A5101756580- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Luminescence Properties of Advanced Materials
- Perovskite Materials and Applications
- Sensorless Control of Electric Motors
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Control Systems in Engineering
- GABA and Rice Research
- Infections and bacterial resistance
- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Immune Response and Inflammation
- Ovarian function and disorders
- Pneumonia and Respiratory Infections
- Advanced Algorithms and Applications
- Machine Learning in Bioinformatics
- Graphene and Nanomaterials Applications
- Cardiac Imaging and Diagnostics
- Renal Diseases and Glomerulopathies
- Pesticide and Herbicide Environmental Studies
- Traditional Chinese Medicine Analysis
- Nanoparticles: synthesis and applications
First Affiliated Hospital of Zhengzhou University
2015-2025
Beijing University of Chinese Medicine
2017-2024
First Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
South China Agricultural University
2023
Ministry of Agriculture and Rural Affairs
2023
First Affiliated Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Zhengzhou University
2022-2023
Second Hospital of Shandong University
2015
Abstract Lanthanide ions, as dopants, have evoked widespread research interest owing to the rich optical, magnetic, and electrical properties, but their luminescent intensity is always limited by typical concentration quenching. Herein, a holmium‐based double perovskite of Cs 2 NaHoCl 6 reported, which surprisingly breaks through this barrier achieves efficient red‐NIR emission virtue large unit cell, low phonon energy, high content activators, cross relaxation phenomenon between Ho 3+ . The...
Diabetic nephropathy (DN) represents a significant microvascular complication in diabetes, entailing intricate molecular pathways and mechanisms associated with cardiorenal vascular diseases. Prolonged hyperglycemia induces renal endothelial dysfunction damage via metabolic abnormalities, inflammation, oxidative stress, thereby compromising hemodynamics. Concurrently, fibrotic sclerotic alterations exacerbate glomerular tubular injuries. At macro level, reciprocal communication between the...
Azvudine and nirmatrelvir-ritonavir (Paxlovid) were widely used to treat patients with COVID-19 in China during the Omicron wave. However, efficacy safety of azvudine versus Paxlovid are poorly established. This study included 40,876 hospitalized from eleven hospitals Henan Xinjiang Provinces, China. Clinical outcomes compared between two drugs via Kaplan-Meier analysis Cox regression models. Additionally, vitro vivo experiments evaluate antitumor effects both drugs. Single-cell RNA...
Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation ferroptosis is closely associated with HCC. However, effect epigenetic mRNA m5C modification on HCC remains unclear. Methods In this study, was evaluated by detecting lipid reactive oxygen species (lipid ROS), ferrous ion and 4‐hydroxynonenal (4‐HNE) xenograft mouse model, diethylnitrosamine (DEN)‐initiated model so forth. The regulatory mechanisms YBX1...
Abstract NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), posttranscriptional modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function pancreatic cancer (PC) needs to be elucidated. Herein, we determined that was overexpressed PC tissues and related aggressive clinical features. Silence by lentivirus weakened capability proliferation, migration invasion cells vitro inhibited growth...
Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves wide range content, along with high requirements for doctor's professionalism multi-specialty teamwork, as well great demand time-sensitive treatments. However, this not matched care professionals current state medical in China. Telemedicine, which shortens distance gap disease diagnosis treatments regions through...
Background: Ubiquitin-proteasome system (UPS) is implicated in cancer occurrence and progression. Targeting UPS emerging as a promising therapeutic target for treatment. Nevertheless, the clinical significance of hepatocellular carcinoma (HCC) has not been entirely elucidated. Methods: Differentially expressed genes (DEUPS) were screened from LIHC-TCGA datasets. The least absolute shrinkage selection operator (LASSO) stepwise multivariate regression analysis conducted to establish UPS-based...
The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility its application in treating liver cancer Junsheng Gu, Ranran Sun, Shen Shen, Zujiang Yu Department Infectious Diseases, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic China Objective: This study was designed to explore Toll-like receptor 4 (TLR4) (LPS) cell perform adjuvant therapy. Methods: Human lines HepG2, H7402, PLC/PRF/5 were taken as models,...
Cancer cells differ from normal body in their ability to divide indefinitely and evade programmed cell death. Crosstalk between apoptosis cycle processes promotes balance proliferation death, limits population growth survival of cells. However, intricate relationships them how they are able manipulate the fate cancer still remain be clarified. Identification key factors involved both regulation may help address this problem.Identification such proteins was carried out, using a series...
<title>Abstract</title> 5- methylcytosine (m5C) is a prevalent posttranscriptional RNA modification which participates in the initiation and progression of various cancers. NSUN2 main methyltransferase import for catalyzing m5C formation. However, its regulatory role potential mechanism osteosarcoma remain unclear. Here, we demonstrated that expression was markedly upregulated tissues cell lines. Clinically, increased associated with poor prognosis. Functional studies revealed significantly...
To observe the basic metabolic characteristics of obese patients with polycystic ovarian syndrome (PCOS), and compare effect laparoscopic sleeve gastrectomy metformin treatment after 3 months.
Adv. Sci. 2020, 7, 1902996 In the originally published version of this article, 18F-FDG uptake and PET-CT analysis LF patient after TMZ treatment in Figure 4A inadvertently features normal control. The correct is shown below. authors declare that correction does not affect description, interpretation, or original conclusions manuscript. regret inconvenience error may have caused.
To establish a quantitative model for the online analysis of hesperidin content in extraction process Huatan Qushi decoction individuals with phlegm-dampness constitution by using near-infrared (NIR) spectroscopy and partial least squares (PLS) methods.The reference hesperidin, an effective ingredient decoction, was determined high-performance liquid chromatography (HPLC). The modeling band selected synergy interval PLS (SiPLS) algorithms, demonstrating relationship between NIR predictive...