A5102004079- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Animal Genetics and Reproduction
- Pediatric health and respiratory diseases
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- interferon and immune responses
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Microbial Metabolic Engineering and Bioproduction
- IL-33, ST2, and ILC Pathways
- Bioenergy crop production and management
- Protease and Inhibitor Mechanisms
- Connective Tissue Growth Factor Research
- Nitrogen and Sulfur Effects on Brassica
Affiliated Hospital of Hebei University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Guizhou Provincial People's Hospital
2017-2023
Sichuan Agricultural University
2021-2023
Shanghai Ocean University
2023
Southwest University
2021
Hybrid Rapeseed Research Center of Shaanxi Province
2021
Jilin University
2018-2020
Hefei Institutes of Physical Science
2017
Objective This study aimed to investigate the clinical features of neuronal antibodies related autoimmune cerebellar ataxia (ACA) and provide guidance for diagnosis treatment this disease. Methods Demographic data were collected from antibody-positive patients with ACA who admitted Department Neurology, Affiliated Hospital Hebei University, January 2018 February 2023. A retrospective analysis on manifestations, laboratory examinations, imaging data, treatment, prognosis was performed....
The fat-1 gene from Caenorhabditis elegans encodes a fatty acid desaturase which was widely studied due to its beneficial function of converting n-6 polyunsaturated acids (n-6PUFAs) n-3 (n-3PUFAs). To date, many transgenic animals have been generated study disease pathogenesis or improve meat quality. However, all them were using random integration method with variable transgene expression levels and the introduction selectable marker genes often raise biosafety concern. this end, we aimed...
Hemophilia B is an X-linked recessive bleeding disorder caused by abnormalities in the coagulation factor IX gene. Without prophylactic treatment, patients experience frequent spontaneous episodes. Well-characterized animal models are valuable for determining pathobiology of disease and testing novel therapeutic innovations. Here, we generated a porcine model hemophilia using combination CRISPR/Cas9 somatic cell nuclear transfer. Moreover, tested possibility therapy gene insertion. Frequent...
Chinese tallow (Sapium sebiferum L.) is a promising landscape and bioenergy plant. Measuring gene expression by quantitative real-time polymerase chain reaction (qRT-PCR) can provide valuable information on function. Stably expressed reference genes for normalization are prerequisite ensuring the accuracy of target level among different samples. However, in have not been systematically validated. In this study, 12 candidate (18S, GAPDH, UBQ, RPS15, SAND, TIP41, 60S, ACT7, PDF2, APT, TBP,...
Amyloidogenesis is one of the key pathophysiological changes in Alzheimer's disease (AD). Accumulation toxic Aβ results from catalytic processing β-amyloid precursor protein (APP) associated converting enzyme 1 (BACE1) activity. It reported that dead-box helicase 17 (DDX17) controls RNA metabolism and involved development multiple diseases. However, whether DDX17 might play a role amyloidogenesis has not been documented. In present study, we found level was significantly increased HEK...
Abstract The present study aimed to investigate the effects of lncRNA FENDRR on migration and invasion malignant melanoma (MM) cells. expression levels in MM tissues cell lines were detected using qRT-PCR, followed by construction FENDRR-knocked down overexpressed stable Then proliferation, MTT assay Transwell assay. protein matrix metallopeptidase 2 (MMP2), MMP9, related factors JNK/c-Jun pathway Western blot. was down-regulated lines. Besides, its different cells diverse. Knockdown...
Triticum boeoticum Boiss (AbAb, 2n = 2x 14) is one of the sources blue grain trait controlled by aleurone layer 2 (Ba2). However, underlying genes have not been cloned. In this study, a transcriptomic comparison between blue-grained wheat-T. substitution line and its wheat parent identified 41 unigenes related to anthocyanin biosynthesis 29 transport. The bHLH transcription factor gene TbMYC4A showed higher expression level in line. contained three characteristic domains (bHLH-MYC_N, HLH...
Abstract Background Weeds are not only economically important but also fascinating models for studying the adaptation of species in human-mediated environments. Aegilops tauschii is D-genome donor common wheat a weed that influences production. How shading stress caused by adjacent plants affects Ae. growth fundamental scientific question agriculture, such as control and breeding. Result The present study indicated shade avoidance strategy response to stress. exhibited increases specific...
<p indent=0mm>The petal color has been one of the major goals breeding and genetic research in <italic>Brassica napus</italic> L. To date, there have no reports about interval location dominant orange gene trait <italic>B</italic>.<italic> In this study, we constructed an F<sub>2</sub> mapping population with 458 individuals from cross between DH Y05 (yellow petal) R08 (orange petal). Whole-genome re-sequencing DNAs transcriptome sequencing RNAs were two populations each composed 30 showing...
Background Retinal pigment epithelium (RPE) cell transplantation is the primary means of human trial for treatment retinal degeneration.Induced pluripotent stem cells (iPSCs) will become an important source transplantation.In addition, iPS-RPE may provide a personalized platform patient's own treatment. Objective This study was to evaluate feasibility fibroblasts differentiate toward iPSCs from retinitis pigmentosa (RP) patients and iPSC-RPE non-RP individual by retroviral...
The reference gene expression is not always stable under different experimental conditions, and screening of suitable genes a prerequisite in quantitative real-time polymerase chain reaction (qRT-PCR). In this study, we investigated selection, the most for Chinese mitten crab (Eriocheir sinensis) was screened stimulation Vibrio anguillarum copper ions, respectively. Ten candidate were selected, including arginine kinase (AK), ubiquitin-conjugating enzyme E2b (UBE), glutathione S-transferase...
Following the publication of this paper, it was drawn to Editor's attention by a concerned reader that colony formation data shown in Fig. 2C on p. 333 had already appeared previously published articles written different authors at research institutes. Owing fact contentious above article been prior its submission Oncology Reports, Editor has decided paper should be retracted from Journal. The were asked for an explanation account these concerns, but Editorial Office did not receive reply....