factors for biological processes. This phenotype-based yet be established vertebrates probing major human diseases, largely because of the complexity colony management. Herein, we report rapid strategy identifying modifiers cardiomyopathy (CM). Based on application doxorubicin stress zebrafish insertional cardiac (ZIC) mutants, identified 4 candidate...
Abstract An active host adaptive response is characterized by the existence of programmed cell death protein 1 (PD‐1) + /IFN‐γ cytotoxic T cells and IFN‐γ‐induced PD‐L1 tumor (TCs), which predicts high rate to anti‐PD‐1/L1 therapy. Recently, CD161 its ligand LLT1 (CLEC2D) have been identified as an emerging checkpoint for immunotherapy. Clarifying heterogeneous clinical expression pattern immune landscape a prerequisite maximizing blockade therapy in specific population oral squamous...
Drug resistance, either intrinsic or acquired, can impair treatment effects and result in increased cell motility death. MicroRNA-21 (miR-21), a proto-oncogene, may facilitate the development maintenance of drug resistance cancer cells. Restoring sensitivity improve therapeutic strategies, possibility that requires functional evaluation mechanistic exploration. For miR-21 detection, matched tissue samples from 30 head neck squamous carcinoma (HNSCC) patients 8 (HNC) lines were obtained....
<b><i>Objective:</i></b> We aimed to assess the ideal cut-off value of minimal lumen area (MLA) by intravascular ultrasound (IVUS) and its diagnostic performance predict ischemia, using a large-scale, pooled analysis. <b><i>Methods:</i></b> Eleven centers worldwide were invited provide their clinical, IVUS fractional flow reserve (FFR) data. A total 881 lesions enrolled. <b><i>Results:</i></b> Angiographic % diameter...
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The Fractional Flow Reserve and Intravascular Ultrasound-Guided Intervention Strategy for Clinical Outcomes in Patients with Intermediate Stenosis (FLAVOUR) trial demonstrated non-inferiority of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared intravascular ultrasound (IVUS)-guided PCI. We sought to investigate the cost-effectiveness FFR-guided PCI IVUS-guided Korea.
Efficacy of combined intravascular ultrasound (IVUS) parameters in functional significance prediction and discrepancy between IVUS fractional flow reserve (FFR) have not been well defined. This study therefore aimed to: 1) evaluate the diagnostic accuracy parameters, namely minimal lumen area (MLA) percent plaque burden (%PB), coronary artery stenosis; 2) define factors that affect relation FFR value parameters.At 11 international centres, measurements were concurrently performed 945 major...
Rationale: Pathogenesis of human coronary atherosclerosis is tightly associated with the imbalance inflammation and resolution in local immune microenvironment AS plaques.However, how peripheral system dynamically changes along disease progression humans remains unclear.As a result, minimally-invasive clinical biomarkers that can sensitively distinguish different stages are still lacking.Methods: We performed single-cell Cytometry by Time-Of-Flight (CyTOF) analyses to comprehensively profile...