A5046588182- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Aortic aneurysm repair treatments
- Sleep and related disorders
- Micro and Nano Robotics
- Lattice Boltzmann Simulation Studies
- Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Moyamoya disease diagnosis and treatment
- Immune responses and vaccinations
- MicroRNA in disease regulation
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Aortic Disease and Treatment Approaches
- Intracerebral and Subarachnoid Hemorrhage Research
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Enhanced Oil Recovery Techniques
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
Philips (United States)
2024-2025
Jacobs (United States)
2025
Philips (Finland)
2024
University at Buffalo, State University of New York
2013-2021
Canon (United States)
2020
Toshiba (Japan)
2015-2017
Toshiba (United States)
2015-2017
Flow diversion via Pipeline Embolization Device (PED) represents the most recent advancement in endovascular therapy of intracranial aneurysms. This exploratory study aims at a proof concept for an advanced device-modeling tool conjunction with computational fluid dynamics (CFD) to evaluate flow modification effects by PED actual, treated cases.The authors performed modeling 3 PED-treated complex aneurysm cases. The patient Case 1 had fusiform vertebral single PED. In 2 giant internal...
Locally compacting the mesh of a flow diverter by dynamic push-pull technique can accelerate intracranial aneurysm healing. We asked how this deployment strategy compares with overlapping 2 diverters for aneurysmal reduction.Using high-fidelity virtual stent placement method, we simulated 3 flow-diverter strategies (single noncompacted, overlapped, and single compacted) in aneurysms (fusiform, large saccular, medium saccular). Computational fluid dynamics analysis provided posttreatment...
Recurrence of intracranial aneurysms after endovascular coiling is a serious clinical concern.We hypothesized that recurrence associated with aneurysm morphology and flow, as well the coil intervention induced flow modifications.We collected 52 primary-coiling cases were either occluded (n=34) or recurrent (n=18) at >1 year follow-up. We created models from pre-coiling digital subtraction angiographic images, calculated morphology, simulated hemodynamics, modeled deployment, obtained...
Inadequate sleep has been associated with an increased risk of mortality and various health issues. We previously conducted a placebo-controlled vaccination trial healthy adults who were monitored by blood samples, questionnaires, wearable devices. C-reactive protein (CRP), systemic marker inflammation, linked to numerous outcomes, was found significantly increase post-vaccination in the trial. In this retrospective study, we investigated that if inflammation response triggered perturbations...
<title>Abstract</title> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID, a chronic multisystemic condition with diverse symptoms and no objective diagnostic test. In this study, we developed data-driven method objectively detect persistent physiological changes post-COVID-19 using wearable device data. We analyzed data from 663 symptomatic COVID-19-positive cases 2,513 asymptomatic COVID-19-negative...
Computational fluid dynamics (CFD) is a promising tool to aid in clinical diagnoses of cardiovascular diseases. However, it uses assumptions that simplify the complexities real flow. Due high-stakes setting, critical calculate effect these CFD simulation results. existing validation approaches do not quantify error results due solver's modeling assumptions. Instead, they directly compare against data. Thus, accuracy solver, we developed methodology calculates model (arising from...
Treatment of intracranial aneurysms (IAs) has been revolutionized by the advent endovascular Flow Diverters (FDs), which disrupt blood flow within aneurysm to induce pro-thrombotic conditions, and serves as a scaffold for endothelial ingrowth arterial remodeling. Despite good clinical success FDs, complications like incomplete occlusion post-treatment rupture leading subarachnoid hemorrhage have reported. In silico computational fluid dynamic analysis pre- post-treated geometries IA patients...
Incompletely occluded flow diverter treated aneurysms remain at risk of rupture and thromboembolic complications. Our aim was to identify the potential for incomplete occlusion intracranial by diverters. We investigated whether aneurysm ostium size in relation parent artery affects angiographic outcomes diverter-treated sidewall aneurysms.Flow were divided into "occluded" "residual" (incomplete occlusion) groups based on 6-month follow-up. calculated ratio, a new parameter defined as surface...
Background Computer modeling of endovascular coiling intervention for intracranial aneurysm could enable a priori patient-specific treatment evaluation. To that end, we previously developed finite element method (FEM) technique, which incorporated simplified assumptions. improve accuracy in capturing real-life coiling, aimed to enhance the strategies and experimentally test whether improvements lead more accurate simulations. Methods We modeled coils using pre-shape based on mathematical...
Recent studies show that placement of neurovascular stents during treatment procedure plays a vital role in modifying the hemodynamics aneurysm sac and parent vessel. This study proposes an improved fast virtual stenting method for stent deployment, which can be used planning by comparing different strategies. is built upon FVS[1] Larrabide et al., expands within blood vessel providing artificial mathematical forces. Current incorporates two innovations: initialization advanced collision...
Endovascular treatment of intracranial aneurysms (IAs) by flow diverter (FD) stents depends on modification. Patient-specific modeling FD deployment and computational fluid dynamics (CFD) could enable a priori endovascular strategy optimization. We developed fast, simplistic, expansion-free balls-weeping algorithm to model FDs in patientspecific aneurysm geometry. However, since such strong simplification result less accurate simulations, we also fast virtual stenting workflow (VSW) that...
Enodvascular coils treat intracranial aneurysms (IAs) by causing them to occlude thrombosis. Ideally, coiled IAs eventually in the long-term. However, 20.8% are found incompletely occluded at treatment follow-up. Computer simulations of coiling and its effect on aneurysmal flow could help clinicians predict outcomes a priori, but it requires accurate modeling their deployment procedure. In addition being accurate, must be efficient used as bedside tool. To date, several virtual techniques...
A new realistic finite element method (FEM) based endovascular coil deployment technique was developed to explore the hemodynamic modifications of coiling in addition flow diverter (FD) treatment. patient-specific internal carotid artery aneurysm used as a test case, and single deployed using previously [1], along with several coils method. Results showed fluctuations parameters at low packing densities (1–3 coils) which are unexpected. At high density however (6 coils), results were...
<title>Abstract</title> Inadequate sleep has been associated with an increased risk of mortality and various health issues, but the role metrics from wearables in public remains unclear. C-reactive protein (CRP), a systemic marker inflammation, linked to numerous outcomes. We hypothesized that duration is inflammation response triggered by experimental interventions. studied 195 healthy adults, aged 18–40 years, placebo-controlled intervention vaccination trial. The participant’s was...
We employed computational fluid dynamics (CFD) and finite element method (FEM) to investigate the hemodynamic effect of two flow-diversion strategies cerebral aneurysm treatment: overlapping stents dense compaction a single stent. Three representative patient-specific aneurysms were used as test cases, flow diverters virtually deployed into models. Aneurysmal modification by is strongly correlated with metal coverage rate across neck, not uniquely determined FD deployment strategies....