A5021334030- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Myofascial pain diagnosis and treatment
- Mesenchymal stem cell research
- Pain Management and Treatment
- Body Contouring and Surgery
- Neonatal Respiratory Health Research
- Antimicrobial Peptides and Activities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatologic Treatments and Research
- Asian Culture and Media Studies
- Cystic Fibrosis Research Advances
- Vitamin D Research Studies
- Surgical Sutures and Adhesives
- Inflammasome and immune disorders
- Thermoregulation and physiological responses
- Inhalation and Respiratory Drug Delivery
- Tendon Structure and Treatment
- Chronic Disease Management Strategies
- Air Quality and Health Impacts
- Ion Channels and Receptors
- Respiratory viral infections research
- Burn Injury Management and Outcomes
- Essential Oils and Antimicrobial Activity
- Neonatal and Maternal Infections
Helmholtz Zentrum München
2022-2025
Tongji University
2018-2025
Shanghai Pulmonary Hospital
2017-2025
German Center for Lung Research
2025
Chengdu University of Technology
2022
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of inflammation, contraction scar formation1. Here we identify a multipotent fibroblast progenitor marked CD201 expression in the fascia, deepest connective layer skin. Using skin injury models mice, single-cell transcriptomics genetic lineage tracing, ablation gene deletion models, demonstrate that CD201+ progenitors control pace wound healing generating multiple specialized cell types, from...
The incidence of Aspergillus fumigatus infection and the rate resistance to antifungal drugs have sharply increased in recent years. LL37 has been reported as a host defense peptide with broad-spectrum antibacterial activities. However, role during A. remains unclear. Here, we examined interaction between found that synthetic could directly bind surface fumigatus, disrupting integrity cell wall vitro. inhibited mycelial growth concentration-dependent manner, rather than fungicidal effect...
Abstract The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion adipocytes into myofibroblasts. Here, we directly explore the potential plasticity fibroblasts after skin injury. Using genetic lineage tracing live imaging in explants wounded animals, observe that injury induces a transient migratory state with vastly distinct cell migration patterns behaviours from fibroblasts. Furthermore, adipocytes, do not contribute formation remain...
Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in community acquired pneumonia (CAP) patients. We aimed to investigate characteristics and mortality risk factors COPD patients hospitalized with CAP.A retrospective cohort study was conducted at Shanghai Pulmonary Hospital Dahua Hospital. Clinical demographic data diagnosed CAP were collected between January 2015 June 2016. Logistic regression analysis performed screen CAP.Of total 520 patients, 230...
PM2.5, a major component of air pollutants, has caused severe health problems. It been reported that PM2.5 index is closely associated with severity influenza A virus (IAV) infection. However, the underlying mechanisms have not addressed. NLRP3 inflammasome and type I interferon signaling regulate host defense against The present study investigated potential effects pollutants on infection in vitro vivo. In this study, different concentrations were pre-exposed to macrophages mice before IAV...
Abstract Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung and observe disassembly transfer of macromolecules from pleuro-alveolar junctions (PAJs) into deep tissue, to activate fibroblasts fibrosis. Disassembly PAJ occurs by activating cysteine-type proteolysis on pleural mesothelium. The niche the cascade is active in patient biopsies, persists chronic models, wanes down acute...
The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood. This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018. Serum 25-hydroxyvitamin levels were measured with bronchiectasis, clinical data including sputum culture results collected. To investigate the P. colonization, we correlation analysis logistic regression. Additionally, vitro experiments bone marrow-derived...
Pseudomonas aeruginosa (PA) has emerged as a pressing challenge to pulmonary infection and lung damage. The LL37 peptide is an efficient antimicrobial agent against PA strains, but its application limited because of fast clearance in vivo, biosafety concerns, low bioavailability. Thus, albumin-based nanodrug delivery system with reduction sensitivity was developed by forming intermolecular disulfide bonds increase vivo performance PA. Cationic can be efficiently encapsulated via...
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<b>Background and Objectives:</b> We aimed to compare the predictive values of PSI, CURB-65 APACHE-Ⅱ on different clinical outcomes in CAP patients comorbid with COPD. <b>Methods:</b> Clinical demographic data were collected from 2015 2016. ROC curves conducted predict validity severity scoring systems in-hospital mortality, 60-day need for ICU admission NIMV. Logistic regression analysis was performed screen prognosis factors COPD-CAP patients. <b>Main Results:</b> 520 recruited, 230 The...