A5068411571- Plant-based Medicinal Research
- Research in Cotton Cultivation
- Traditional Chinese Medicine Analysis
- Folklore, Mythology, and Literature Studies
- Poetry Analysis and Criticism
- Ginseng Biological Effects and Applications
- Ecocriticism and Environmental Literature
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Irish and British Studies
- Analytical Chemistry and Chromatography
- Media, Gender, and Advertising
- Themes in Literature Analysis
- Pharmacological Effects of Natural Compounds
- American Literature and Culture
- Computational Drug Discovery Methods
- Alkaloids: synthesis and pharmacology
- Signaling Pathways in Disease
- Animal Disease Management and Epidemiology
- Studies on Chitinases and Chitosanases
- Microtubule and mitosis dynamics
- Retinopathy of Prematurity Studies
Shandong University of Traditional Chinese Medicine
2012-2025
Wuhan University
2023
Chifeng Municipal Hospital
2023
Chinese Academy of Agricultural Sciences
2021
Biotechnology Research Institute
2021
Nanjing Agricultural University
2021
Shanghai Jiao Tong University
2017-2019
Yancheng Third People's Hospital
2019
XinHua Hospital
2019
Henan Agricultural University
2019
In recent years, 3D laser scanning technology has been applied to tunnel engineering. Although more intelligent than traditional measurement technology, it is still challenging estimate the real-time deformation of NATM excavation from detection and ranging point clouds. To further improve accuracy in construction process, this paper proposes an improved Kriging filtering algorithm. Considering spatial correlation described object, optimization method cloud grid studied. By analyzing...
The mitotic spindle checkpoint (SAC) genes have been considered targets of anticancer therapies. Here, we sought to identify the attractive appropriate for human hepatocellular carcinoma (HCC) Through expression profile analysis 137 selected in publicly available microarray datasets, showed that 13 were dramatically up-regulated HCC tissues compared normal livers and adjacent non-tumor tissues. A role proliferation was evaluated by knocking them down via small interfering RNA (siRNA) cells....
Cytoskeleton, as a ubiquitous structure in the cells, plays an important role process of virus entry, replication, and survival. However, action mechanism cytoskeleton invasion Pestivirus into host cells remains unclear. In this study, we systematically dissected key roles main components, microfilaments microtubules endocytosis porcine Pestivirus, Classical swine fever (CSFV). We observed dynamic changes actin filaments CSFV entry. Confocal microscopy showed that induced dissolution...
Rheumatoid arthritis (RA) is now widely recognized as a chronic systemic inflammatory autoimmune disease characterized by swelling, pain and stiffness, which are often disabling. Although the number of drugs available for treatment RA has increased in recent years, they generally expensive, leave patients prone to relapse can result severe effects when discontinued. Thus, there need an inexpensive drug with fewer side that be adhered relieve slow down progression disease. Strychnine,...
Abstract Polycomb repressive complex 2 (PRC2), a H3K27me3 methyltransferase complex, promotes the development of many organs by silencing ectopic transcription program. However, currently little is known about role PRC2 in blood and vascular development. In this study, we interrogated function embryonic ectoderm (EED), core component, both endothelial hematopoietic tissues inactivating floxed murine EED allele with Tie2Cre, which catalyzes recombination lineages. Murine fl/fl ;Tie2Cre (EED...
Cell behaviors are dictated by epigenetic and transcriptional programs. Little is known about how extracellular stimuli modulate these programs to reshape gene expression control cell behavioral responses. Here, we interrogated the response of endothelial cells VEGFA treatment found rapid chromatin changes that mediate broad transcriptomic alterations. VEGFA-responsive genes were associated with active promoters, but in promoter histone marks not tightly linked changes. altered transcription...
Rheumatoid Arthritis (RA) is a chronic autoimmune disease that can lead to joint pain and disability, seriously impact patients' quality of life. Strychni Semen combined with Atractylodes Macrocephala koidz (SA) have pronounced curative effect on RA, there no poisoning (SS). However, its pharmacological mechanisms are still unclear.
Endotoxin-induced acute kidney injury (AKI) is commonly observed in clinical practice. Renal tubular epithelial cell (RTEC) pyroptosis one of the main factors leading to development endotoxin-induced AKI. Mitochondrial dysfunction can lead pyroptosis. However, biological pathways involved potential lipopolysaccharide (LPS)-induced RTECs, notably those associated with mitochondrial dysfunction, are poorly understood. Previous studies have demonstrated that heme oxygenase (HO)-1 confers...
Abstract Mitochondrial reactive oxygen species (ROS) cause Ca2+ release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role hypoxic vasoconstriction (HPV). Here we tested a novel hypothesis that hypoxia-induced RyR-mediated may, turn, promote mitochondrial ROS generation contributing to cellular responses PASMCs. Our data reveal application of caffeine elevate intracellular concentration ([Ca2+]i) by...
The study was designed to investigate the mechanism of Hongjingtian injection (HJT) in treating tubulointerstitial fibrosis (TIF) chronic kidney diseases (CKD) based on network pharmacology and experimental verification.First, active ingredients HJT obtained from literature were screened using Traditional Chinese Medicine Systems Pharmacology (TCMSP) database putative targets predicted Chemmapper, SEA Swiss Target Prediction database. Subsequently, "compound-target" for established. In...
To investigate the intervention effect and mechanism of Aconite Angelica sinensis on myocardial ischemia rats with Yang deficiency blood stasis.SPF-class SD were randomly divided into low-dose high-dose groups. Each group was control group, model drug-administered (FZ, DG, FG; 1 : 0.5, 1, 2). A rat prepared by intraperitoneal injection hydrocortisone isoproterenol plus cold stimulation. given corresponding decoction or distilled water for 14 days. The behavioral changes in each observed....
In the present work we undertook complete mitochondrial genome sequencing of an important retinopathy model inbred C57BL/6 strain for first time. Its mitogenome was 16,312 bp and coding 13 protein-coding genes, 2 ribosomal RNA 22 transfer genes. A total 96 SNPs were examined when compared to reference BN sequence.