A5068241026- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Acute Myocardial Infarction Research
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Aortic Disease and Treatment Approaches
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Valve Diseases and Treatments
- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Cerebrospinal fluid and hydrocephalus
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Hip and Femur Fractures
- Lattice Boltzmann Simulation Studies
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
Ministry of Education
2025
Southwest Jiaotong University
2025
Huashan Hospital
2022
Fudan University
2022
Sun Yat-sen University
2009-2021
The First Affiliated Hospital, Sun Yat-sen University
2009-2021
Changsha University of Science and Technology
2017-2019
Umbo Computer Vision (United Kingdom)
2019
Linyi People's Hospital
2018
University at Buffalo, State University of New York
2009-2017
the purpose of this study was to identify significant morphological and hemodynamic parameters that discriminate intracranial aneurysm rupture status using 3-dimensional angiography computational fluid dynamics.one hundred nineteen aneurysms (38 ruptured, 81 unruptured) were analyzed from angiographic images dynamics. Six 7 evaluated for significance with respect rupture. Receiver operating characteristic analysis identified area under curve (AUC) optimal thresholds separating ruptured...
Background and Purpose— Hemodynamic insult by bilateral common carotid artery ligation has been shown to induce aneurysmal remodeling at the basilar terminus in a rabbit model. To characterize critical hemodynamics that initiate this remodeling, we applied novel hemodynamics–histology comapping technique. Methods— Eight rabbits received increase flow. Three underwent sham operations. was assessed computational fluid dynamics. Bifurcation tissue harvested on day 5; histology comapped with...
Additive manufacturing (3D printing) technology offers a great opportunity towards development of patient-specific vascular anatomic models, for medical device testing and physiological condition evaluation. However, the process is not yet well established there are various limitations depending on printing materials, printer resolution. Patient-specific neuro-vascular anatomy was acquired from computed tomography angiography rotational digital subtraction (DSA). The volumes were imported...
The aim of this study was to quantify the effect new Low-profile Visualized Intraluminal Support (LVIS®D) device and difference fluid diverting compared with Pipeline Enterprise stent using computational dynamics (CFD).In research, we simulated three aneurysms constructed from 3D digital subtraction angiography (DSA). Enterprise, LVIS were virtually conformed fit into vessel lumen placed across aneurysm orifice. Computational analysis performed compare hemodynamic differences such as WSS,...
Stimulated by a recent controversy regarding pressure drops predicted in giant aneurysm with proximal stenosis, the present study sought to assess variability prediction of pressures and flow wide variety research groups. In phase I, lumen geometry, rates, fluid properties were specified, leaving each group choose their solver, discretization, solution strategies. Variability was assessed having interpolate results onto standardized mesh centerline. For II, physical model geometry...
Objective Computational fluid dynamics (CFD) simulations of intracranial aneurysm hemodynamics usually adopt the simplification Newtonian blood rheology model. A study was undertaken to examine whether such a model affects predicted in realistic geometries. Methods Pulsatile CFD were carried out using viscosity and two non-Newtonian models (Casson Herschel-Bulkley) three typical internal carotid artery saccular aneurysms (A, sidewall, oblong-shaped with daughter sac; B, quasi-spherical; C,...
With the increased availability of computational resources, past decade has seen a rise in use fluid dynamics (CFD) for medical applications. There been an increase application CFD to attempt predict rupture intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, date, no consistent methodology prediction identified. One particular challenge is that factors contribute its accuracy; mesh resolution and spatial/temporal discretization alone...
This study developed a human acellular nerve graft (hANG) as an alternative to autogenous and reports on its safety efficacy. There were two groups comprised of 72 patients that received digital repair with hANG (test) 81 conventional direct tension-free suture the defect (control). The efficacy treatment was evaluated by static 2-point discrimination (s2PD) Semmes-Weinstein monofilament testing. Safety local wound response laboratory Mean age in test group 33.0 ± 11.1 years (range 18-61...
To assess the diagnostic accuracy of AccuIMR, a newly proposed, pressure wire-free index, in identifying coronary microvascular dysfunction (CMD) among patients with acute syndrome [including ST-segment elevation myocardial infarction (STEMI) and non-ST-segment (NSTEMI)] chronic (CCS).A total 163 consecutive (43 STEMI, 59 NSTEMI, 61 CCS), who underwent invasive angiography (ICA) for whom index microcirculatory resistance (IMR) was measured, were retrospectively enrolled at single center. IMR...
