A5018116961- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiac and Coronary Surgery Techniques
- Ultrasound and Hyperthermia Applications
- Adipose Tissue and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Aortic aneurysm repair treatments
- Genetic Associations and Epidemiology
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
Zhejiang University
2022-2025
Second Affiliated Hospital of Zhejiang University
2022-2025
Abstract Context Observational studies have suggested associations between adipokines and cardiovascular disease (CVD), but the roles of certain remain controversial, these not yet been ascertained causally. Objective To investigate whether circulating causally affect risk CVD using 2-sample Mendelian randomization (MR). Methods Independent genetic variants strongly associated with adiponectin, resistin, chemerin, retinol binding protein 4 (RBP4) were selected from public genome-wide...
Transcatheter aortic valve implantation (TAVI) might be a feasible treatment option for more patients with bicuspid (BAV) stenosis. However, long-term follow-up data in this population are scarce.The aim of study was to evaluate three-year outcomes after TAVI BAV.A total 246 consecutive who underwent at single centre China between March 2013 and February 2018 were enrolled study. Clinical outcomes, health status echocardiography followed recorded three years.Among 109 (44.3%) BAV patients,...
The index of microcirculatory resistance is a reliable measure for evaluating coronary microvasculature, but its prognostic value in patients with non–ST-segment elevation myocardial infarction (NSTEMI) remains unclear. This study aimed to evaluate the impact post–percutaneous intervention (PCI) angiography-derived (angio-IMR) NSTEMI. culprit vessel's angio-IMR was measured after PCI 2,212 NSTEMI at 3 sites. primary endpoint 2-year major adverse cardiac events (MACEs), defined as composite...
Few centers routinely report aortic arch calcification (AAC) due to the lack of an easy and effective evaluation method. The association between AAC clinical prognosis patients who undergo transcatheter valve replacement (TAVR) is unclear. We aimed develop a rapid method evaluate in underwent TAVR further assess their prognosis. enrolled 464 consecutive with stenosis TAVR. Patients severe (11.2%), moderate (18.5%), mild (58.2%), no (12.1%) had estimated 3-year all-cause mortality incidence...
Abstract Objectives We aimed to validate a novel staging system for aortic stenosis (AS) in Chinese patient cohort undergoing transcatheter valve replacement (TAVR), and compare this classification the traditional Society of Thoracic Surgeons (STS) score TAVR risk stratification. Background A AS based on extent cardiac damage upon echocardiography was recently proposed. Methods Patients were prospectively enrolled into Transcatheter Aortic Valve Replacement Single Center Registry Population...
Repositionable self-expanding valves allow for repositioning during deployment to achieve optimal valve placement. However, the risk of brain injury associated with repositioning, as detected by diffusion-weighted magnetic resonance imaging (DW-MRI), is unknown. Consecutive patients undergoing transcatheter aortic replacement (TAVR) repositionable and receiving DW-MRI before within 7 days post-TAVR procedure were included. The primary outcomes incidence, number, total volume, volume per...
Diabetes mellitus (DM) and coronary microvascular dysfunction (CMD) increase the risk of adverse cardiac events in patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to evaluate combined estimates DM CMD, assessed by angiography-derived index microcirculatory resistance (angio-IMR), NSTEMI. A total 2212 NSTEMI who underwent successful percutaneous intervention (PCI) were retrospectively enrolled from three centers. The primary outcome was a composite...
This research aimed to assess the impact of ticagrelor and clopidogrel on coronary microvascular dysfunction (CMD) prognosis following acute myocardial infarction (AMI), using angiography-derived index microcirculatory resistance (angio-IMR) as a non-invasive assessment tool. In this retrospective study, angio-IMR was performed evaluate CMD before after dual antiplatelet therapy (DAPT) with either (90 mg twice daily, n = 184) or (75 once 72). The primary endpoint is improvement evaluated by...
Background: Comparative data of the Valve Academic Research Consortium (VARC-3)-defined technical success between bicuspid versus tricuspid aortic stenosis (AS) remain lacking. Aims: We sought to compare and other clinical outcomes patients with AS receiving transcatheter valve replacement. Methods: A registration-based analysis was performed for 402 (211 191 cases AS, respectively). The primary outcome VARC-3-defined success. Additional assess up one year two groups. Results: Bicuspid...
Abstract Objectives To evaluate the feasibility of self‐expanding transcatheter aortic valve replacement (TAVR) in patients with stenosis and extremely horizontal aortas (aortic angulation ≥70°). Background As TAVR using a prosthesis is an off‐label treatment for aortas, these are often excluded from randomized controlled trials involving TAVR. Methods This study enrolled 27 consecutive who underwent severe stenosis. Results The patients' average age was 76.4 years, median Society Thoracic...
Transcatheter aortic valve replacement (TAVR) is not the preferred therapy for pure regurgitation (AR). Extremely horizontal aorta (aorta root angle ≥70°) regarded as an "off-label" use in self-expanding TAVR. This case series enrolled 7 consecutive AR patients who had extremely and underwent TAVR from TORCH registry. To best of our knowledge, this first study to report successful with aorta, revealing feasibility both transapical transfemoral challenging population.
Evidence for transcatheter aortic valve implantation (TAVI) is scarce among patients with non-calcific stenosis, and it not known whether calcification associated new cerebral ischemic lesions (CILs) that are detected by diffusion-weighted magnetic resonance imaging. So, our study enrolled 328 who underwent transfemoral TAVI using a self-expanding between December 2016 June 2021 from the TORCH registry (NCT02803294). A total of 34 were finally confirmed as AS remaining 294 included in...
Graphical Abstract.
Coronary occlusion is an uncommon but fatal complication of transcatheter aortic valve replacement (TAVR) with a poor prognosis. A patient symptomatic severe bicuspid stenosis was admitted to high-volume center specializing in transfemoral TAVR self-expanding valves. No anatomical risk factors coronary were identified on pre-procedural computed tomography analysis. The scheduled for valve. Balloon pre-dilatation prior prosthesis implantation routinely used assessing the supra-annular...