A5102026519- Animal Virus Infections Studies
- Legume Nitrogen Fixing Symbiosis
- Cardiac Fibrosis and Remodeling
- Birth, Development, and Health
- Agronomic Practices and Intercropping Systems
- Diet and metabolism studies
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Adipose Tissue and Metabolism
- Microbial Community Ecology and Physiology
- Nematode management and characterization studies
- Gut microbiota and health
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Plant nutrient uptake and metabolism
- Connective tissue disorders research
- Single-cell and spatial transcriptomics
- Zebrafish Biomedical Research Applications
- Genomics and Phylogenetic Studies
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Per- and polyfluoroalkyl substances research
- Prenatal Screening and Diagnostics
- Tuberculosis Research and Epidemiology
- Circular RNAs in diseases
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2023-2025
Jilin University
2017-2025
Shenzhen University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Shanghai Innovative Research Center of Traditional Chinese Medicine
2023
Shaoxing University
2023
Huazhong Agricultural University
2019-2022
Hangzhou Normal University
2022
Fujian Agriculture and Forestry University
2018
Hypertrophic cardiomyopathy (HCM) is a monogenic cardiac disorder commonly induced by sarcomere gene mutations. However, the mechanism for HCM not well defined. Here, we generated transgenic MYH7 R453C and MYH6 piglets found both developed typical hypertrophy. Unexpectedly, serious fibrosis cardiomyocyte loss in ventricular of R453C, piglets, similar to patients. Then, RNA-seq analysis western blotting identified activation ERK1/2 PI3K-Akt pathways R453C. Moreover, observed an increased...
Hazardous impacts caused by harmful algal blooms (HABs) have facilitated the development of novel effective approaches for controlling frequent HABs. Recently, bacteria with algicidal effects, as a promising alternative tool eliminating HABs-forming species received wide concerns. In present study, marine bacterial strain 6A1 potent activity was successfully isolated from bloom Akashiwo sanguinea , and characteristics related to its action were systematically investigated. Sequencing results...
Multiple myeloma (MM) relapse still occurs after a durable response to anti-BCMA chimeric antigen receptor-engineered T (CAR-T) cell therapy with less-defined factors. Herein, we investigated CAR-T-exposed MM patient who relapsed 12 months of remission by single-cell transcriptome sequencing. The bone marrow CAR-T population at exhibited exhaustion and proliferation attenuation. recurrent cells were deficient in or weakly expressed TNFRSF17 (BCMA) but possessed an identical immunoglobulin...
Polyploidy in Gossypium hirsutum conferred different properties from its diploid ancestors under the regulation of transcription factors. The NAC factor is a plant-specific family that can be related to plant growth and development. So far, little known about cotton. This study identified 495 genes three cotton species investigated evolution expansion genome-derived We revealed 15 distinct subfamilies Different had gene proportions, rate, loss orthologous exchange rate. Paleohexaploidization...
Key to the success of legumes is ability form and maintain optimal symbiotic nodules that enable them balance trade-off between symbiosis plant growth. Cytokinin essential for homeostatic regulation nodulation, but mechanism remains incompletely understood. Here, we show a B-type response regulator GmRR11d mediates systemic inhibition nodulation. induced by rhizobia low level cytokinin, can suppress transcriptional activity GmNSP1 on GmNIN1a inhibit soybean positively regulates cytokinin its...
Abstract Polycomb repressive complex 2 (PRC2), a H3K27me3 methyltransferase complex, promotes the development of many organs by silencing ectopic transcription program. However, currently little is known about role PRC2 in blood and vascular development. In this study, we interrogated function embryonic ectoderm (EED), core component, both endothelial hematopoietic tissues inactivating floxed murine EED allele with Tie2Cre, which catalyzes recombination lineages. Murine fl/fl ;Tie2Cre (EED...
Hemophilia B is an X-linked recessive bleeding disorder caused by abnormalities in the coagulation factor IX gene. Without prophylactic treatment, patients experience frequent spontaneous episodes. Well-characterized animal models are valuable for determining pathobiology of disease and testing novel therapeutic innovations. Here, we generated a porcine model hemophilia using combination CRISPR/Cas9 somatic cell nuclear transfer. Moreover, tested possibility therapy gene insertion. Frequent...
Resveratrol is a naturally occurring polyphenolic compound with known cardioprotective, anti-inflammatory, and antioxidant properties. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) associated the risk of cardiovascular disease. Here, we investigated effects resveratrol on Lp-PLA2 expression in vitro vivo explored underlying mechanisms.Human monocytic cells (THP-1) were induced to differentiate into macrophages for an experimental model. suppressed reduced inflammation;...
Cardiac fibrosis is an integral aspect of every form cardiovascular diseases, which one the leading causes death worldwide. It urgent to explore new effective drugs and treatments. In this paper, transverse aortic constriction (TAC)-induced cardiac was significantly alleviated by a cocktail antibiotics clear intestinal flora, indicating that gut microbiota associated with disease process fibrosis. We transplanted feces from sham-operated TAC-treated mice treated antibiotics. found dysbiosis...
Elevated plasma Lp-PLA2 (lipoprotein-associated phospholipase A2) activity is closely associated with an increased risk of cardiovascular events. However, whether and how directly involved in the pathogenesis atherosclerosis still unclear. To examine hypothesis that could be a potential preventative target atherosclerosis, we generated knockout rabbits investigated pathophysiological functions Lp-PLA2.Lp-PLA2 were using CRISPR/Cas9 system to assess role lipids regulation identify its...
Abstract Single-cell sequencing is useful for illustrating the cellular heterogeneities inherent in many intricate biological systems, particularly human cancer. However, owing to difficulties acquiring, amplifying and analyzing single-cell genetic material, obstacles remain diversity assessments such as single nucleotide polymorphism (SNP) analyses, rendering interpretations of omics data elusive. We used RNA-Seq from bulk colon cancer samples analyze SNP profiles both structural functional...
Classical swine fever (CSF) caused by the classical virus (CSFV) has resulted in severe losses to pig industry worldwide. It been proposed that lipid synthesis is essential for viral replication, and lipids are involved protein maturation envelope production. However, specific crosstalk between CSFV host cell metabolism still unknown. In this study, we found infection increased intracellular cholesterol levels PK-15 cells. Further analysis demonstrated upregulated PCSK9 expression block...
Aims Making a correct and rapid diagnosis is essential for managing pulmonary tuberculosis (PTB), particularly multidrug-resistant tuberculosis. We aimed to evaluate the efficacy of combination simultaneous amplification testing (SAT) reverse dot blot (RDB) detection Mycobacterium (MTB) drug-resistant mutants in respiratory samples. Methods 225 suspected PTB 32 non-TB disease samples were collected. All sputum sent acid-fast bacilli smear, SAT, culture drug susceptibility (DST) by BACTEC TM...
An emerging topic in virology is that viral replication closely linked with the metabolic reprogramming of host cells. Understanding effects cell metabolism due to classical swine fever virus (CSFV) infection and underling mechanisms would facilitate controlling spread (CSF). In current study, we found CSFV enhanced aerobic glycolysis PK-15 Blocking 2-deoxy-d-glycose or disrupting enzymes PFKL LDHA decreased replication. Lactate was identified as an important molecule replication,...