The index of microcirculatory resistance is a reliable measure for evaluating coronary microvasculature, but its prognostic value in patients with non–ST-segment elevation myocardial infarction (NSTEMI) remains unclear. This study aimed to evaluate the impact post–percutaneous intervention (PCI) angiography-derived (angio-IMR) NSTEMI. culprit vessel's angio-IMR was measured after PCI 2,212 NSTEMI at 3 sites. primary endpoint 2-year major adverse cardiac events (MACEs), defined as composite...
Flow diversion via Pipeline Embolization Device (PED) represents the most recent advancement in endovascular therapy of intracranial aneurysms. This exploratory study aims at a proof concept for an advanced device-modeling tool conjunction with computational fluid dynamics (CFD) to evaluate flow modification effects by PED actual, treated cases.The authors performed modeling 3 PED-treated complex aneurysm cases. The patient Case 1 had fusiform vertebral single PED. In 2 giant internal...
We have previously developed three logistic regression models for discriminating intracranial aneurysm rupture status from 119 aneurysms based on hemodynamic-morphological parameters. In this study we exploit their use as a tool predicting the risk of with defined Rupture Resemblance Score (RRS).We collected three-dimensional images 85 consecutive aneurysms, applied and compared model performance at against anecdotal metrics (aneurysm size aspect ratio). then reinterpreted model-predicted...
Background We previously established three logistic regression models for discriminating intracranial aneurysm rupture status based on morphological and hemodynamic analysis of 119 aneurysms. In this study, we tested if these would remain stable with increasing sample size, investigated sizes required various confidence levels (CIs). Methods augmented our previous dataset aneurysms into a new 204 samples by collecting an additional 85 consecutive aneurysms, which performed flow simulation...
A neurovascular flow diverter (FD), aiming at inducing embolic occlusion of cerebral aneurysms through hemodynamic changes, can produce variable mesh densities owing to its flexible structure.To explore whether the outcome would differ by increasing FD local compaction across aneurysm orifice.We investigated deployment a single using 2 clinical strategies: no (the standard method) and maximum orifice (an emerging strategy). Using an advanced modeling technique, we simulated these strategies...
The metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA) gene. However, little known about the pathological role of lncRNA MALAT1 in glioma. In present study, we explored expression level primary glioma tissues as well U87 and U251 cell lines. Using qRT-PCR, found that was significantly increased compared with paracancerous tissues. Meanwhile, expressed U98 cells. order to explore function MALAT1, greatly reduced cells...
Previous studies suggest that it may be inappropriate to determine treatment strategies solely based on the degree of stenosis for patients with intracranial atherosclerotic (ICAS). In order better risk stratify ICAS, we developed a novel non-invasive fractional flow (FF) calculation technique angiography (Angio-FF) assess hemodynamics ICAS. This study aims investigate difference in FF between symptomatic and asymptomatic ICAS its potential optimal threshold.
BackgroundThe assessment of coronary function and microcirculation in patients with ST-segment elevation myocardial infarction (STEMI) may be useful to guide long-term prognosis, but the research is limited. This study aimed investigate value angio-based fraction flow reserve (AccuFFR) an index microcirculatory resistance (AccuIMR) after percutaneous intervention (PCI) for evaluating prognosis STEMI patients.MethodsData who underwent PCI at Peking University Third Hospital between January...
Although aramid nanofibers (ANFs) consist of rigid poly(terephthalic acid terephthalamide) molecular chains with good high temperature resistance for aerospace and other high-temperature applications, it has poor electrical insulation properties due to internal defects. Currently, the main method improve is introduce wide band gap two-dimensional (2D) fillers, such as Boron Nitride Nanosheets (BNNS) or mica flakes, but this inevitably affects mechanical optical transparency. Cellulose...
The selection of fractional flow reserve derived from computed tomography (CT-FFR) calculation locations is particular importance when determining ischemic lesions for guiding therapeutic strategies. However, to date, there has been no prospective research comparing different measured CT-FFR. study aimed prospectively compare the diagnostic efficiency three interpretation methods CT-FFR, using invasive (FFR) as reference standard. Patients with stable coronary heart disease (CHD) who...