A5102724573- Antibiotic Resistance in Bacteria
- Inflammasome and immune disorders
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Pneumonia and Respiratory Infections
- Bacterial Genetics and Biotechnology
- Bacterial Identification and Susceptibility Testing
- Biosensors and Analytical Detection
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Peptides and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Kawasaki Disease and Coronary Complications
- RNA modifications and cancer
- Escherichia coli research studies
- Infections and bacterial resistance
- Antibiotic Use and Resistance
- IL-33, ST2, and ILC Pathways
- Irrigation Practices and Water Management
- Rice Cultivation and Yield Improvement
- Plant Pathogenic Bacteria Studies
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
Sichuan University
2023-2025
First Affiliated Hospital of Guangzhou Medical University
2014-2025
Guangzhou Medical University
2014-2025
Shanghai Pulmonary Hospital
2019-2025
Texas A&M University
2023-2025
Mitchell Institute
2023-2025
Tongji University
2019-2025
Tianjin Medical University General Hospital
2024-2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Introduction Vascular smooth muscle cells (VSMCs) are the predominant cell type in medial layer of aorta, which plays a critical role aortic diseases. Innate immunity is main driving force for cardiovascular Methods To determine roles innate VSMC and pathologies, we performed transcriptome analyses on aortas from ApoE –/– angiotensin II (Ang II)-induced aneurysm (AAA) time course, atherosclerosis as well VSMCs stimulated with danger-associated molecular patterns (DAMPs). Results We made...
Development of fluoroquinolone resistance can involve several mechanisms that include chromosomal mutations in genes ( gyrAB and parCE ) encoding the target bacterial topoisomerase enzymes, increased expression AcrAB-TolC efflux system, acquisition transmissible quinolone-resistance genes. In this study, 176 Salmonella isolates from animals with a broad range ciprofloxacin MICs were collected to analyze contribution these different phenotypes. All classified according their susceptibility...
Developing an effective treatment strategy of drug delivery to improve diabetic wound healing remains a major challenge in clinical practice nowadays, due multidrug-resistant bacterial infections, angiopathy, and oxidative damage the microenvironment. Herein, convenient was designed through self-healing multiple-dynamic-bond cross-linked hydrogel with interpenetrating networks, which formed by cross-linking reversible catechol-Fe3+ coordinate bonds, hydrogen bonding, Schiff base bonds. The...
Redundant carbapenemase-producing (RCP) bacteria, which carry double or multiple carbapenemases, represent a new and concerning phenomenon. The objective of this study is to conduct comprehensive analysis the epidemiology genetic mechanisms RCP strains support targeted surveillance control measures. A retrospective was conducted using data from 277 articles. Statistical performed determine evaluate species prevalence, proportions antibiotic susceptibility profiles, sample information,...
Salmonella spp. is one of the most important food-borne pathogens causing digestive tract and invasive infections in both humans animals. Extended-spectrum β-lactamases (ESBLs) especially CTX-M-type ESBLs are increasingly being reported worldwide China. These studies seldom focused on isolates from food-producing The aim this study was to characterize antimicrobial resistance profiles, serotypes particular, CTX-M producing chickens pigs were identified by API20E system polymerase chain...
The incidence of Aspergillus fumigatus infection and the rate resistance to antifungal drugs have sharply increased in recent years. LL37 has been reported as a host defense peptide with broad-spectrum antibacterial activities. However, role during A. remains unclear. Here, we examined interaction between found that synthetic could directly bind surface fumigatus, disrupting integrity cell wall vitro. inhibited mycelial growth concentration-dependent manner, rather than fungicidal effect...
Abstract The aim of this study was to elucidate the epidemiology third generation cephalosporin resistant Samonella isolates from pork a slaughterhouse in China and features transferable elements carrying bla CTX-M genes. One hundred twenty-six (7.3%) Salmonella were identified; S . Derby Rissen most two prevalent serotypes. Among these 20 (15.8%) cephalosporins nine them carried CTX-M-27 S1-PFGE replicon typing -carrying plasmids showed that seven untypeable about 104 Kb IncP 300 Kb....
As the prevalence of Staphylococcus aureus infections is worldwide concern, phenotype and genotype in prevalent MRSA strains require longitudinal investigation. In this study, antibiotic resistance, virulence gene acquisition, molecular type were determined on a large scale nosocomial S. Southern China during 2009-2015. Bacterial identification antimicrobial susceptibility to 10 antibiotics tested by Vitek-2. Virulence genes encoding staphylococcal enterotoxins (SEA, SEB, SEC, SED, SEE),...
Introduction Klebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, mechanisms underlying K. -induced sepsis its pathogenesis remain unclear. Acute respiratory failure leading cause of mortality systemic infections, highlighting need to better understand host immune response bacterial clearance mechanisms. Method To investigate impact infection on organ function response, we...
With the increasing entrepreneurial activities of college students, building an effective project recommendation system is crucial to stimulate innovation and improve success rate entrepreneurship. Traditional collaborative filtering methods have achieved some in recommender systems. However, with increase data scale complexity projects, effect traditional gradually limited. This study uses a set containing large number compares model based on deep learning methods. Experimental results show...
Klebsiella michiganensis, an emerging opportunistic pathogen, poses public health risks due to its increasing multidrug resistance (MDR), especially carbapenems. A 46-year-old man with pulmonary fibrosis was hospitalized in Guangzhou, China, for worsening pneumonia. multidrug-resistant K. michiganensis strain (YK6) isolated from his sputum before treatment. The characterized using MALDI-TOF mass spectrometry, antimicrobial susceptibility testing (AST), and whole genome sequencing (WGS)....
Carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) is a major public health threat worldwide. CRKP-BSI associated with poor outcomes, elevated morbidity and mortality, high healthcare costs. Therefore, the identification of risk factors for mortality are critical preventing controlling CRKP in hospitals. This retrospective case-case-control study was conducted at General Hospital Tianjin Medical University, tertiary teaching hospital, from 2017 to 2023. It included...
Background Detection of Acinetobacter baumannii has been relying primarily on bacterial culture that often fails to return useful results in time. Although DNA-based assays are more sensitive than detecting the pathogen, molecular inconsistent and challenged by doubts false positives, such as those due system- environment-derived contaminations. In addition, these tools require expensive laboratory instruments. Therefore, establishing for field use simpler platforms. The loop-mediated...