A5101170602- Mesenchymal stem cell research
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Pharmacological Effects of Natural Compounds
- Myofascial pain diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Histone Deacetylase Inhibitors Research
- Breast Implant and Reconstruction
- Body Contouring and Surgery
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- Pain Management and Treatment
- Skin Protection and Aging
- Synthesis and Characterization of Heterocyclic Compounds
- Spinal Cord Injury Research
- bioluminescence and chemiluminescence research
- Reconstructive Surgery and Microvascular Techniques
- Pressure Ulcer Prevention and Management
- Chemical Looping and Thermochemical Processes
- Synthesis of Tetrazole Derivatives
- Thermochemical Biomass Conversion Processes
- Phytochemistry and biological activity of medicinal plants
- Developmental Biology and Gene Regulation
- Flavonoids in Medical Research
Helmholtz Zentrum München
2023-2025
German Center for Lung Research
2025
PLA Rocket Force University of Engineering
2025
Nanjing Drum Tower Hospital
2010-2024
Southeast University
2024
Macquarie University
2023
Xiamen University
2023
Hebei University of Chinese Medicine
2015-2020
Stomatology Hospital
2011-2015
Peking University
2011-2015
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of inflammation, contraction scar formation1. Here we identify a multipotent fibroblast progenitor marked CD201 expression in the fascia, deepest connective layer skin. Using skin injury models mice, single-cell transcriptomics genetic lineage tracing, ablation gene deletion models, demonstrate that CD201+ progenitors control pace wound healing generating multiple specialized cell types, from...
Diabetic foot ulcer (DFU) frequently leads to non-traumatic amputation and finally even death. However, the mechanism of DFU is not fully understood. Interleukin 25 (IL-25), an alarmin cytokine that responds tissue injury, has been reported participate in regeneration maintaining glucose homeostasis. role IL-25 diabetic wound healing remains unknown. Here, we showed interleukin 17 receptor B (IL-17RB), functional IL-25, was significantly inhibited skin both patients with streptozotocin...
Aims: Studies show that VEGF can promote tissue regeneration in diabetic wounds. The aim of this study was to evaluate the effects a new composite biomaterial, collagen scaffold with CBD-VEGF, for wound healing rat model. Materials and methods: We produced loaded which allowed bind scaffold. model constructed by injecting streptozocin (STZ) peritoneally removing 2 x 2.5 cm thick slice skin from back animal. Animals were randomly divided into 4 groups: blank control (BC Group, n = 24), PBS...
Abstract The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion adipocytes into myofibroblasts. Here, we directly explore the potential plasticity fibroblasts after skin injury. Using genetic lineage tracing live imaging in explants wounded animals, observe that injury induces a transient migratory state with vastly distinct cell migration patterns behaviours from fibroblasts. Furthermore, adipocytes, do not contribute formation remain...
Malignant melanoma (MM) is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer epidermis associated with poor clinical outcomes. Early-stage MM typically treated through surgical removal, while chemotherapy radiotherapy are common conventional treatment options come harmful side effects. Emerging therapies such as immunotherapy, photodynamic therapy, biologic photothermal therapy present hopeful for due to their effective secure drug delivery...
Abstract Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung and observe disassembly transfer of macromolecules from pleuro-alveolar junctions (PAJs) into deep tissue, to activate fibroblasts fibrosis. Disassembly PAJ occurs by activating cysteine-type proteolysis on pleural mesothelium. The niche the cascade is active in patient biopsies, persists chronic models, wanes down acute...
Aims: To study the effect of Adipose-derived stem cells (ADSCs) on fibrosis hypertrophic scar-derived fibroblasts (HSFs) and its concrete mechanism. Background: ADSCs have been reported to reduce collagen production fibroblast proliferation in co-culture experiments. Conditioned medium from adipose-derived (ADSCs-CM) has successfully inhibited by decreasing expression type І (Col1) α-smooth muscle actin (α-SMA) rabbit ear scar models. Hepatocyte growth factor (HGF), primary ADSCs-CM, shown...
Uranium-containing high-entropy alloys (HEAs) exhibit great potential as a novel energetic structural material, attributed to their excellent performance in impact energy release, superior mechanical properties, and high density. This study investigates the effects of Ta content on phase stability, lattice constant, density, elastic constants, polycrystalline moduli, electronic structure (UNbMoHf)54−xTax (where x = 2, 6, 10, 14, 18), utilizing combination density functional theory (DFT)...
Monoammonium glycyrrhizinate (MAG) is an aglycone of glycyrrhizin that found in licorice and often used clinically as injection to treat liver diseases. However, the effect MAG on cardiac function its possible cellular mechanisms remain unclear. We explored protective effects against myocardial ischemic injury (MII) induced by isoproterenol (ISO), well via molecular biology techniques patch-clamp recording.A rat model ischemia was administering ISO (85 mg/kg) subcutaneously for 2 consecutive...
Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved inflammatory-related response. INK128 is a novel mTOR kinase inhibitor clinical development. However, the exact roles MDSCs healing wound unclear. Mice models normal, diabetic, diabetic+INK128 were constructed. Bone marrow (BM)-derived macrophages RAW264.7 cell line co-cultured with MDSCs, which induced at...
This study aimed at evaluating the effects of collagen scaffold with Bcl-2-modified adipose-derived stem cells (ADSCs) on wound repair in streptozotocin-induced diabetic mice. A round full thickness skin defect a diameter 7 mm was made mice model. The experimental were divided into 4 groups (n = 12 each): group (control group), B (scaffold C (ADSCs-scaffold and D (Bcl-2-ADSCs-scaffold group). On days 3, 7, 10, 14 after surgery, characteristics healing observed, tissues sampled for histology...
Tannic acid presents in varying concentrations plant foods, and relatively high green teas red wines. Human ether-à-go-go-related gene (hERG) channels expressed multiple tissues (e.g. heart, neurons, smooth muscle cancer cells), play important roles modulating cardiac action potential repolarization tumor cell biology. The present study investigated the effects of tannic acid, wines on hERG currents. currents stably transfected HEK293 cells were studied with a perforated patch clamp...
We examined the influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury.Sixty injury were divided into an experimental group and a control given cells or equivalent amount phosphate-buffered saline by intravenous transplantation, respectively.Basso, Beattie, Bresnahan (BBB) motor function assessment was performed at different times after von Willebrand factor (vWF) immunofluorescence Western blot analysis vascular endothelial growth (VEGF) protein also...
Wounds in patients with diabetes mellitus are one of the most prevalent impaired wounds world. Vascular endothelial growth factor (VEGF) is important proangiogenic mediators. Artificial dermal (AD) such as Pelnac® has been shown, humans and animal models, a great therapeutic potential full-thickness skin wounds. We attempt to promote wound healing diabetic porcine models through combined use AD constant concentration VEGF or gradient. created excisional models. Analyzed process images,...