A5014999194- DNA Repair Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- PARP inhibition in cancer therapy
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- RNA regulation and disease
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Ubiquitin and proteasome pathways
- Sleep and Wakefulness Research
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Viral Infections and Immunology Research
- Aldose Reductase and Taurine
- Protein Degradation and Inhibitors
- Neuroscience and Neuropharmacology Research
Guangdong Pharmaceutical University
2024
Shenzhen University Health Science Center
2021-2023
Shenzhen University
2023
University of Hong Kong
2023
Academic Degrees & Graduate Education
2022
Shanghai Jiao Tong University
2019-2021
XinHua Hospital
2019-2021
Heart failure (HF) is among the leading causes of morbidity and mortality, its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) a master regulator that governs DNA damage response RNAPII (RNA polymerase II) pausing pathway, but role in HF pathogenesis incompletely understood. We assessed expression human nonhuman primate mouse models. To study function heart, we generated global cardiac-specific knockout mice. acutely abolished mature cardiomyocytes by...
The nephrotoxicity of Fructus Psoraleae, an effective traditional Chinese medicine for vitiligo treatment, has been reported. As one the main toxic components in bavachin (BV) was considered to be related Psoraleae-caused adverse outcomes, but direct evidence and molecular mechanism underlying BV-induced are not well elucidated. Therefore, this study designed confirm whether BV would cause effects on kidney explore possible mode action. Our results demonstrated that days' treatment with 0.5...
Post-traumatic stress disorder (PTSD) refers to a chronic impairing psychiatric occurring after exposure the severe traumatic event. Studies have demonstrated that medicinal cannabis oil plays an important role in neuroprotection, but mechanism by which it exerts anti-PTSD effects remains unclear. The complex (CCS) simulating conditions of long voyage for 4 weeks was used establish PTSD mice model. After that, behavioral tests were evaluate PTSD-like behaviors mice. Mouse brain tissue index...
Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) arrest cell cycle. However, it remains ambiguous whether how their E3 ligase activity regulates HR. Here, we demonstrate upon genotoxic stress, BRCA1 together with BARD1 catalyzes K48 polyubiquitination on LARP7, a 7SK RNA binding protein known control RNAPII pausing, thereby degrades through 26S ubiquitin-proteasome pathway....
Cell behaviors are dictated by epigenetic and transcriptional programs. Little is known about how extracellular stimuli modulate these programs to reshape gene expression control cell behavioral responses. Here, we interrogated the response of endothelial cells VEGFA treatment found rapid chromatin changes that mediate broad transcriptomic alterations. VEGFA-responsive genes were associated with active promoters, but in promoter histone marks not tightly linked changes. altered transcription...
Abstract The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs already differentiated cells remains exclusive. By profiling landscape endothelial VEGFA (vascular growth factor A) stimulation, we discovered that are widespread and preferentially marked genes responsive to VEGFA. have more permissive chromatin environment comparing other BDs. initial...
Coeloglossum viride var. bracteatum is an advanced tonic in Tibetan medicine with anti-inflammatory and neuroprotective effects. Therefore, its anti-AD effects potential targets should be explored. Firstly, a network pharmacological analysis of bioactive molecules their related to AD was performed, the energy metabolism modulating extract (CE) were investigated LPS-induced astrocytes BV2 cellular models. Then, inflammatory factors levels, ATP content real-time measured by RT-qPCR Seahorse...
Abstract Background With the continuous advances in third-generation sequencing technology and increasing affordability of next-generation technology, data from different platforms is becoming more common. While numerous benchmarking studies have been conducted to compare variant-calling performance across approaches, little attention has paid potential leveraging strengths optimize overall performance, especially integrating Oxford Nanopore Illumina data. Results We investigated impact...
With the continuous advances in third-generation sequencing technology and increasing affordability of next-generation technology, data from different platforms is becoming more common. While numerous benchmarking studies have been conducted to compare variant-calling performance across approaches, little attention has paid potential leveraging strengths optimize overall performance, especially integrating Oxford Nanopore Illumina data.
Summary Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best known tumor suppressors that promote homology recombination (HR) arrest cell cycle at G2/M checkpoint. As E3 ubiquitin ligases, their ubiquitinase activity has been involve in HR suppression, but mechanism remains ambiguous. Here, we demonstrated upon genotoxic stress, BRCA1 together with BARD1 catalyzed K48 ployubiquitination on LARP7, a 7SK RNA binding protein control RNAPII pausing,...