A5080823195- Wound Healing and Treatments
- Mesenchymal stem cell research
- Pain Mechanisms and Treatments
- Immune cells in cancer
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Dermatologic Treatments and Research
- Nanoplatforms for cancer theranostics
- Diabetic Foot Ulcer Assessment and Management
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Nerve injury and regeneration
- Surgical Sutures and Adhesives
- Ion channel regulation and function
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Body Contouring and Surgery
- Skin and Cellular Biology Research
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Spine and Intervertebral Disc Pathology
- Cancer Cells and Metastasis
- Water Quality and Pollution Assessment
Shanghai Jiao Tong University
2024-2025
Shanghai First People's Hospital
2024-2025
Pennsylvania State University
2016-2025
Helmholtz Zentrum München
2017-2024
Zhengzhou University
2023
German Center for Lung Research
2022
Taizhou People's Hospital
2016-2022
Nantong University
2016-2022
Huaiyin Institute of Technology
2021
Universität Ulm
2011-2020
Proper activation of macrophages (Mφ) in the inflammatory phase acute wound healing is essential for physiological tissue repair. However, there a strong indication that robust Mφ responses may be causal fibrotic response always accompanying adult healing. Using complementary approach vitro and vivo studies, we here addressed question whether mesenchymal stem cells (MSCs)-due to their anti-inflammatory properties-would control fibrosis murine model full-thickness skin wounds. We have shown...
Abstract Extravasation of monocytes into tissue and to the site injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) proteins. Protein arginine methyltransferase 7 (PRMT7) an epigenetic factor that has capacity mono-methylate histones on residues. Here we show in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression elevated lung localized macrophages. In mouse models COPD, fibrosis skin injury, reduced...
Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration. Though of prime interest, their potentially protective role on neutrophil-induced damage, associated with high morbidity mortality, has not been explored in sufficient detail. Here we report the therapeutic skill MSCs to suppress unrestrained neutrophil activation attenuate severe damage a murine immune-complex mediated vasculitis model unbalanced activation. MSC-mediated suppression was due intercellular...
High macrophage infiltration into tumours often correlates with poor prognoses; in colorectal, stomach and skin cancers, however, the opposite is observed but mechanisms behind this phenomenon remain unclear. Here, we sought to understand how tumour-associated macrophages (TAMs) colorectal cancer execute tumour-suppressive roles. We found that TAMs a model were pro-inflammatory inhibited proliferation of tumour cells. also produced chemokines attract T cells, stimulated allogeneic cells...
Abstract Scars are more severe when the subcutaneous fascia beneath dermis is injured upon surgical or traumatic wounding. Here, we present a detailed analysis of cell mobilisation by using deep tissue intravital live imaging acute wounds, fibroblast lineage-specific transgenic mice, and skin-fascia explants (scar-like in dish – SCAD). We observe that injury triggers swarming-like collective migration fibroblasts progressively contracts skin form scars. Swarming exclusive to fibroblasts,...
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of inflammation, contraction scar formation1. Here we identify a multipotent fibroblast progenitor marked CD201 expression in the fascia, deepest connective layer skin. Using skin injury models mice, single-cell transcriptomics genetic lineage tracing, ablation gene deletion models, demonstrate that CD201+ progenitors control pace wound healing generating multiple specialized cell types, from...
The N6-methyladenosine (m 6 A) modification of RNA is an emerging epigenetic regulatory mechanism that has been shown to participate in various pathophysiological processes. However, its involvement modulating neuropathic pain still poorly understood. In this study, we elucidate a functional role the m A demethylase alkylation repair homolog 5 (ALKBH5) trigeminal-mediated pain. Peripheral nerve injury selectively upregulated expression level ALKBH5 injured trigeminal ganglion (TG) rats....
Endostatin (ES) is a c-terminal proteolytic fragment of collagen XVIII with promising antitumour properties in several tumour models, including human glioblastoma. We hypothesized that this peptide could interact plasma membrane ion channels and modulate their functions.Using cell proliferation migration assays, patch clamp Western blot analysis, we studied the effects ES on glioblastoma U87 cells, mediated by T-type Ca²⁺ channels.Extracellular application reversibly inhibited channel...
In this study, we report the beneficial effects of a newly identified dermal cell subpopulation expressing ATP-binding cassette subfamily B member 5 (ABCB5) for therapy nonhealing wounds. Local administration ABCB5
We here address the question whether unique capacity of mesenchymal stem cells to re-establish tissue homeostasis depends on their potential sense pathogen-associated molecular pattern and, in consequence, mount an adaptive response interest repair. After injection MSCs primed with bacterial wall component LPS into murine wounds, unexpected acceleration healing occurs, clearly exceeding that non-primed MSCs. This correlates a fundamental reprogramming transcriptome LPS-treated as deduced...